{"id":6623,"date":"1998-01-28T11:58:00","date_gmt":"1998-01-28T11:58:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6623"},"modified":"2022-01-28T12:07:35","modified_gmt":"2022-01-28T12:07:35","slug":"granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/","title":{"rendered":"Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Nagashima+M&amp;cauthor_id=9833252\">M Nagashima<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9833252\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Yoshino+S&amp;cauthor_id=9833252\">S Yoshino<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Tanaka+H&amp;cauthor_id=9833252\">H Tanaka<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Yoshida+N&amp;cauthor_id=9833252\">N Yoshida<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Kashiwagi+N&amp;cauthor_id=9833252\">N Kashiwagi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=Saniabadi+AR&amp;cauthor_id=9833252\">A R Saniabadi<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Rheumatol Int<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=pubdate&amp;term=%22Rheumatol+Int%22%5Bjour%5D\"><\/a>.\u00a01998;18(3):113-8.\u00a0doi: 10.1007\/s002960050068.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 column) is an extracorporeal type device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. Patients received apheresis of 1 hr duration twice per week, 8 times over a period of 4 weeks. To prepare CD15+CD16- cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16- cells in patients with high bone marrow CD15+CD16- cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P &lt; 0.001), tender joint count (P &lt; 0.001) and duration of morning stiffness (P &lt; 0.005). The results suggest that granulocytes and monocytes\/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9833252\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/9833252\/<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs002960050068\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007%2Fs002960050068<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>M Nagashima\u00a01,\u00a0S Yoshino,\u00a0H Tanaka,\u00a0N Yoshida,\u00a0N Kashiwagi,\u00a0A R Saniabadi Rheumatol Int.\u00a01998;18(3):113-8.\u00a0doi: 10.1007\/s002960050068. To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[424,105,312,107,174,453,336,274],"class_list":["post-6623","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-gma","scientific_tags-granulocyte","scientific_tags-immunology","scientific_tags-monocyte","scientific_tags-pilot-study","scientific_tags-rheumatoid-arthritis","scientific_tags-rheumatology","scientific_tags-symptoms-efficay"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"M Nagashima\u00a01,\u00a0S Yoshino,\u00a0H Tanaka,\u00a0N Yoshida,\u00a0N Kashiwagi,\u00a0A R Saniabadi Rheumatol Int.\u00a01998;18(3):113-8.\u00a0doi: 10.1007\/s002960050068. To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-28T12:07:35+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/\",\"name\":\"Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"1998-01-28T11:58:00+00:00\",\"dateModified\":\"2022-01-28T12:07:35+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-suppresses-symptoms-of-rheumatoid-arthritis-a-pilot-study\/","og_locale":"es_ES","og_type":"article","og_title":"Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study - Adacyte","og_description":"M Nagashima\u00a01,\u00a0S Yoshino,\u00a0H Tanaka,\u00a0N Yoshida,\u00a0N Kashiwagi,\u00a0A R Saniabadi Rheumatol Int.\u00a01998;18(3):113-8.\u00a0doi: 10.1007\/s002960050068. To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. 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