{"id":6812,"date":"2004-12-01T12:34:00","date_gmt":"2004-12-01T12:34:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6812"},"modified":"2022-02-08T12:41:04","modified_gmt":"2022-02-08T12:41:04","slug":"granulocyteaphaeresis-in-steroid-dependent-inflammatory-bowel-disease-a-prospective-open-pilot-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyteaphaeresis-in-steroid-dependent-inflammatory-bowel-disease-a-prospective-open-pilot-study\/","title":{"rendered":"Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dom%C3%A8nech+E&amp;cauthor_id=15606397\">E Dom\u00e8nech<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15606397\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hinojosa+J&amp;cauthor_id=15606397\">J Hinojosa<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Esteve-Comas+M&amp;cauthor_id=15606397\">M Esteve-Comas<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Gomoll%C3%B3n+F&amp;cauthor_id=15606397\">F Gomoll\u00f3n<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Herrera+JM&amp;cauthor_id=15606397\">J M Herrera<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bastida+G&amp;cauthor_id=15606397\">G Bastida<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Obrador+A&amp;cauthor_id=15606397\">A Obrador<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ruiz+R&amp;cauthor_id=15606397\">R Ruiz<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Saro+C&amp;cauthor_id=15606397\">C Saro<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Gassull+MA&amp;cauthor_id=15606397\">M A Gassull<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Spanish+Group+for+the+Study+of+Crohn%27s+Disease+and+Ulcerative+Colitis+%28GETECCU%29%5BCorporate+Author%5D\">Spanish Group for the Study of Crohn&#8217;s Disease and Ulcerative Colitis (GETECCU)<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Aliment Pharmacol Ther. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Aliment+Pharmacol+Ther%22%5Bjour%5D\"><\/a>2004 Dec;20(11-12):1347-52.\u00a0doi: 10.1111\/j.1365-2036.2004.02288.x.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background:\u00a0<\/strong>Uncontrolled studies suggest that granulocyteaphaeresis might be useful in the management of active ulcerative colitis. <strong>Aim:\u00a0<\/strong>To assess the efficacy of granulocyteaphaeresis treatment in active steroid-dependent inflammatory bowel disease. <strong>Methods:\u00a0<\/strong>We conducted a multicentre, prospective, open, pilot study in patients with steroid-dependent inflammatory bowel disease. All patients were started on 60 mg\/day of prednisone; after 1 week, a five-session programme of granulocyteaphaeresis (once per week) was started. The steroid dose was tapered weekly if there was clinical improvement. Remission was defined as an inactive clinical activity index together with complete withdrawal of steroids at week 6. The patients were followed up for at least 6 months or until disease relapse. <strong>Results:\u00a0<\/strong>Twenty-six patients (14 ulcerative colitis, 12 Crohn&#8217;s disease) were included. More than a half had been previously treated with immunomodulators. Remission was achieved in 62 and 70% of ulcerative colitis and Crohn&#8217;s disease, respectively. During a median follow-up of 12.6 months, six of eight ulcerative colitis patients maintained their clinical remission; however, only one Crohn&#8217;s disease patient remained in remission after the first 6 months of follow-up. <strong>Conclusions:\u00a0<\/strong>Granulocyteaphaeresis is a safe treatment option in inflammatory bowel disease. A five-session programme of granulocyteaphaeresis seems to be efficient in the treatment of steroid-dependent ulcerative colitis, but not in Crohn&#8217;s disease.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15606397\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15606397\/<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/j.1365-2036.2004.02288.x\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/j.1365-2036.2004.02288.x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>E Dom\u00e8nech\u00a01,\u00a0J Hinojosa,\u00a0M Esteve-Comas,\u00a0F Gomoll\u00f3n,\u00a0J M Herrera,\u00a0G Bastida,\u00a0A Obrador,\u00a0R Ruiz,\u00a0C Saro,\u00a0M A Gassull,\u00a0Spanish Group for the Study of Crohn&#8217;s Disease and Ulcerative Colitis (GETECCU) Aliment Pharmacol Ther. 2004 Dec;20(11-12):1347-52.\u00a0doi: 10.1111\/j.1365-2036.2004.02288.x. Background:\u00a0Uncontrolled studies suggest that granulocyteaphaeresis might be useful in the management of active ulcerative colitis. Aim:\u00a0To assess the efficacy of granulocyteaphaeresis treatment in active steroid-dependent [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,330,159,424,426,96,174,97,55,334,306],"class_list":["post-6812","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-clinical-trial","scientific_tags-crohns-disease","scientific_tags-gma","scientific_tags-ibd","scientific_tags-open-label","scientific_tags-pilot-study","scientific_tags-prospective","scientific_tags-steroid-dependent","scientific_tags-steroid-free-remission","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyteaphaeresis-in-steroid-dependent-inflammatory-bowel-disease-a-prospective-open-pilot-study\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"E Dom\u00e8nech\u00a01,\u00a0J Hinojosa,\u00a0M Esteve-Comas,\u00a0F Gomoll\u00f3n,\u00a0J M Herrera,\u00a0G Bastida,\u00a0A Obrador,\u00a0R Ruiz,\u00a0C Saro,\u00a0M A Gassull,\u00a0Spanish Group for the Study of Crohn&#8217;s Disease and Ulcerative Colitis (GETECCU) Aliment Pharmacol Ther. 2004 Dec;20(11-12):1347-52.\u00a0doi: 10.1111\/j.1365-2036.2004.02288.x. Background:\u00a0Uncontrolled studies suggest that granulocyteaphaeresis might be useful in the management of active ulcerative colitis. 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