{"id":6615,"date":"2003-05-19T15:23:00","date_gmt":"2003-05-19T15:23:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6615"},"modified":"2022-01-27T15:29:29","modified_gmt":"2022-01-27T15:29:29","slug":"in-vivo-modulation-of-leukocyte-trafficking-receptor-following-therapeutic-purging-of-myeloid-cells-implications-for-treatment-of-hiv-infection-and-other-immune-disorders","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/in-vivo-modulation-of-leukocyte-trafficking-receptor-following-therapeutic-purging-of-myeloid-cells-implications-for-treatment-of-hiv-infection-and-other-immune-disorders\/","title":{"rendered":"In vivo modulation of leukocyte trafficking receptor following therapeutic purging of myeloid cells: implications for treatment of HIV infection and other immune disorders"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Priscilla Biswas <a href=\"https:\/\/independent.academia.edu\/BarbaraMantelli?swp=tc-au-18529622\">Barbara Mantelli<\/a><a href=\"https:\/\/independent.academia.edu\/AlbertoBeretta?swp=tc-au-18529622\"> Alberto Beretta<\/a> Clinical\u00a0Immunology\u00a0109\u00a0(2003)\u00a0355\u2013358\u00a0DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.clim.2003.07.001\">10.1016\/j.clim.2003.07.001<\/a>\u00a0<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Therapeutic purging of myeloid cells (monocytes and granulocytes) (MYP) has been proposed as a treatment of severe in\ufb02ammatoryconditions like ulcerative colitis and rheumatoid arthritis. Although direct purging of in\ufb02ammatory cells contributes to its ef\ufb01cacy, the precise mechanism of action is still unclear. We have tested MYP in a pilot study on 12 patients with chronic HIV infection, of whom 6 underwent MYP. Three\/6 MYP patients and none of the controls displayed a strong and long-lasting decrease of cells expressing CXCR3,a major chemokine receptor responsible for traf\ufb01cking of in\ufb02ammatory cells. In these three patients, the number of circulating CD4 T cells increased during treatment. The data provide a rational for the use of MYP as a therapeutic tool acting via the modulation of immune cell traf\ufb01cking<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/europepmc.org\/article\/med\/14697751\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/europepmc.org\/article\/med\/14697751<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Priscilla Biswas Barbara Mantelli Alberto Beretta Clinical\u00a0Immunology\u00a0109\u00a0(2003)\u00a0355\u2013358\u00a0DOI:\u00a010.1016\/j.clim.2003.07.001\u00a0 Therapeutic purging of myeloid cells (monocytes and granulocytes) (MYP) has been proposed as a treatment of severe in\ufb02ammatoryconditions like ulcerative colitis and rheumatoid arthritis. Although direct purging of in\ufb02ammatory cells contributes to its ef\ufb01cacy, the precise mechanism of action is still unclear. We have tested MYP in a [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[456,178,515,105,513,386,512,107,366],"class_list":["post-6615","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-autoimmune-disease","scientific_tags-cd4","scientific_tags-cxcr3","scientific_tags-granulocyte","scientific_tags-hiv","scientific_tags-leukocyte","scientific_tags-leukocyte-infiltration","scientific_tags-monocyte","scientific_tags-neutrophil-infiltration"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>In vivo modulation of leukocyte trafficking receptor following therapeutic purging of myeloid cells: implications for treatment of HIV infection and other immune disorders - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/in-vivo-modulation-of-leukocyte-trafficking-receptor-following-therapeutic-purging-of-myeloid-cells-implications-for-treatment-of-hiv-infection-and-other-immune-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In vivo modulation of leukocyte trafficking receptor following therapeutic purging of myeloid cells: implications for treatment of HIV infection and other immune disorders - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Priscilla Biswas Barbara Mantelli Alberto Beretta Clinical\u00a0Immunology\u00a0109\u00a0(2003)\u00a0355\u2013358\u00a0DOI:\u00a010.1016\/j.clim.2003.07.001\u00a0 Therapeutic purging of myeloid cells (monocytes and granulocytes) (MYP) has been proposed as a treatment of severe in\ufb02ammatoryconditions like ulcerative colitis and rheumatoid arthritis. 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