{"id":9966,"date":"2024-01-24T13:29:00","date_gmt":"2024-01-24T12:29:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9966"},"modified":"2024-03-27T13:34:34","modified_gmt":"2024-03-27T12:34:34","slug":"p996-clinical-efficacy-and-predictive-factors-for-the-effectiveness-of-granulocyte-and-monocyte-adsorption-apheresis-therapy-for-ulcerative-colitis%ef%bc%9aa-retrospective-observational-single-center","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/p996-clinical-efficacy-and-predictive-factors-for-the-effectiveness-of-granulocyte-and-monocyte-adsorption-apheresis-therapy-for-ulcerative-colitis%ef%bc%9aa-retrospective-observational-single-center\/","title":{"rendered":"P996 Clinical Efficacy and Predictive Factors for the Effectiveness of Granulocyte and Monocyte Adsorption Apheresis Therapy for Ulcerative Colitis\uff1aA Retrospective Observational Single Center Study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">F Kenta, S Kensuke, T Shun, W Ryosuke, N Yusuke, Y Ren, S Kentaro, S Itsuki, O Hisashi, M Takuto<br \/>\nJournal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i1807, doi.org=10.1093\/ecco-jcc\/jjad212.1126<\/p>\n<p>Background<br \/>\nGranulocyte and Monocyte Adsorption Apheresis (GMA) is one of the valuable non-immunosuppressive therapies in the treatment of ulcerative colitis (UC). However, due to the limited number of facilities where GMA can be performed, there are few reports on the combined effects of GMA and prednisolone (PSL), the frequency of GMA implementation or predictive factors for the effectiveness. In this study, we examined the combined effect of GMA and PSL as a remission induction therapy, the frequency of GMA and predictive factors.<\/p>\n<p>Methods<br \/>\nA retrospective observational study was conducted at Kushiro Rosai Hospital. We analyzed clinical data from UC patients who underwent GMA from February 2015 to May 2023.<\/p>\n<p>Results<br \/>\nThe study included 54 patients (30 males and 24 females), with a median age of 48 years and a median disease duration of 2 years. The median Lichtiger-CAI (L-CAI) was 8. There were 43 patients of pancolitis. There were 51 biologics-na\u00efve patients and 3 biologics-experienced patients. Concomitant medications included 5-ASA agents in 21 patients, immunomodulators in 7 patients, and PSL in 31 patients. The median CRP was 1.19 mg\/dl and the median albumin was 3.5 g\/dl. Adverse events were observed in 3 patients (fatigue, dizziness, palpitations). The median number of GMA sessions was 10, with 33 patients undergoing twice weekly and 9 patients three times weekly. The clinical remission rate was 80% (43\/54), and the clinical response rate was 89% (48\/54), with a significant improvement in the median L-CAI from 8 to 3 before and after GMA (P<0.001). In the comparison between the PSL concomitant group and the non-PSL group, the clinical remission rate was 83.9% (26\/31) in PSL group and 73.9% (17\/23) in non-PSLgroup (P=0.369). The clinical response rate was significantly higher in the PSL group (87% (27\/31)) than in non-PSL group (52.2% (12\/23)) (P=0.004). There was no significant difference in the clinical remission\/response rate between the group that underwent GMA twice a week (76.9% (30\/39)\/84.6% (33\/39)) and three times a week (77.8% (7\/9)\/77.8% (7\/9)). In univariate analysis, biologics-na\u00efve was extracted as a contributing factor to clinical remission. The cumulative remission rate at 52 weeks was 72% overall. There was no significant difference in the cumulative remission rate between the PSL group (76.8%) and the non-PSL group (67.6%) (P=0.524). There was also no significant difference between the twice-weekly group (75%) and the three-times-weekly group (57.1%) (P=0.236).\n\nConclusion\nGMA for UC was found to be useful and safely performed as a remission induction therapy. Concomitant use of PSL increased the clinical response rate. The frequency of GMA showed that three times per week was as effective as two times per week.\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>F Kenta, S Kensuke, T Shun, W Ryosuke, N Yusuke, Y Ren, S Kentaro, S Itsuki, O Hisashi, M Takuto Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i1807, doi.org=10.1093\/ecco-jcc\/jjad212.1126 Background Granulocyte and Monocyte Adsorption Apheresis (GMA) is one of the valuable non-immunosuppressive therapies in the treatment of ulcerative colitis (UC). [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[186,147,594,157,424,465,269,204,47,48,156,136,271,306],"class_list":["post-9966","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-biologics-naive","scientific_tags-clinical-remission","scientific_tags-clinical-reposnse","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-intensive","scientific_tags-observational","scientific_tags-predictive-factors","scientific_tags-prednisolone","scientific_tags-retrospective","scientific_tags-safety","scientific_tags-single-center","scientific_tags-study","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>P996 Clinical Efficacy and Predictive Factors for the Effectiveness of Granulocyte and Monocyte Adsorption Apheresis Therapy for Ulcerative Colitis\uff1aA Retrospective Observational Single Center Study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p996-clinical-efficacy-and-predictive-factors-for-the-effectiveness-of-granulocyte-and-monocyte-adsorption-apheresis-therapy-for-ulcerative-colitis\uff1aa-retrospective-observational-single-center\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"P996 Clinical Efficacy and Predictive Factors for the Effectiveness of Granulocyte and Monocyte Adsorption Apheresis Therapy for Ulcerative Colitis\uff1aA Retrospective Observational Single Center Study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"F Kenta, S Kensuke, T Shun, W Ryosuke, N Yusuke, Y Ren, S Kentaro, S Itsuki, O Hisashi, M Takuto Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i1807, doi.org=10.1093\/ecco-jcc\/jjad212.1126 Background Granulocyte and Monocyte Adsorption Apheresis (GMA) is one of the valuable non-immunosuppressive therapies in the treatment of ulcerative colitis (UC). 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