{"id":9975,"date":"2023-07-07T14:23:00","date_gmt":"2023-07-07T12:23:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9975"},"modified":"2024-03-27T14:27:49","modified_gmt":"2024-03-27T13:27:49","slug":"intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/","title":{"rendered":"Intracellular DNA sensing by neutrophils and amplification of the innate immune response"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">Arun K. Mankan, Paulina Czajka-Francuz, Maria Prendes, Sriram Ramanan, Marcin Koziej, Laura Vidal, Kamal S. Saini Front. Immunol., 2023, 14, doi.org=10.3389\/fimmu.2023.1208137<\/p>\n<p>As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production of ROS, and the secretion of neutrophil extracellular traps (NETs). Only recently, the ability of neutrophils to sense and respond to pathogen-associated molecular patterns is being appreciated. This review brings together the current information about the intracellular recognition of DNA by neutrophils and proposes models of signal amplification in immune response. Finally, the clinical relevance of DNA sensing by neutrophils in infectious and non-infectious diseases including malignancy are also discussed.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Arun K. Mankan, Paulina Czajka-Francuz, Maria Prendes, Sriram Ramanan, Marcin Koziej, Laura Vidal, Kamal S. Saini Front. Immunol., 2023, 14, doi.org=10.3389\/fimmu.2023.1208137 As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[424,808,445,790,196],"class_list":["post-9975","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-gma","scientific_tags-innate-immunity","scientific_tags-neutrophil","scientific_tags-plaque-skin-lesions","scientific_tags-psoriasis"],"acf":{"sc_authors":"<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1208137\/full\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1208137\/full<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Intracellular DNA sensing by neutrophils and amplification of the innate immune response - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intracellular DNA sensing by neutrophils and amplification of the innate immune response - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Arun K. Mankan, Paulina Czajka-Francuz, Maria Prendes, Sriram Ramanan, Marcin Koziej, Laura Vidal, Kamal S. Saini Front. Immunol., 2023, 14, doi.org=10.3389\/fimmu.2023.1208137 As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T13:27:49+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/\",\"name\":\"Intracellular DNA sensing by neutrophils and amplification of the innate immune response - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2023-07-07T12:23:00+00:00\",\"dateModified\":\"2024-03-27T13:27:49+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intracellular DNA sensing by neutrophils and amplification of the innate immune response - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intracellular-dna-sensing-by-neutrophils-and-amplification-of-the-innate-immune-response\/","og_locale":"es_ES","og_type":"article","og_title":"Intracellular DNA sensing by neutrophils and amplification of the innate immune response - Adacyte","og_description":"Arun K. Mankan, Paulina Czajka-Francuz, Maria Prendes, Sriram Ramanan, Marcin Koziej, Laura Vidal, Kamal S. Saini Front. Immunol., 2023, 14, doi.org=10.3389\/fimmu.2023.1208137 As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. 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