{"id":8497,"date":"2013-01-17T08:41:00","date_gmt":"2013-01-17T08:41:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=8497"},"modified":"2022-10-26T08:47:13","modified_gmt":"2022-10-26T08:47:13","slug":"therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/","title":{"rendered":"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ikeda+S&amp;cauthor_id=23332516\">Shigaku Ikeda<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takahashi+H&amp;cauthor_id=23332516\">Hidetoshi Takahashi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Suga+Y&amp;cauthor_id=23332516\">Yasushi Suga<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Eto+H&amp;cauthor_id=23332516\">Hikaru Eto<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Etoh+T&amp;cauthor_id=23332516\">Takafumi Etoh<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Okuma+K&amp;cauthor_id=23332516\">Keiko Okuma<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takahashi+K&amp;cauthor_id=23332516\">Kazuo Takahashi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-7\">7<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kanbara+T&amp;cauthor_id=23332516\">Takeshi Kanbara<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-8\">8<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Seishima+M&amp;cauthor_id=23332516\">Mariko Seishima<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-9\">9<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Morita+A&amp;cauthor_id=23332516\">Akimichi Morita<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-10\">10<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Imai+Y&amp;cauthor_id=23332516\">Yasutomo Imai<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-11\">11<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kanekura+T&amp;cauthor_id=23332516\">Takuro Kanekura<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/#affiliation-12\">12<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>J Am Acad Dermatol 2013 Apr;68(4):609-617.\u00a0doi: 10.1016\/j.jaad.2012.09.037.\u00a0Epub 2013 Jan 17.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background:\u00a0<\/strong>Generalized pustular psoriasis (GPP) is a chronic autoimmune disease characterized by fever, erythema, and neutrophilic pustules over large areas of the skin. GPP does not respond well to pharmacologic intervention. <strong>Objective:\u00a0<\/strong>We sought to assess efficacy of selectively depleting the myeloid lineage leukocytes in patients with GPP. <strong>Methods:\u00a0<\/strong>Fifteen patients with persistent moderate to severe GPP despite conventional therapy were included. Eligible patients had more than 10% of their skin area covered by pustules. Treatment with oral etretinate, cyclosporine, methotrexate, prednisolone, and topical prednisolone\/vitamin D3 was continued if had been initiated well in advance of study entry. Five sessions of adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn (JIMRO Co Ltd, Takasaki, Japan) were administered (1 session\/wk over 5 weeks) to selectively deplete Fc\u03b3 receptor and complement receptor bearing leukocytes. Efficacy was assessed by measuring the skin areas covered by pustules at baseline and 2 weeks after the last GMA session. <strong>Results:\u00a0<\/strong>One patient did not complete the first GMA session. Based on the GPP severity scores relative to entry, the overall scores improved (n = 14, P = .0027), and the area of erythroderma (P = .0042), pustules (P = .0031), and edema (P = .0014) decreased. Likewise, Dermatology Life Quality Index improved (P = .0016), reflecting better daily function and quality of life. Twelve patients were judged as responders (85.7%), and 10 patients maintained the clinical response for 10 weeks after the last GMA session without any change in medication. <strong>Limitations:\u00a0<\/strong>This study was unblinded and without a placebo arm. <strong>Conclusion:\u00a0<\/strong>GMA in this clinical setting was safe and effective, suggested a major role for granulocytes\/monocytes in the immunopathogenesis of GPP.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/23332516\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Shigaku Ikeda\u00a01,\u00a0Hidetoshi Takahashi\u00a02,\u00a0Yasushi Suga\u00a03,\u00a0Hikaru Eto\u00a04,\u00a0Takafumi Etoh\u00a05,\u00a0Keiko Okuma\u00a06,\u00a0Kazuo Takahashi\u00a07,\u00a0Takeshi Kanbara\u00a08,\u00a0Mariko Seishima\u00a09,\u00a0Akimichi Morita\u00a010,\u00a0Yasutomo Imai\u00a011,\u00a0Takuro Kanekura\u00a012 J Am Acad Dermatol 2013 Apr;68(4):609-617.\u00a0doi: 10.1016\/j.jaad.2012.09.037.\u00a0Epub 2013 Jan 17. Background:\u00a0Generalized pustular psoriasis (GPP) is a chronic autoimmune disease characterized by fever, erythema, and neutrophilic pustules over large areas of the skin. GPP does not respond well to pharmacologic intervention. Objective:\u00a0We sought [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[588,157,424,267,312,667,386,107,666,445,67],"class_list":["post-8497","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-response","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-granulocytes","scientific_tags-immunology","scientific_tags-immunopathogenesis","scientific_tags-leukocyte","scientific_tags-monocyte","scientific_tags-myeloid","scientific_tags-neutrophil","scientific_tags-pustular-psoriasis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Shigaku Ikeda\u00a01,\u00a0Hidetoshi Takahashi\u00a02,\u00a0Yasushi Suga\u00a03,\u00a0Hikaru Eto\u00a04,\u00a0Takafumi Etoh\u00a05,\u00a0Keiko Okuma\u00a06,\u00a0Kazuo Takahashi\u00a07,\u00a0Takeshi Kanbara\u00a08,\u00a0Mariko Seishima\u00a09,\u00a0Akimichi Morita\u00a010,\u00a0Yasutomo Imai\u00a011,\u00a0Takuro Kanekura\u00a012 J Am Acad Dermatol 2013 Apr;68(4):609-617.\u00a0doi: 10.1016\/j.jaad.2012.09.037.\u00a0Epub 2013 Jan 17. Background:\u00a0Generalized pustular psoriasis (GPP) is a chronic autoimmune disease characterized by fever, erythema, and neutrophilic pustules over large areas of the skin. GPP does not respond well to pharmacologic intervention. Objective:\u00a0We sought [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-26T08:47:13+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/\",\"name\":\"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2013-01-17T08:41:00+00:00\",\"dateModified\":\"2022-10-26T08:47:13+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/therapeutic-depletion-of-myeloid-lineage-leukocytes-in-patients-with-generalized-pustular-psoriasis-indicates-a-major-role-for-neutrophils-in-the-immunopathogenesis-of-psoriasis\/","og_locale":"es_ES","og_type":"article","og_title":"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis - Adacyte","og_description":"Shigaku Ikeda\u00a01,\u00a0Hidetoshi Takahashi\u00a02,\u00a0Yasushi Suga\u00a03,\u00a0Hikaru Eto\u00a04,\u00a0Takafumi Etoh\u00a05,\u00a0Keiko Okuma\u00a06,\u00a0Kazuo Takahashi\u00a07,\u00a0Takeshi Kanbara\u00a08,\u00a0Mariko Seishima\u00a09,\u00a0Akimichi Morita\u00a010,\u00a0Yasutomo Imai\u00a011,\u00a0Takuro Kanekura\u00a012 J Am Acad Dermatol 2013 Apr;68(4):609-617.\u00a0doi: 10.1016\/j.jaad.2012.09.037.\u00a0Epub 2013 Jan 17. 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