{"id":5439,"date":"2021-03-16T11:40:01","date_gmt":"2021-03-16T11:40:01","guid":{"rendered":"https:\/\/www.adacyte.com\/professional\/products\/adacolumn\/"},"modified":"2024-07-10T12:31:44","modified_gmt":"2024-07-10T10:31:44","slug":"adacolumn","status":"publish","type":"professional_product","link":"https:\/\/www.adacyte.com\/fr\/professional\/products\/adacolumn\/","title":{"rendered":"Adacolumn\u00ae"},"content":{"rendered":"<div class=\"relative max-h-768 overflow-hidden mb-0\">\n  <div class=\"absolute w-full h-full max-w-mw px-25 pb-65 flex flex-col justify-end md:left-50% md:transform md:-translate-x-50% xl:px-0 lg:pt-120 xl:pt-180\">\n    <div class=\"pb-65 lg:pb-100\">\n      <h1 class=\"text-white font-display font-bold text-36-40 uppercase mb-35 lg:text-60-70 lg:max-w-710 lg:mb-40\">Adacolumn\u00ae<\/h1>\n            <div class=\"font-body text-18-24 text-white lg:text-22-30 lg:max-w-710\">\n        <p>L\u2019aph\u00e9r\u00e8se leucocytaire (GMA) agit de mani\u00e8re sp\u00e9cifique en emp\u00eachant la migration des granulocytes (neutrophiles) et des monocytes activ\u00e9s vers la paroi intestinale<\/p>\n      <\/div>\n          <\/div>\n  <\/div>\n  <picture>\n    <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/product-hero-d@2x.jpg\" \/>\n    <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/product-hero-m@2x.jpg\" alt=\"\" title=\"product-hero-d@2x\">\n  <\/picture>\n<\/div>\n<div class=\"mb-0\">  <div id=\"product-navigation\" class=\"w-full bg-blue-d px-25 lg:px-45 mw:px-75 py-65 mw:py-80\">\n    <div class=\"w-full max-w-987 mx-auto lg:flex lg:justify-between\">\n  <ul class=\"lg:w-48%\"><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Int\u00e9r\u00eat de l\u2019utilisation de l\u2019aph\u00e9r\u00e8se leucocytaire (GMA) dans le traitement des MICI\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Int\u00e9r\u00eat de l\u2019utilisation de l\u2019aph\u00e9r\u00e8se leucocytaire (GMA) dans le traitement des MICI<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#role-of-granulocytes\" title=\"R\u00f4le des granulocytes et des monocytes dans les MICI\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">R\u00f4le des granulocytes et des monocytes dans les MICI<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#adacolumn\" title=\"Aph\u00e9r\u00e8se leucocytaire (GMA)\u00a0: Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Aph\u00e9r\u00e8se leucocytaire (GMA)\u00a0: Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#video-adacolumn\" title=\"Pr\u00e9sentation vid\u00e9o Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Pr\u00e9sentation vid\u00e9o Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#video-moa\" title=\"Video MoA Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Video MoA Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#gma-moa\" title=\"M\u00e9canisme d\u2019action de la GMA\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">M\u00e9canisme d\u2019action de la GMA<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#approved-indications\" title=\"Indications approuv\u00e9es\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Indications approuv\u00e9es<\/a><\/li><\/ul><ul class=\"lg:w-48%\"><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#patient-material\" title=\"Adacolumn\u00ae documents d\u2019information pour les patients\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Adacolumn\u00ae documents d\u2019information pour les patients<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Information et assistance technique\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Information et assistance technique<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Section scientifique\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Section scientifique<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Temps d\u2019apherese\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Temps d\u2019apherese<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#gma-safety\" title=\"Innocuit\u00e9 et contre-indications de la GMA\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Innocuit\u00e9 et contre-indications de la GMA<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#in-summary\" title=\"En r\u00e9sum\u00e9\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">En r\u00e9sum\u00e9<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#in-summary\" title=\"Mode d\u2019emploi\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Mode d\u2019emploi<\/a><\/li><\/ul>    <\/div>\n  <\/div>\n  <\/div>\n\n<div style=\"\n    width: 70%;\n\" class=\"relative overflow-hidden video-bg  mx-auto mb-65 lg:mb-115\" id=\"video-adacolumn\">\n    <div class=\"relative left-0 top-0 w-full overflow-hidden z-1\">\n    <div data-id=\"6a86e5dbc9066\" class=\"relative wp-block-embed__wrapper w-full vimeo-player vimeo-player-6a86e5dbc9066\">\n  \n    <iframe loading=\"lazy\" id=\"vimeo--iframe-6a86e5dbc9066\" src=\"https:\/\/player.vimeo.com\/video\/688326429?h=7ad370b848&amp;dnt=1&amp;app_id=122963\" width=\"640\" height=\"360\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><?h=iframe>\u00a0\u00bb width=\u00a0\u00bb640&Prime; height=\u00a0\u00bb360&Prime; frameborder=\u00a0\u00bb0&Prime; allow=\u00a0\u00bbautoplay; fullscreen; picture-in-picture\u00a0\u00bb allowfullscreen><\/iframe>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n\n\n\n\n<div class=\"max-w-mw mx-auto mb-85 lg:mb-200\" id=\"rational-adacolumn-ibd\">\n  <div class=\"flex flex-col lg:flex-row lg:justify-between\">\n\n    <div class=\"mb-75 w-full lg:mb-0 lg:max-w-430 lg:pt-75\">\n              <a href=\"https:\/\/www.adacyte.com\/fr\/professional\/products\/adacolumn\/assistance-technique\/\" title=\"INFORMATION ET ASSISTANCE TECHNIQUE\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">INFORMATION ET ASSISTANCE TECHNIQUE<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n                <a href=\"https:\/\/www.adacyte.com\/fr\/professionnels\/temps-dapherese\/\" title=\"TEMPS D&rsquo;APHERESE\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">TEMPS D&rsquo;APHERESE<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n                <a href=\"https:\/\/www.adacyte.com\/fr\/professionnels\/section-scientifique\/\" title=\"Section scientifique\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">Section scientifique<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n            <\/div>\n\n    <div class=\"text-18-24 max-w-586 font-body text-blue-d lg:text-18-28 lg:mr-45\">\n      <h2 class=\"font-display text-blue-l text-36-42 mb-45 lg:mb-70 lg:text-36-42\">Int\u00e9r\u00eat de l\u2019utilisation de l\u2019aph\u00e9r\u00e8se leucocytaire (GMA) dans le traitement des MICI<\/h2>\n      <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28\">\n        <p class=\"p1\">Dans tous les cas de maladies m\u00e9di\u00e9es par le syst\u00e8me immunitaire, on observe une \u00e9tape initiale indispensable \u00e0 l\u2019apparition de l\u2019inflammation dans l\u2019organe concern\u00e9\u00a0: le recrutement de cellules inflammatoires depuis le flux sanguin vers les tissus enflamm\u00e9s.<\/p>\n<p class=\"p1\">Une fois sur place, ces cellules inflammatoires s\u00e9cr\u00e8tent diverses substances dont la fonction sera d\u2019une part, de recruter d\u2019autres cellules inflammatoires, et d\u2019autre part, de g\u00e9n\u00e9rer les l\u00e9sions tissulaires caract\u00e9ristiques de chaque maladie.<\/p>\n<p class=\"p1\">Au d\u00e9part, le traitement contre ces maladies reposait sur l\u2019administration de corticost\u00e9ro\u00efdes et d\u2019immunosuppresseurs non s\u00e9lectifs, qui agissaient \u00e0 diff\u00e9rents niveaux et entra\u00eenaient un taux \u00e9lev\u00e9 d\u2019effets ind\u00e9sirables.<\/p>\n<p class=\"p1\">Au cours des deux derni\u00e8res d\u00e9cennies, ce traitement a \u00e9volu\u00e9 vers l\u2019utilisation de m\u00e9dicaments beaucoup plus s\u00e9lectifs, dont les effets th\u00e9rapeutiques comme ind\u00e9sirables \u00e9taient davantage pr\u00e9visibles.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n  <div class=\"max-w-mw mx-auto mb-85 px-25 lg:px-0 lg:mb-200\" id=\"role-of-granulocytes\">\n          <h2 class=\"font-display text-blue-l text-36-42 max-w-944 mb-45 lg:mb-70 lg:text-36-42 lg:pl-157\">R\u00f4le des granulocytes et des monocytes dans les MICI<\/h2>\n        <div class=\"lg:flex lg:flex-row-reverse lg:justify-between\">\n              <picture class=\"lg:pt-130 mb-85 block max-w-374 lg:w-57%\">\n          <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/05\/gobulos_blancos-1.jpg\" \/>\n          <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/05\/gobulos_blancos-1.jpg\" alt=\"\" title=\"gobulos_blancos\">\n        <\/picture>\n            <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28 max-w-586 lg:ml-157\">\n        <p class=\"p1\">Dans le cas des maladies inflammatoires chroniques de l\u2019intestin (MICI), m\u00eame si d\u2019autres cellules comme les lymphocytes ou les monocytes jouent un certain r\u00f4le, les principales cellules impliqu\u00e9es dans les m\u00e9canismes pathog\u00e9niques sont les neutrophiles, des globules blancs aussi appel\u00e9s granulocytes.<\/p>\n<p class=\"p1\">Les neutrophiles sont activement recrut\u00e9s depuis le flux sanguin, d\u2019o\u00f9 ils rejoignent la muqueuse intestinale et causent les l\u00e9sions caract\u00e9ristiques de la maladie via la d\u00e9granulation et la lib\u00e9ration de diverses prot\u00e9inases et chimiokines.<\/p>\n<p class=\"p1\">L\u2019importance des neutrophiles est telle dans cette maladie que plusieurs \u00e9tudes ont d\u00e9montr\u00e9 une \u00e9troite corr\u00e9lation entre la pr\u00e9sence de neutrophiles dans la paroi intestinale des patients atteints de MICI et le risque de rechute (\u00ab\u00a0pouss\u00e9e\u00a0\u00bb de la maladie) ou de cancer du c\u00f4lon.<\/p>\n<p class=\"p1\">L\u2019utilit\u00e9 de l\u2019\u00e9valuation de la calprotectine f\u00e9cale pour anticiper les rechutes ou \u00e9mettre un pronostic concernant l\u2019activit\u00e9 de la maladie, m\u00eame en l\u2019absence de sympt\u00f4mes, constitue un autre facteur qui d\u00e9montre l\u2019importance de la pr\u00e9sence des neutrophiles dans la paroi intestinale des patients atteints de MICI. En effet, la calprotectine f\u00e9cale est la principale prot\u00e9ine contenue dans le cytoplasme des neutrophiles et elle est d\u00e9tectable dans les selles lorsque la muqueuse intestinale est infiltr\u00e9e par les neutrophiles. Les caract\u00e9ristiques physicochimiques de cette prot\u00e9ine et sa r\u00e9sistance \u00e0 la d\u00e9gradation par les bact\u00e9ries du c\u00f4lon permettent de l\u2019utiliser dans la pratique clinique.Elles font de cette prot\u00e9ine le param\u00e8tre le plus surveill\u00e9 et le plus fiable pour la gestion et l\u2019\u00e9valuation de patients souffrant de MICI, notamment de RCH.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div id=\"video-moa\" class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"MoA Granulocyte Monocyte Adsorption Apheresis\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/kWtkZytgVUk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\"><em>MoA Granulocyte Monocyte Adsorption Apheresis<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n  <div class=\"max-w-mw mx-auto mb-85 px-25 lg:px-0 lg:mb-200\" id=\"adacolumn\">\n          <h2 class=\"font-display text-blue-l text-36-42 max-w-944 mb-45 lg:mb-70 lg:text-36-42 lg:pl-157\">Aph\u00e9r\u00e8se leucocytaire (GMA)\u00a0: Adacolumn\u00ae<\/h2>\n        <div class=\"flex flex-col lg:flex-row\">\n              <picture class=\"order-2 lg:order-1 lg:mr-98 mb-85 block max-w-374 lg:w-57%\">\n          <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/neutrofilos_monocitos.jpg\" \/>\n          <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/neutrofilos_monocitos.jpg\" alt=\"\" title=\"neutrofilos_monocitos\">\n        <\/picture>\n            <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28flex-col-reverse max-w-586 lg:order-2\">\n        <p>L\u2019aph\u00e9r\u00e8se leucocytaire (GMA) agit de mani\u00e8re sp\u00e9cifique en emp\u00eachant la migration des granulocytes (neutrophiles) et des monocytes activ\u00e9s vers la paroi intestinale (1). Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que les billes d\u2019ac\u00e9tate de cellulose de <strong>l\u2019Adacolumn\u00ae<\/strong> absorbent les complexes immuns circulants et les IgG et activent certains composants du syst\u00e8me du compl\u00e9ment (notamment C3a et C5a). Cela permet au syst\u00e8me d\u2019absorber de mani\u00e8re s\u00e9lective les granulocytes (via les r\u00e9cepteurs Fc) et les monocytes (via les r\u00e9cepteurs du compl\u00e9ment).<\/p>\n<p>En plus de cet \u00ab\u00a0effet m\u00e9canique\u00a0\u00bb, il a \u00e9t\u00e9 d\u00e9montr\u00e9 que les billes de cellulose sont \u00e9galement capables d\u2019activer l\u2019apoptose des neutrophiles (plus faible que la normale dans les cas de RCH). Plusieurs \u00e9tudes ont d\u00e9montr\u00e9 que les billes de cellulose ainsi que la pr\u00e9sence de neutrophiles apoptotiques augmentent \u00e9galement la synth\u00e8se de cytokines anti-inflammatoires (IL-10, IL-1ra, HGF) et r\u00e9duisent la synth\u00e8se de cytokines pro-inflammatoires (TNF-\u03b1, IL-6, IL-8, IL-1\u03b2) (2).<\/p>\n<p>\u00c9tant donn\u00e9 que des globules blancs sont mobilis\u00e9s en continu depuis la moelle osseuse, ce \u00ab\u00a0retrait\u00a0\u00bb de neutrophiles et de monocytes activ\u00e9s du flux sanguin n\u2019entra\u00eene pas une r\u00e9duction du nombre total de ces cellules dans le sang, car elles sont remplac\u00e9es par des cellules immatures ou inactives.<\/p>\n<p>Cela pourrait expliquer pourquoi l\u2019utilisation de la GMA ne s\u2019accompagne pas d\u2019une hausse du risque d\u2019infection ou de tumeur comme c\u2019est le cas avec les immunosuppresseurs (1). <small>1.- <span style=\"color: #3ab0c8;\">Hanai H1, Takeda Y, Eberhardson M, Gruber R, Saniabadi AR, Winqvist O, Lofberg R.<\/span> <strong>The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review<\/strong>, <span style=\"color: #3ab0c8;\">Clin Exp Immunol<\/span>. <strong>2011 Jan;163(1):50-8.DOI: 10.1111\/j.1365-2249.2010.04279.x. 2.-<\/strong> <span style=\"color: #3ab0c8;\">Saniabadi AR1, Hanai H, Takeuchi K, Umemura K, Nakashima M, Adachi T, Shima C, Bjarnason I, Lofberg R<\/span>. <strong>Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes.<\/strong> <span style=\"color: #3ab0c8;\">Ther Apher Dial<\/span>. <strong>2003 Feb;7(1):48-59. DOI\u00a0:<\/strong><span style=\"color: #3ab0c8;\">10.1046\/j.1526-0968.2003.00012.x<\/span><\/small><\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n  <div class=\"relative\">\n    <picture class=\" max-w-200 lg:max-w-374 lg:w-57% lg:mr-98 lg:pt-50\">\n      <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/blood-cells-color-d@2x.jpg\" \/>\n      <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/blood-cells-color-m@2x.jpg\" alt=\"\" title=\"blood-cells-color-d@2x\">\n    <\/picture>\n  <\/div>\n\n\n  <div class=\"max-w-mw mx-auto px-25 mb-85 pt-55 lg:px-0 lg:mb-200\" id=\"gma-moa\">\n        <p class=\"text-18-40 text-blue-l font-body lg:text-15-20\">APER\u00c7U GLOBAL<\/p>\n    \n        <h2 class=\"text-36-40 text-blue-d font-display uppercase font-bold max-w-400 lg:text-40-47\">M\u00e9canisme d\u2019action de la GMA (1)<\/h2>\n    \n    <div class=\"relative flex flex-col items-center md:justify-center\">\n      <img decoding=\"async\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/adacolum-product@2x.png\" alt=\"\" title=\"adacolum-product@2x\" class=\"max-w-1\/2 mb-45 lg:max-w-232\">\n              <ul class=\"lg:absolute lg:left-0 lg:top-0 lg:w-full\">\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-37 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-01@2x.png\" alt=\"\" title=\"gma-01@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Activation de composants du syst\u00e8me du compl\u00e9ment (C3a, C5a).<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:left-50% lg:top-120 lg:-translate-x-430\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-02@2x.png\" alt=\"\" title=\"gma-02@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Adsorption des IgG et des complexes immuns circulants par les billes d\u2019ac\u00e9tate de cellulose.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-160 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-03@2x.png\" alt=\"\" title=\"gma-03@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Absorption des granulocytes et des monocytes via (1) les r\u00e9cepteurs Fc (IgG et complexes immuns) et (2) les sites de liaison des r\u00e9cepteurs du compl\u00e9ment des leucocytes (absents chez les lymphocytes).<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:transform lg:left-50% lg:top-258 lg:-translate-x-430\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-04@2x.png\" alt=\"\" title=\"gma-04@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Baisse du nombre de neutrophiles et de monocytes activ\u00e9s.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-290 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-05@2x.png\" alt=\"\" title=\"gma-05@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Les CA interagissent avec les lymphocytes B r\u00e9gulateurs, ce qui permet la production d\u2019IL-10 et de lymphocytes B r\u00e9gulateurs matures.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:left-50% lg:top-365 lg:-translate-x-465\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-06@2x-1.png\" alt=\"\" title=\"gma-06@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Retour de substances lib\u00e9r\u00e9es par les cellules absorb\u00e9es\u00a0: de l\u2019IL-1ra (contr\u00f4le de l\u2019inflammation intestinale) et du HGF (r\u00e9paration de l\u2019\u00e9pith\u00e9lium de la muqueuse). <\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-435 lg:-translate-x-30\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-07@2x.png\" alt=\"\" title=\"gma-07@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">G\u00e9n\u00e9ration de cellules apoptotiques (CA), principalement des neutrophiles, dont > 40\u00a0% retournent dans le flux sanguin du patient.<\/span>\n          <\/li>\n                <\/ul>\n          <\/div>\n  <\/div>\n\n\n<div class=\"max-w-987 mx-auto mb-85 px-20 lg:px-0 md:flex md:flex-wrap md:justify-between pt-65 lg:pt-100 lg:mb-200\" id=\"en-savoir-plus-sur-le-mcanisme-daction-de-ladacolumn\">\n\n      <p class=\"text-blue-d font-display font-bold text-28-33 mb-45 md:mb-75\">EN SAVOIR PLUS SUR LE M\u00c9CANISME D\u2019ACTION DE L\u2019ADACOLUMN\u00ae<\/p>\n    \n    <ul class=\"w-full md:flex md:flex-wrap md:justify-between\">\n\n          <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-0920031-ADACOLUMN-MoA-BROCHURE-ENGLISH.pdf\" target=\"_blank\" title=\"M\u00e9canisme d\u2019action de l\u2019Adacolumn\u00ae\u00a0:\u00a0immunophysiologie et explications des experts (vol. I)\">M\u00e9canisme d\u2019action de l\u2019Adacolumn\u00ae\u00a0:\u00a0immunophysiologie et explications des experts (vol. I)<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n            <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-0920031A-ADACOLUMN-MOA-BROCHURE-ENGLISH-BAMIAS-JOANA-TORRES-1.pdf\" target=\"_blank\" title=\"M\u00e9canisme d\u2019action de l\u2019Adacolumn\u00ae\u00a0:\u00a0immunophysiologie et explications des experts (vol. II)\">M\u00e9canisme d\u2019action de l\u2019Adacolumn\u00ae\u00a0:\u00a0immunophysiologie et explications des experts (vol. II)<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n          <\/ul>\n    <\/div>\n\n\n<div class=\"block--cols-manually bg-white\" id=\"approved-indications\">\n\n  <div class=\"max-w-1366 mx-auto px-25 lg:px-75 py-65 lg:py-100\">\n\n        <div class=\"lg:flex lg:justify-between\">\n      <h2 class=\"lg:w-48% lg:max-w-586 font-display text-blue-l text-30-35 mb-45 lg:text-36-42\">Indications approuv\u00e9es<\/h2>\n    <\/div>\n    \n    <div class=\"block--cols-manually-content  lg:flex lg:justify-between\">\n      <div class=\"lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28\">\n        <p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Adacolumn<sup>\u00ae<\/sup> est un dispositif m\u00e9dical approuv\u00e9 pour\u00a0:<\/p>\n<ul>\n<li>L\u2019induction d\u2019une r\u00e9mission chez les patients souffrant d\u2019une maladie inflammatoire chronique de l\u2019intestin (rectocolite h\u00e9morragique active et maladie de Crohn).<\/li>\n<li>La suppression des sympt\u00f4mes objectifs et subjectifs chez les patients souffrant de polyarthrite rhumato\u00efde au stade inflammatoire et dont les sympt\u00f4mes seraient r\u00e9sistants aux traitements m\u00e9dicamenteux standard.<\/li>\n<li>Le traitement des patients souffrant des manifestations oculaires de la maladie de Beh\u00e7et.<\/li>\n<li>Le traitement des patients souffrant d\u2019un lupus \u00e9ryth\u00e9mateux syst\u00e9mique (LES).<\/li>\n<li>L\u2019am\u00e9lioration des sympt\u00f4mes cliniques des patients souffrant de psoriasis pustuleux (PP).<\/li>\n<\/ul>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Marquage CE\u00a0: CE 0123 par T\u00dcV S\u00dcD, classe IIb.<\/p>\n      <\/div>\n\n      <div class=\"block--cols-manually-content lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28 pt-25 lg:pt-0\">\n              <\/div>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"block--cols-manually bg-white\" id=\"gma-safety\">\n\n  <div class=\"max-w-1366 mx-auto px-25 lg:px-75 py-65 lg:py-100\">\n\n        <div class=\"lg:flex lg:justify-between\">\n      <h2 class=\"lg:w-48% lg:max-w-586 font-display text-blue-l text-30-35 mb-45 lg:text-36-42\">Innocuit\u00e9 et contre-indications de la GMA<\/h2>\n    <\/div>\n    \n    <div class=\"block--cols-manually-content  lg:flex lg:justify-between\">\n      <div class=\"lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28\">\n              <\/div>\n\n      <div class=\"block--cols-manually-content lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28 pt-25 lg:pt-0\">\n        <p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">La GMA est une technique s\u00fbre. Les effets secondaires ne touchent qu\u2019une faible proportion de patients (entre 1 et 15\u00a0%) et sont g\u00e9n\u00e9ralement l\u00e9gers et temporaires. Les plus courants sont les maux de t\u00eate, les vertiges, la fatigue, les douleurs musculaires, les rougeurs au niveau du visage, les baisses de tension, les palpitations, etc.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Les contre-indications sont rares.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Cette proc\u00e9dure peut \u00eatre contre-indiqu\u00e9e aux patients allergiques \u00e0 l\u2019h\u00e9parine (utilis\u00e9e pour \u00e9viter que le sang ne coagule dans le circuit) et \u00e0 ceux pr\u00e9sentant un faible nombre de plaquettes.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">De plus, des pr\u00e9cautions doivent \u00eatre prises chez les patients pr\u00e9sentant un faible nombre de leucocytes, une an\u00e9mie s\u00e9v\u00e8re, un infection, une d\u00e9faillance cardiaque ou r\u00e9nale s\u00e9v\u00e8re, une coagulopathie ou une d\u00e9shydratation.<\/p>\n      <\/div>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"bg-blue-l pt-45 pb-50 px-25 lg:py-85 lg:px-0\" id=\"in-summary\">\n  <div class=\"max-w-mw mx-auto lg:flex lg:justify-between lg:items-end\">\n    <div class=\"max-w-574\">\n      <p class=\"font-display font-bold text-blue-d uppercase mb-35 text-36-40 mb-45 lg:text-36-42\">En r\u00e9sum\u00e9,<\/p>\n      <div class=\"summary-content font-body text-white text-18-29\">\n        <p>la GMA permet (1)\u00a0:<\/p>\n<p>\u2022 une baisse du nombre de neutrophiles et de monocytes activ\u00e9s dans le flux sanguin.<br \/>\n\u2022 une hausse des cytokines anti-inflammatoires.<br \/>\n\u2022 une baisse des cytokines pro-inflammatoires.<\/p>\n<p>Tous ces m\u00e9canismes n\u2019induisent pas une immunosuppression.<\/p>\n<p>L\u2019Adacolumn\u00ae est un dispositif m\u00e9dical de classe IIb destin\u00e9 \u00e0 r\u00e9aliser une aph\u00e9r\u00e8se leucocytaire s\u00e9lective afin d\u2019\u00e9liminer de mani\u00e8re th\u00e9rapeutique les granulocytes et les monocytes\/macrophages du sang p\u00e9riph\u00e9rique.<\/p>\n<p>L\u2019Adacolumn\u00ae est approuv\u00e9 au Japon et dans l\u2019Union Europ\u00e9enne depuis 1999 et en Chine depuis 2011.<\/p>\n      <\/div>\n    <\/div>\n        <a href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2024\/01\/Adacolumn-IFU_9_fr_59-17.pdf\" title=\"Adacolumn IFU_1_en_63-18\" class=\"inline-block uppercase bg-white text-blue-d py-20 pl-30 pr-30 font-display font-bold text-16-40 lg:min-w-270 hover-fill-blue-l\" target=\"_blank\">MODE D\u2019EMPLOI<\/a>\n      <\/div>\n<\/div>\n\n\n<div class=\"max-w-987 mx-auto mb-85 px-20 lg:px-0 md:flex md:flex-wrap md:justify-between pt-65 lg:pt-100 lg:mb-200\" id=\"patient-material\">\n\n      <p class=\"text-blue-d font-display font-bold text-28-33 mb-45 md:mb-75\">ADACOLUMN\u00ae DOCUMENTS D\u2019INFORMATION POUR LES PATIENTS<\/p>\n    \n    <ul class=\"w-full md:flex md:flex-wrap md:justify-between\">\n\n          <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2024\/07\/FR-ADA-1020037A-BROCHURE-FOR-PATIENTS-FRANCE-GMA-IN-IBD-PATIENT.pdf\" target=\"_blank\" title=\"Mat\u00e9riel d\u2019information Adacolumn\u00ae pour les patients atteints de mici\">Mat\u00e9riel d\u2019information Adacolumn\u00ae pour les patients atteints de mici<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n            <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2024\/07\/FR-ADA-1020037-BROCHURE-FOR-PATIENTS-FRANCE-GMA-IN-RHUMATOID-ARTHRITIS.pdf\" target=\"_blank\" title=\"at\u00e9riel d\u2019information Adacolumn\u00ae pour les patients atteints de polyarthrite rhumato\u00efde\">at\u00e9riel d\u2019information Adacolumn\u00ae pour les patients atteints de polyarthrite rhumato\u00efde<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n          <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>The rationale for the use of granulocyte-monocyte apheresis (GMA) in the treatment of IBD<\/p>\n","protected":false},"parent":0,"menu_order":0,"template":"","class_list":["post-5439","professional_product","type-professional_product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adacolumn\u00ae - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/fr\/professional\/products\/adacolumn\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adacolumn\u00ae - Adacyte\" \/>\n<meta property=\"og:description\" content=\"The rationale for the use of granulocyte-monocyte apheresis (GMA) in the treatment of IBD\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/fr\/professional\/products\/adacolumn\/\" 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