{"id":9967,"date":"2024-01-24T13:34:00","date_gmt":"2024-01-24T12:34:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9967"},"modified":"2024-03-27T13:43:11","modified_gmt":"2024-03-27T12:43:11","slug":"p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/","title":{"rendered":"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">I Rodr\u00edguez-Lago, D Ginard, R J D\u00edaz Molina, M Vicu\u00f1a, E Domenech, M Abanades, O Moralejo Lozano, G Bastida, A D S\u00e1nchez Capilla, E Iglesias, F Rancel-Medina, M D M Blasco, M Bosca-Watts, M Calvo I\u00f1iguez, C Herrera deGuis\u00e9, E Leo, A Viejo Almanzor, V Hern\u00e1ndez Ramirez, C Su\u00e1rez Ferrer, L Quilez P\u00e9rez, M Mu\u00f1oz, F Fern\u00e1ndez P\u00e9rez, J M Huguet, P Fradejas, C L\u00f3pez Ramos, A M Fuentes Coronel, C Reygosa Castro, N Rull Murillo, P Zapico, J L Cabriada<br \/>\nJournal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i1011, doi.org=10.1093\/ecco-jcc\/jjad212.0641<\/p>\n<p>Background<br \/>\nThe clinical efficacy of granulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn in patients (pts) with inflammatory bowel disease (IBD) has been reported in several clinical trials (CT), with significant clinical remission rates. However, evidence on real-world effectiveness of GMA with Adacolumn in ulcerative colitis (UC) or Crohn&#8217;s disease (CD) patients who were underrepresented in CT is still limited.<\/p>\n<p>Methods<br \/>\nGRACE is a multicentric, prospective observational study conducted at 31 centres in Spain. The study included adults (\u226518 years) diagnosed with UC or CD who had been scheduled to receive GMA with Adacolumn in clinical practice. The study consisted of a baseline (GMA initiation) and 3 follow-up visits at 4, 24, and 48 weeks after the last GMA session. The primary endpoint is the steroid-free remission rate at 24 weeks. This interim analysis is focused on clinical characterization of patients and their management and outcome 4 weeks after GMA treatment.<\/p>\n<p>Results<br \/>\nA total of 95 evaluable patients were included at data cut-off date (25 Sept 2023) (median age: 54 years; 50% men: 81% outpatients). Overall, 89.4% (n=84) of patients had UC, being moderate-to-severe in 85.5%; 57,8% had pancolitis, and the median Mayo score was 5 (interquartile range [IQR], 3-6). Out of the 10 patients (10.6%) with CD, all had B1, and 3 patients had L1, 4 L2 and 3 L3. Overall, 17% had extraintestinal manifestations. Regarding IBD-related therapy, 52.6% of patients had previously received anti-TNF agents, 37.9% thiopurines, and 17.8% JAK inhibitors. Overall, 85.3% of patients received concomitant treatment with GMA, most commonly 5-ASA (60%), corticosteroids (51,6%), ustekinumab (20%), vedolizumab (17.9%), and anti-TNF therapy (11.6%). A total of 71 patients reached the 4-week visit after receiving a median of 10 (IQR, 8-10) GMA sessions (weekly: 26.3%, biweekly: 36.8%, and weekly\/biweekly: 31.6%). At week 4, clinical remission was achieved by 50.7% of patients (UC: 49.2%; CD: 66.7%), being 50% and 53.3% in patients concomitantly treated with ustekinumab and vedolizumab. Steroid-free remission rate was 26.1% (UC: 22.2%; CD: 66.7%) at week 4. Overall, 11,2% of patients experienced AEs related to GMA, most of them being mild (73%) or moderate (22.4%). Most common AEs were headache and asthenia. No SAEs were observed.<\/p>\n<p>Conclusion<br \/>\nPreliminary data at 4 weeks show that Adacolumn is a safe and effective treatment in a cohort of IBD refractory patients with previous failure to multiple therapies including thiopurines, biologics and JAK inhibitors. Half of patients were concomitantly treated with biologics, and their clinical remission rate was similar to the overall population. Long-term results of this study (48 weeks) are required to confirm these findings.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>I Rodr\u00edguez-Lago, D Ginard, R J D\u00edaz Molina, M Vicu\u00f1a, E Domenech, M Abanades, O Moralejo Lozano, G Bastida, A D S\u00e1nchez Capilla, E Iglesias, F Rancel-Medina, M D M Blasco, M Bosca-Watts, M Calvo I\u00f1iguez, C Herrera deGuis\u00e9, E Leo, A Viejo Almanzor, V Hern\u00e1ndez Ramirez, C Su\u00e1rez Ferrer, L Quilez P\u00e9rez, M Mu\u00f1oz, [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,303,159,446,526,424,426,451,465,627,100,269,97,49,53,156,522,334,271,306],"class_list":["post-9967","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-combination","scientific_tags-crohns-disease","scientific_tags-effectiveness","scientific_tags-eim","scientific_tags-gma","scientific_tags-ibd","scientific_tags-induction","scientific_tags-intensive","scientific_tags-moderate-to-severe","scientific_tags-multicenter","scientific_tags-observational","scientific_tags-prospective","scientific_tags-real-world","scientific_tags-refractory-patients","scientific_tags-safety","scientific_tags-short-term-outcome","scientific_tags-steroid-free-remission","scientific_tags-study","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"I Rodr\u00edguez-Lago, D Ginard, R J D\u00edaz Molina, M Vicu\u00f1a, E Domenech, M Abanades, O Moralejo Lozano, G Bastida, A D S\u00e1nchez Capilla, E Iglesias, F Rancel-Medina, M D M Blasco, M Bosca-Watts, M Calvo I\u00f1iguez, C Herrera deGuis\u00e9, E Leo, A Viejo Almanzor, V Hern\u00e1ndez Ramirez, C Su\u00e1rez Ferrer, L Quilez P\u00e9rez, M Mu\u00f1oz, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T12:43:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/\",\"name\":\"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-24T12:34:00+00:00\",\"dateModified\":\"2024-03-27T12:43:11+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/","og_locale":"es_ES","og_type":"article","og_title":"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte","og_description":"I Rodr\u00edguez-Lago, D Ginard, R J D\u00edaz Molina, M Vicu\u00f1a, E Domenech, M Abanades, O Moralejo Lozano, G Bastida, A D S\u00e1nchez Capilla, E Iglesias, F Rancel-Medina, M D M Blasco, M Bosca-Watts, M Calvo I\u00f1iguez, C Herrera deGuis\u00e9, E Leo, A Viejo Almanzor, V Hern\u00e1ndez Ramirez, C Su\u00e1rez Ferrer, L Quilez P\u00e9rez, M Mu\u00f1oz, [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/","og_site_name":"Adacyte","article_modified_time":"2024-03-27T12:43:11+00:00","twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/","name":"P511 Short-term real-world effectiveness and safety of granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: GRACE Study - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2024-01-24T12:34:00+00:00","dateModified":"2024-03-27T12:43:11+00:00","inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/p511-short-term-real-world-effectiveness-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-grace-study\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner\/9967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/media?parent=9967"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific_tags?post=9967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}