{"id":9953,"date":"2024-01-23T12:45:00","date_gmt":"2024-01-23T11:45:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9953"},"modified":"2024-03-27T12:51:01","modified_gmt":"2024-03-27T11:51:01","slug":"combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/","title":{"rendered":"Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">Iago Rodr\u00edguez-Lago\u00a01,\u00a0Fiorella Ca\u00f1ete\u00a02,\u00a0Elena Guerra-Del-R\u00edo\u00a03,\u00a0Claudia Herrera-deGuise\u00a04,\u00a0Eva Iglesias\u00a05,\u00a0Eduardo Leo\u00a06,\u00a0Yamile Zabana\u00a07,\u00a0Manuel Barreiro-de Acosta\u00a08,\u00a0Daniel Ginard\u00a09,\u00a0Jos\u00e9 Luis Cabriada\u00a010<br \/>\nGastroenterol Hepatol.\u00a02024 Jan 23:S0210-5705(24)00022-0.\u00a0doi: 10.1016\/j.gastrohep.2024.01.004.\u00a0Online ahead of print.<br \/>\n[Article in English, Spanish]<\/p>\n<p>Objective:\u00a0Granulocyte-monocyte apheresis (GMA) has shown to be safe and effective in treating ulcerative colitis (UC), also in combination with biologics. The objective of this study is to evaluate the efficacy and safety of combining GMA after primary non-response (PNR) or loss of response (LOR) to tofacitinib (TOFA) in patients with UC.<\/p>\n<p>Patients and methods:\u00a0Retrospective study including all patients with refractory UC who received GMA plus TOFA. Efficacy was assessed 1 and 6 months after finishing GMA by partial Mayo score, C-reactive protein (CRP) and fecal calprotectin (FC). Descriptive statistics and non-parametric tests were used in the statistical analysis.<\/p>\n<p>Results:\u00a0Twelve patients were included (median 46 years [IQR, 37-58]; 67% female; 67% E3). Patients were mostly receiving TOFA 10mg bid (75%), and 33% also concomitant steroids at baseline. Median partial Mayo score at baseline was 7 (IQR, 5-7), and it decreased to a median of 2 (IQR, 0-3) and 0 (IQR, 0-3) after 1 and 6 months (p=0.027 and 0.020, respectively), while no differences were found in CRP and FC. Clinical remission was achieved by 6 patients both at 1 (50%) and 6 months (67%). CF values<250mg\/kg were achieved by 2 and 4 patients at 1 and 6 months (data available in 5 and 7 patients, respectively). No patient required dose-escalation of TOFA, and one patient was able to de-escalate the drug. No patient required colectomy and all patients under steroids were able to stop them.\n\nConclusion:\u00a0The combination of GMA and TOFA can be effective in selected cases of UC after PNR or LOR to this drug<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Iago Rodr\u00edguez-Lago\u00a01,\u00a0Fiorella Ca\u00f1ete\u00a02,\u00a0Elena Guerra-Del-R\u00edo\u00a03,\u00a0Claudia Herrera-deGuise\u00a04,\u00a0Eva Iglesias\u00a05,\u00a0Eduardo Leo\u00a06,\u00a0Yamile Zabana\u00a07,\u00a0Manuel Barreiro-de Acosta\u00a08,\u00a0Daniel Ginard\u00a09,\u00a0Jos\u00e9 Luis Cabriada\u00a010 Gastroenterol Hepatol.\u00a02024 Jan 23:S0210-5705(24)00022-0.\u00a0doi: 10.1016\/j.gastrohep.2024.01.004.\u00a0Online ahead of print. [Article in English, Spanish] Objective:\u00a0Granulocyte-monocyte apheresis (GMA) has shown to be safe and effective in treating ulcerative colitis (UC), also in combination with biologics. The objective of this study is to evaluate the efficacy [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,303,157,424,435,434,100,789,748,53,48,156,354,271,450,306],"class_list":["post-9953","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-combination","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-lor","scientific_tags-loss-of-response","scientific_tags-multicenter","scientific_tags-pnr","scientific_tags-primary-non-response","scientific_tags-refractory-patients","scientific_tags-retrospective","scientific_tags-safety","scientific_tags-steroid-sparing","scientific_tags-study","scientific_tags-tofacitinib","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"http:\/\/Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - PubMed (nih.gov)\">http:\/\/Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - PubMed (nih.gov)<\/a>\r\n\r\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0210570524000220?via%3Dihub\">Combination of granulocyte\u2013monocyte apheresis and tofacitinib: Multicentre and retrospective study - ScienceDirect<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Iago Rodr\u00edguez-Lago\u00a01,\u00a0Fiorella Ca\u00f1ete\u00a02,\u00a0Elena Guerra-Del-R\u00edo\u00a03,\u00a0Claudia Herrera-deGuise\u00a04,\u00a0Eva Iglesias\u00a05,\u00a0Eduardo Leo\u00a06,\u00a0Yamile Zabana\u00a07,\u00a0Manuel Barreiro-de Acosta\u00a08,\u00a0Daniel Ginard\u00a09,\u00a0Jos\u00e9 Luis Cabriada\u00a010 Gastroenterol Hepatol.\u00a02024 Jan 23:S0210-5705(24)00022-0.\u00a0doi: 10.1016\/j.gastrohep.2024.01.004.\u00a0Online ahead of print. [Article in English, Spanish] Objective:\u00a0Granulocyte-monocyte apheresis (GMA) has shown to be safe and effective in treating ulcerative colitis (UC), also in combination with biologics. The objective of this study is to evaluate the efficacy [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T11:51:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/\",\"name\":\"Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-23T11:45:00+00:00\",\"dateModified\":\"2024-03-27T11:51:01+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combination-of-granulocyte-monocyte-apheresis-and-tofacitinib-multicentre-and-retrospective-study\/","og_locale":"es_ES","og_type":"article","og_title":"Combination of granulocyte-monocyte apheresis and tofacitinib: Multicentre and retrospective study - Adacyte","og_description":"Iago Rodr\u00edguez-Lago\u00a01,\u00a0Fiorella Ca\u00f1ete\u00a02,\u00a0Elena Guerra-Del-R\u00edo\u00a03,\u00a0Claudia Herrera-deGuise\u00a04,\u00a0Eva Iglesias\u00a05,\u00a0Eduardo Leo\u00a06,\u00a0Yamile Zabana\u00a07,\u00a0Manuel Barreiro-de Acosta\u00a08,\u00a0Daniel Ginard\u00a09,\u00a0Jos\u00e9 Luis Cabriada\u00a010 Gastroenterol Hepatol.\u00a02024 Jan 23:S0210-5705(24)00022-0.\u00a0doi: 10.1016\/j.gastrohep.2024.01.004.\u00a0Online ahead of print. 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