{"id":11004,"date":"2025-01-18T12:05:00","date_gmt":"2025-01-18T11:05:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11004"},"modified":"2025-08-07T12:10:38","modified_gmt":"2025-08-07T10:10:38","slug":"successful-treatment-of-refractory-ulcerative-colitis-with-5-aminosalicylic-acid-intolerance-and-biologic-therapy-resistance-using-combined-granulocyte-and-monocyte-adsorptive-apheresis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/successful-treatment-of-refractory-ulcerative-colitis-with-5-aminosalicylic-acid-intolerance-and-biologic-therapy-resistance-using-combined-granulocyte-and-monocyte-adsorptive-apheresis\/","title":{"rendered":"Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Tanaka+T&amp;cauthor_id=39834662\">Tomotaka Tanaka<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834662\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Hirano+D&amp;cauthor_id=39834662\">Daiki Hirano<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834662\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ishimaru+S&amp;cauthor_id=39834662\">Syohei Ishimaru<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834662\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Arataki+K&amp;cauthor_id=39834662\">Keiko Arataki<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834662\/#full-view-affiliation-1\">1<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Cureus 2025 Jan 18;17(1):e77641.\u00a0doi: 10.7759\/cureus.77641.\u00a0eCollection 2025 Jan.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><span style=\"color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif; font-size: 16px; white-space-collapse: collapse;\">We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. Although induction of remission was achieved with prednisolone, the patient developed steroid dependency. Treatment with vedolizumab and ustekinumab subsequently failed to achieve clinical or endoscopic improvement. Intensive granulocyte and monocyte apheresis (GMA) was introduced, successfully inducing remission. However, during maintenance therapy with GMA, the patient experienced a relapse. Initiation of golimumab yielded suboptimal results, necessitating a combination therapy involving prednisolone and reintensified intensive GMA. This multimodal approach successfully achieved remission induction and maintenance. This case highlights the potential utility of intensive GMA in combination with golimumab and prednisolone for the management of refractory UC, particularly in patients with 5-ASA intolerance and failure of multiple biologic agents. A brief review of the relevant literature is included.<\/span><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Tomotaka Tanaka\u00a01,\u00a0Daiki Hirano\u00a01,\u00a0Syohei Ishimaru\u00a01,\u00a0Keiko Arataki\u00a01 Cureus 2025 Jan 18;17(1):e77641.\u00a0doi: 10.7759\/cureus.77641.\u00a0eCollection 2025 Jan. We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. Although induction of remission was [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[721,353,728,303,157,424,758,465,827,461,603,306],"class_list":["post-11004","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-5-asa","scientific_tags-biologic-refractory","scientific_tags-case-report","scientific_tags-combination","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-golimumab","scientific_tags-intensive","scientific_tags-intolerance","scientific_tags-refractory","scientific_tags-steroid-dependent-2","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834662\/\">Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis - PubMed<\/a>\r\n\r\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11743757\/\">Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis - PMC<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/successful-treatment-of-refractory-ulcerative-colitis-with-5-aminosalicylic-acid-intolerance-and-biologic-therapy-resistance-using-combined-granulocyte-and-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Tomotaka Tanaka\u00a01,\u00a0Daiki Hirano\u00a01,\u00a0Syohei Ishimaru\u00a01,\u00a0Keiko Arataki\u00a01 Cureus 2025 Jan 18;17(1):e77641.\u00a0doi: 10.7759\/cureus.77641.\u00a0eCollection 2025 Jan. We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. 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We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. 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