{"id":7138,"date":"2009-09-01T11:43:00","date_gmt":"2009-09-01T11:43:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=7138"},"modified":"2022-04-01T11:53:02","modified_gmt":"2022-04-01T11:53:02","slug":"clinical-endoscopic-and-histological-remission-in-paediatric-chronically-active-ulcerative-colitis-after-prolonged-treatment-with-selective-granulocyte-monocyte-adsorptive-apheresis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/clinical-endoscopic-and-histological-remission-in-paediatric-chronically-active-ulcerative-colitis-after-prolonged-treatment-with-selective-granulocyte-monocyte-adsorptive-apheresis\/","title":{"rendered":"Clinical, endoscopic and histological remission in paediatric chronically active ulcerative colitis after prolonged treatment with selective granulocyte\u2013monocyte adsorptive apheresis\u00a0"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"javascript:;\">Javier Martin-Carpi Mart\u00edn-Carpi<\/a>,\u00a0<a href=\"javascript:;\">Vicente Varea<\/a> <em>Journal of Crohn&#8217;s and Colitis<\/em>, Volume 3, Issue 3, September 2009, Pages 216\u2013217,\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.crohns.2009.03.003\">https:\/\/doi.org\/10.1016\/j.crohns.2009.03.003<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Treatment of paediatric ulcerative colitis (UC) unresponsive to conventional treatment<\/strong> constitutes a challenge. The finding of new secure, steroid-sparing and long acting treatments for these cases are mandatory. We report our experience with a <strong>long-term therapeutic strategy with Adacolumn in a chronically active paediatric UC patient<\/strong> (9 year-old boy) with the aim of achieving <strong>stabilization and ameliorating symptoms<\/strong>, permitting a successful switch to AZA monotherapy. These two aspects have been achieved without reappearance of rectal bleeding after oral mesalamine suppression. But the most interesting and promising finding is the confirmation of <strong>GMA apheresis effect on mucosal healing after prolonged treatment: maintenance treatment with Adacolumn has been effective in achieving a complete endoscopic and histological remission<\/strong>.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>This case shows the utility of prolonged Adacolumn treatment in chronically active UC patients.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/academic.oup.com\/ecco-jcc\/article\/3\/3\/216\/384285\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/academic.oup.com\/ecco-jcc\/article\/3\/3\/216\/384285<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Javier Martin-Carpi Mart\u00edn-Carpi,\u00a0Vicente Varea Journal of Crohn&#8217;s and Colitis, Volume 3, Issue 3, September 2009, Pages 216\u2013217,\u00a0https:\/\/doi.org\/10.1016\/j.crohns.2009.03.003 Treatment of paediatric ulcerative colitis (UC) unresponsive to conventional treatment constitutes a challenge. The finding of new secure, steroid-sparing and long acting treatments for these cases are mandatory. We report our experience with a long-term therapeutic strategy with [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[596,147,598,599,424,600,91,308,597,174,156,55,135,306],"class_list":["post-7138","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-chronic-active","scientific_tags-clinical-remission","scientific_tags-complete-endoscopic-remission","scientific_tags-complete-histologic-remission","scientific_tags-gma","scientific_tags-long-term-remission","scientific_tags-maintenance","scientific_tags-mucosal-healing","scientific_tags-paediatric","scientific_tags-pilot-study","scientific_tags-safety","scientific_tags-steroid-dependent","scientific_tags-steroid-refractory","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Clinical, endoscopic and histological remission in paediatric chronically active ulcerative colitis after prolonged treatment with selective granulocyte\u2013monocyte adsorptive apheresis\u00a0 - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/clinical-endoscopic-and-histological-remission-in-paediatric-chronically-active-ulcerative-colitis-after-prolonged-treatment-with-selective-granulocyte-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical, endoscopic and histological remission in paediatric chronically active ulcerative colitis after prolonged treatment with selective granulocyte\u2013monocyte adsorptive apheresis\u00a0 - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Javier Martin-Carpi Mart\u00edn-Carpi,\u00a0Vicente Varea Journal of Crohn&#8217;s and Colitis, Volume 3, Issue 3, September 2009, Pages 216\u2013217,\u00a0https:\/\/doi.org\/10.1016\/j.crohns.2009.03.003 Treatment of paediatric ulcerative colitis (UC) unresponsive to conventional treatment constitutes a challenge. 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