{"id":6612,"date":"2006-09-27T15:07:00","date_gmt":"2006-09-27T15:07:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6612"},"modified":"2022-01-27T15:12:53","modified_gmt":"2022-01-27T15:12:53","slug":"a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/","title":{"rendered":"A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Suzuki+Y&amp;cauthor_id=17004123\">Yasuo Suzuki<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17004123\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yoshimura+N&amp;cauthor_id=17004123\">Naoki Yoshimura<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fukuda+K&amp;cauthor_id=17004123\">Katsuyuki Fukuda<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Shirai+K&amp;cauthor_id=17004123\">Koji Shirai<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Saito+Y&amp;cauthor_id=17004123\">Yasushi Saito<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Saniabadi+AR&amp;cauthor_id=17004123\">Abbi R Saniabadi<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Dig Dis Sci. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Dig+Dis+Sci%22%5Bjour%5D\"><\/a>\u00a02006 Nov;51(11):2031-8.\u00a0doi: 10.1007\/s10620-006-9199-9.\u00a0Epub 2006 Sep 27.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Recently, selective granulocytapheresis (Adacolumn) has appeared as a new treatment for patients with inflammatory bowel disease. This study sought to determine predictors of response to this new nonpharmacologic mode of therapy by retrospectively evaluating 28 patients who received granulocytapheresis after experiencing active ulcerative colitis (UC). Between April 2000 and March 2004, 28 consecutive patients received granulocytapheresis for active UC with the Adacolumn, which is filled with cellulose acetate beads as the column leukocytapheresis carriers; the carriers adsorb granulocytes, monocytes\/macrophages, and a small fraction of lymphocytes (FcgammaR and complement receptors bearing leukocytes). Each patient could receive up to 10 Adacolumn sessions, at 2 sessions per week. In 2004, clinical response was retrospectively evaluated. Seven days after the last Adacolumn session, 20 of 28 patients had remission (colitis activity index [CAI] &lt; or =4) including all 8 patients who had their first UC episode. The mean duration of UC in the 8 first episode cases was 3.4 months compared with 40.2 months for all 28 patients and 65.4 months for the 8 nonresponders. The response to Adacolumn was independent of basal CAI. The 8 nonresponders were given conventional medication (CM) or cyclosporine (CsA) if the former failed. Two responded to CM, 3 to CsA, and 3 underwent colectomy. First UC episode and short disease duration appear good predictors of response to granulocytapheresis. Selective granulocytapheresis might be an effective first-line treatment.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17004123\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17004123\/<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs10620-006-9199-9\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007%2Fs10620-006-9199-9<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Yasuo Suzuki\u00a01,\u00a0Naoki Yoshimura,\u00a0Katsuyuki Fukuda,\u00a0Koji Shirai,\u00a0Yasushi Saito,\u00a0Abbi R Saniabadi Dig Dis Sci. \u00a02006 Nov;51(11):2031-8.\u00a0doi: 10.1007\/s10620-006-9199-9.\u00a0Epub 2006 Sep 27. Recently, selective granulocytapheresis (Adacolumn) has appeared as a new treatment for patients with inflammatory bowel disease. This study sought to determine predictors of response to this new nonpharmacologic mode of therapy by retrospectively evaluating 28 patients who received [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,205,510,424,465,224,48,306],"class_list":["post-6612","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-early-treatment","scientific_tags-first-line-treatment","scientific_tags-gma","scientific_tags-intensive","scientific_tags-predictors-of-response","scientific_tags-retrospective","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yasuo Suzuki\u00a01,\u00a0Naoki Yoshimura,\u00a0Katsuyuki Fukuda,\u00a0Koji Shirai,\u00a0Yasushi Saito,\u00a0Abbi R Saniabadi Dig Dis Sci. \u00a02006 Nov;51(11):2031-8.\u00a0doi: 10.1007\/s10620-006-9199-9.\u00a0Epub 2006 Sep 27. Recently, selective granulocytapheresis (Adacolumn) has appeared as a new treatment for patients with inflammatory bowel disease. This study sought to determine predictors of response to this new nonpharmacologic mode of therapy by retrospectively evaluating 28 patients who received [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-27T15:12:53+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/\",\"name\":\"A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2006-09-27T15:07:00+00:00\",\"dateModified\":\"2022-01-27T15:12:53+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-search-for-predictors-of-clinical-response-to-selective-granulocyte-and-monocyte-apheresis-in-patients-with-ulcerative-colitis\/","og_locale":"es_ES","og_type":"article","og_title":"A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis - Adacyte","og_description":"Yasuo Suzuki\u00a01,\u00a0Naoki Yoshimura,\u00a0Katsuyuki Fukuda,\u00a0Koji Shirai,\u00a0Yasushi Saito,\u00a0Abbi R Saniabadi Dig Dis Sci. \u00a02006 Nov;51(11):2031-8.\u00a0doi: 10.1007\/s10620-006-9199-9.\u00a0Epub 2006 Sep 27. 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