{"id":7020,"date":"2005-04-24T10:07:00","date_gmt":"2005-04-24T10:07:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=7020"},"modified":"2022-03-24T10:30:12","modified_gmt":"2022-03-24T10:30:12","slug":"suppression-of-inflammatory-cytokine-secretion-by-granulocyte-monocyte-adsorptive-apheresis-in-active-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/suppression-of-inflammatory-cytokine-secretion-by-granulocyte-monocyte-adsorptive-apheresis-in-active-ulcerative-colitis\/","title":{"rendered":"Suppression of Inflammatory Cytokine Secretion by Granulocyte\/Monocyte Adsorptive Apheresis in Active Ulcerative Colitis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Andoh%2C+Akira\">Akira Andoh<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Tsujikawa%2C+Tomoyuki\">Tomoyuki Tsujikawa<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Inatomi%2C+Osamu\">Osamu Inatomi<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Deguchi%2C+Yasuyuki\">Yasuyuki Deguchi<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Hata%2C+Kazunori\">Kazunori Hata<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Kitoh%2C+Katsuyuki\">Katsuyuki Kitoh<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Sasaki%2C+Masaya\">Masaya Sasaki<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Mitsuyama%2C+Keiichi\">Keiichi Mitsuyama<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/action\/doSearch?ContribAuthorRaw=Fujiyama%2C+Yoshihide\">Yoshihide Fujiyama<\/a> Therap Apher Dial(2005) <a href=\"https:\/\/onlinelibrary.wiley.com\/toc\/17449987\/2005\/9\/2\">9, 2<\/a>;&nbsp;23-127,&nbsp;<a href=\"https:\/\/doi.org\/10.1111\/j.1774-9987.2005.00229.x\">https:\/\/doi.org\/10.1111\/j.1774-9987.2005.00229.x<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>To elucidate the molecular mechanisms involved in the therapeutic effects of granulocyte\/monocyte adsorption apheresis, changes were investigated in the cytokine responses of peripheral blood mononuclear cells (PBMC) before and after granulocyte\/monocyte adsorptive apheresis in ulcerative colitis (UC) patients. Four patients with active UC were enrolled. All patients responded to granulocyte\/monocyte adsorptive apheresis. A total of 20 sessions of four patients were analyzed. Peripheral blood mononuclear cells were isolated from peripheral venous blood within 5min before and after each session of granulocyte\/monocyte adsorptive apheresis. The cells were stimulated with interleukin (IL)-1\u03b2 and tumor necrosis factor (TNF)-\u03b1 for 24h, and the secreted IL-8 and IL-6 levels were determined by enzyme-linked immunosorbent assay (ELISA). IL-1\u03b2-induced IL-8 and IL-6 secretion was significantly decreased after granulocyte\/monocyte adsorptive apheresis. TNF-\u03b1-induced IL-8 secretion was also significantly decreased after apheresis, but there was no significant difference in TNF-\u03b1-induced IL-6 secretion (<em>P<\/em>\u2003=\u20030.052). In conclusion, granulocyte\/monocyte adsorptive apheresis down-regulates the IL-1\u03b2- and TNF-\u03b1-induced inflammatory responses in PBMC. The induction of hyporesponsiveness to pro-inflammatory cytokines may be an important factor mediating the clinical effects of granulocyte\/macrophage adsorptive apheresis in UC patients.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15828923\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15828923\/<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1774-9987.2005.00229.x\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1774-9987.2005.00229.x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Akira Andoh,Tomoyuki Tsujikawa,Osamu Inatomi,Yasuyuki Deguchi,Kazunori Hata,Katsuyuki Kitoh,Masaya Sasaki,Keiichi Mitsuyama,Yoshihide Fujiyama Therap Apher Dial(2005) 9, 2;&nbsp;23-127,&nbsp;https:\/\/doi.org\/10.1111\/j.1774-9987.2005.00229.x To elucidate the molecular mechanisms involved in the therapeutic effects of granulocyte\/monocyte adsorption apheresis, changes were investigated in the cytokine responses of peripheral blood mononuclear cells (PBMC) before and after granulocyte\/monocyte adsorptive apheresis in ulcerative colitis (UC) patients. Four patients [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[79,424,576,575,268,84,173,574,573,183,306],"class_list":["post-7020","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cytokines","scientific_tags-gma","scientific_tags-hyporesponsiveness","scientific_tags-il-1b","scientific_tags-il-8","scientific_tags-il6","scientific_tags-moa","scientific_tags-pbmc","scientific_tags-peripheral-blood-mononuclear-cells","scientific_tags-tnf-","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Suppression of Inflammatory Cytokine Secretion by Granulocyte\/Monocyte Adsorptive Apheresis in Active Ulcerative Colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/suppression-of-inflammatory-cytokine-secretion-by-granulocyte-monocyte-adsorptive-apheresis-in-active-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Suppression of Inflammatory Cytokine Secretion by Granulocyte\/Monocyte Adsorptive Apheresis in Active Ulcerative Colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Akira Andoh,Tomoyuki Tsujikawa,Osamu Inatomi,Yasuyuki Deguchi,Kazunori Hata,Katsuyuki Kitoh,Masaya Sasaki,Keiichi Mitsuyama,Yoshihide Fujiyama Therap Apher Dial(2005) 9, 2;&nbsp;23-127,&nbsp;https:\/\/doi.org\/10.1111\/j.1774-9987.2005.00229.x To elucidate the molecular mechanisms involved in the therapeutic effects of granulocyte\/monocyte adsorption apheresis, changes were investigated in the cytokine responses of peripheral blood mononuclear cells (PBMC) before and after granulocyte\/monocyte adsorptive apheresis in ulcerative colitis (UC) patients. 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