{"id":9973,"date":"2024-03-19T14:11:00","date_gmt":"2024-03-19T13:11:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9973"},"modified":"2024-03-27T14:15:15","modified_gmt":"2024-03-27T13:15:15","slug":"case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/","title":{"rendered":"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou,Miao Zhang, Mengxue Liao,Lirong Liu,Mengya Huang, Front. Immunol. 2024, 15,doi.org=10.3389\/fimmu.2024.1354578<\/p>\n<p>Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage 4 chronic kidney disease (CKD), type 2 diabetes, and cardiovascular disease, in whom skin symptom disappearance and kidney function improvement were observed after the use of oral tacrolimus as the sole therapy. This is the first report on the application of tacrolimus in the treatment of acute GPP, especially refractory acute GPP. The successful treatment indicates that there are shared immune pathways between acute GPP and CKD, and the pathways can be interdicted by tacrolimus. Further studies are needed to optimize the therapy to maximize efficacy and minimize toxicity.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou,Miao Zhang, Mengxue Liao,Lirong Liu,Mengya Huang, Front. Immunol. 2024, 15,doi.org=10.3389\/fimmu.2024.1354578 Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[728,699,64,348,424,53,352],"class_list":["post-9973","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-case-report","scientific_tags-comorbidities","scientific_tags-frail","scientific_tags-generalized-pustular-psoriasis","scientific_tags-gma","scientific_tags-refractory-patients","scientific_tags-tacrolimus"],"acf":{"sc_authors":"<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2024.1354578\/full\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2024.1354578\/full<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou,Miao Zhang, Mengxue Liao,Lirong Liu,Mengya Huang, Front. Immunol. 2024, 15,doi.org=10.3389\/fimmu.2024.1354578 Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T13:15:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/\",\"name\":\"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-03-19T13:11:00+00:00\",\"dateModified\":\"2024-03-27T13:15:15+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/","og_locale":"es_ES","og_type":"article","og_title":"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte","og_description":"Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou,Miao Zhang, Mengxue Liao,Lirong Liu,Mengya Huang, Front. Immunol. 2024, 15,doi.org=10.3389\/fimmu.2024.1354578 Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/","og_site_name":"Adacyte","article_modified_time":"2024-03-27T13:15:15+00:00","twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/","name":"Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2024-03-19T13:11:00+00:00","dateModified":"2024-03-27T13:15:15+00:00","inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/case-report-successful-treatment-of-acute-generalized-pustular-psoriasis-with-multiple-comorbidities-with-oral-tacrolimus\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner\/9973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/media?parent=9973"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific_tags?post=9973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}