{"id":7964,"date":"2005-01-15T14:04:00","date_gmt":"2005-01-15T14:04:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=7964"},"modified":"2022-04-12T14:12:36","modified_gmt":"2022-04-12T14:12:36","slug":"granulocyte-and-monocyte-adsorption-apheresis-in-korean-conventional-treatment-refractory-patients-with-active-ulcerative-colitis-a-prospective-open-label-multicenter-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorption-apheresis-in-korean-conventional-treatment-refractory-patients-with-active-ulcerative-colitis-a-prospective-open-label-multicenter-study\/","title":{"rendered":"[Granulocyte and monocyte adsorption apheresis in Korean conventional treatment-refractory patients with active ulcerative colitis: a prospective open-label multicenter study]"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>[Article in Korean ]<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kim+HJ&amp;cauthor_id=15665566\">Hyo Jong Kim<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15665566\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kim+JS&amp;cauthor_id=15665566\">Joo Sung Kim<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Han+DS&amp;cauthor_id=15665566\">Dong Soo Han<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yang+SK&amp;cauthor_id=15665566\">Suk-Kyun Yang<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hahm+KB&amp;cauthor_id=15665566\">Ki Baik Hahm<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lee+WI&amp;cauthor_id=15665566\">Woo In Lee<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kwon+SW&amp;cauthor_id=15665566\">Seog-Woon Kwon<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Choi+JH&amp;cauthor_id=15665566\">Jai Hyun Choi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kim+WH&amp;cauthor_id=15665566\">Won Ho Kim<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Choi+KY&amp;cauthor_id=15665566\">Kyu Yong Choi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Song+IS&amp;cauthor_id=15665566\">In Sung Song<\/a> Korean J Gastroenterol <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Korean+J+Gastroenterol%22%5Bjour%5D\"><\/a>\u00a02005 Jan;45(1):34-44. PMID:\u00a0<strong style=\"color: initial;\">15665566<\/strong><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background\/aims:\u00a0<\/strong>In chronic inflammatory conditions such as ulcerative colitis (UC), the migration of granulocytes and monocytes\/macrophages from the circulation into the colonic mucosa is especially important in maintaining inflammation. The aim of this trial was to assess safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with moderate-to-severe UC refractory to conventional drug therapies. <strong>Methods:\u00a0<\/strong>Twenty-seven patients with moderate (55.6%) to severe (44.4%) active UC refractory to conventional drug therapies who had no changes in their conventional therapy regimen in the past two weeks before the recruitment were enrolled in an open-label trial. Concomitant medications were allowed, and steroids were tapered down according to the clinical activity during the course. We used an adsorptive type extracorporeal column (Adacolumn; JIMRO, Takasaki, Japan), which selectively adsorb granulocytes and monocytes. Patients took five apheresis sessions, each with 60 minutes duration for 5 consecutive weeks. The primary efficacy variables were clinical disease activity, short inflammatory bowel disease questionnaire (SIBDQ), C-reactive protein (CRP), and endoscopic scores. These variables were scored at regular intervals, and analyzed at week 7 on an intention-to-treat (ITT) principles. <strong>Results:\u00a0<\/strong>At 7 weeks, 70.4% of patients showed overall improvement. Clinical disease activity (p &lt; 0.0001), endoscopic score (p &lt; 0.001), and the quality of life as assessed by SIBDQ (p &lt; 0.0001) were significantly improved after the therapy. In 56.3% of concomitant steroid users, tapering down or discontinuation of steroids was possible. Treatment was well tolerated, and no severe adverse events were observed. <strong>Conclusions:\u00a0<\/strong>Adacolumn was very efficacious in patients with moderate-to-severe active UC refractory to conventional drug therapy, but further assessment is needed.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15665566\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15665566\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[Article in Korean ]Hyo Jong Kim\u00a01,\u00a0Joo Sung Kim,\u00a0Dong Soo Han,\u00a0Suk-Kyun Yang,\u00a0Ki Baik Hahm,\u00a0Woo In Lee,\u00a0Seog-Woon Kwon,\u00a0Jai Hyun Choi,\u00a0Won Ho Kim,\u00a0Kyu Yong Choi,\u00a0In Sung Song Korean J Gastroenterol \u00a02005 Jan;45(1):34-44. PMID:\u00a015665566 Background\/aims:\u00a0In chronic inflammatory conditions such as ulcerative colitis (UC), the migration of granulocytes and monocytes\/macrophages from the circulation into the colonic mucosa is especially important [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,397,424,627,100,96,97,75,53,523,306],"class_list":["post-7964","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-endoscopic-remission","scientific_tags-gma","scientific_tags-moderate-to-severe","scientific_tags-multicenter","scientific_tags-open-label","scientific_tags-prospective","scientific_tags-qol","scientific_tags-refractory-patients","scientific_tags-steroid-tapering","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>[Granulocyte and monocyte adsorption apheresis in Korean conventional treatment-refractory patients with active ulcerative colitis: a prospective open-label multicenter study] - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorption-apheresis-in-korean-conventional-treatment-refractory-patients-with-active-ulcerative-colitis-a-prospective-open-label-multicenter-study\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[Granulocyte and monocyte adsorption apheresis in Korean conventional treatment-refractory patients with active ulcerative colitis: a prospective open-label multicenter study] - Adacyte\" \/>\n<meta property=\"og:description\" content=\"[Article in Korean ]Hyo Jong Kim\u00a01,\u00a0Joo Sung Kim,\u00a0Dong Soo Han,\u00a0Suk-Kyun Yang,\u00a0Ki Baik Hahm,\u00a0Woo In Lee,\u00a0Seog-Woon Kwon,\u00a0Jai Hyun Choi,\u00a0Won Ho Kim,\u00a0Kyu Yong Choi,\u00a0In Sung Song Korean J Gastroenterol \u00a02005 Jan;45(1):34-44. 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