{"id":9051,"date":"2017-07-17T10:36:00","date_gmt":"2017-07-17T08:36:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=9051"},"modified":"2023-12-21T10:43:01","modified_gmt":"2023-12-21T09:43:01","slug":"advancements-in-inflammatory-bowel-disease-a-narrative-review-of-diagnostics-management-epidemiology-prevalence-patient-outcomes-quality-of-life-and-clinical-presentation","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/advancements-in-inflammatory-bowel-disease-a-narrative-review-of-diagnostics-management-epidemiology-prevalence-patient-outcomes-quality-of-life-and-clinical-presentation\/","title":{"rendered":"Advancements in Inflammatory Bowel Disease: A Narrative Review of Diagnostics, Management, Epidemiology, Prevalence, Patient Outcomes, Quality of Life, and Clinical Presentation"},"content":{"rendered":"
\n

Muhammad Ali Muzammil<\/a>\u00a01<\/a><\/sup>,\u00a0Fnu Fariha<\/a>\u00a02<\/a><\/sup>,\u00a0Tirath Patel<\/a>\u00a03<\/a><\/sup>,\u00a0Rohab Sohail<\/a>\u00a04<\/a><\/sup>,\u00a0Munesh Kumar<\/a>\u00a05<\/a><\/sup>,\u00a0Ejaz Khan<\/a>\u00a06<\/a><\/sup>,\u00a0Bushra Khanam<\/a>\u00a07<\/a><\/sup>,\u00a0Satesh Kumar<\/a>\u00a08<\/a><\/sup>,\u00a0Mahima Khatri<\/a>\u00a09<\/a><\/sup>,\u00a0Giustino Varrassi<\/a>\u00a010<\/a><\/sup>,\u00a0Prasanthi Vanga<\/a>\u00a011<\/a><\/sup>2023 Jun 28;15(6):e41120. doi: 10.7759\/cureus.41120.<\/p>\n<\/div>\n\n

\n

The functionality and aging mechanism of antibodies physisorbed onto cellulosic films
was investigated. Blood grouping antibodies immunoglobulin G (IgG) and immuno\u0002globulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regenerated
cellulose (RCF) films. Cellulose films and adsorbed IgG layers were characterized at the
air and liquid interface by X-ray and neutron reflectivity (NR), respectively. Cellulose film
208 \u00c5 thick (in air) swell to 386 \u00c5 once equilibrated in water. IgG adsorbs from solution
onto cellulose as a partial layer 62 \u00c5 thick. IgG and IgM antibodies were adsorbed onto
cellulose and cellulose acetate films, air dried, and aged at room temperature for periods
up to 20 days. Antibody functionality and surface hydrophobicity were measured every\u0002day with the size of red blood cell (RBC) agglutinates (using RBC specific to IgG\/IgM)
and the water droplet contact angle, respectively. The functionality of the aged IgG\/IgM
decreases faster if physisorbed on cellulose than on cellulose acetate and correlates to
surface hydrophobicity. IgG physisorbed on RCF or CAF age better and remain func\u0002tional longer than physisorbed IgM. We found a correlation between antibody stability
and hydrogen bond formation ability of the system, evaluated from antibody carbonyl
concentration and cellulosic surface hydroxyl concentration. Antibody physisorbs on cel\u0002lulose by weak dipole forces and hydrogen bonds. Strong hydrogen bonding contributes
to the physisorption of antibody on cellulose into a non-functional configuration in which
the molecule relaxes by rotation of hydophobic groups toward the air interface.<\/p>\n<\/div>\n\n

\n

Functionality of Immunoglobulin G and Immunoglobulin M Antibody Physisorbed on Cellulosic Films – PubMed (nih.gov)<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Muhammad Ali Muzammil\u00a01,\u00a0Fnu Fariha\u00a02,\u00a0Tirath Patel\u00a03,\u00a0Rohab Sohail\u00a04,\u00a0Munesh Kumar\u00a05,\u00a0Ejaz Khan\u00a06,\u00a0Bushra Khanam\u00a07,\u00a0Satesh Kumar\u00a08,\u00a0Mahima Khatri\u00a09,\u00a0Giustino Varrassi\u00a010,\u00a0Prasanthi Vanga\u00a0112023 Jun 28;15(6):e41120. doi: 10.7759\/cureus.41120. The functionality and aging mechanism of antibodies physisorbed onto cellulosic filmswas investigated. Blood grouping antibodies immunoglobulin G (IgG) and immuno\u0002globulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regeneratedcellulose (RCF) films. Cellulose films and adsorbed IgG […]<\/p>\n","protected":false},"template":"","scientific_tags":[103,762,398,56,426,761,173],"class_list":["post-9051","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-adsorption","scientific_tags-aging","scientific_tags-antibody","scientific_tags-cellulose","scientific_tags-ibd","scientific_tags-immunoglobulin","scientific_tags-moa"],"acf":[],"yoast_head":"\nAdvancements in Inflammatory Bowel Disease: A Narrative Review of Diagnostics, Management, Epidemiology, Prevalence, Patient Outcomes, Quality of Life, and Clinical Presentation - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/advancements-in-inflammatory-bowel-disease-a-narrative-review-of-diagnostics-management-epidemiology-prevalence-patient-outcomes-quality-of-life-and-clinical-presentation\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advancements in Inflammatory Bowel Disease: A Narrative Review of Diagnostics, Management, Epidemiology, Prevalence, Patient Outcomes, Quality of Life, and Clinical Presentation - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Muhammad Ali Muzammil\u00a01,\u00a0Fnu Fariha\u00a02,\u00a0Tirath Patel\u00a03,\u00a0Rohab Sohail\u00a04,\u00a0Munesh Kumar\u00a05,\u00a0Ejaz Khan\u00a06,\u00a0Bushra Khanam\u00a07,\u00a0Satesh Kumar\u00a08,\u00a0Mahima Khatri\u00a09,\u00a0Giustino Varrassi\u00a010,\u00a0Prasanthi Vanga\u00a0112023 Jun 28;15(6):e41120. doi: 10.7759\/cureus.41120. The functionality and aging mechanism of antibodies physisorbed onto cellulosic filmswas investigated. Blood grouping antibodies immunoglobulin G (IgG) and immuno\u0002globulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regeneratedcellulose (RCF) films. 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