{"id":6555,"date":"2009-11-26T14:50:00","date_gmt":"2009-11-26T14:50:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6555"},"modified":"2022-01-25T15:00:05","modified_gmt":"2022-01-25T15:00:05","slug":"biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption-2","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption-2\/","title":{"rendered":"Biological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption"},"content":{"rendered":"
\n

Shoichi Nishise<\/a>,Yuji Takeda<\/a>,Yuko Nishise<\/a>,Shoichiro Fujishima<\/a>,Tomohiko Orii<\/a>,Sayaka Otake<\/a>,Takeshi Sato<\/a>,Yu Sasaki<\/a>,Hiroaki Takeda<\/a>,Sumio Kawata<\/a><\/p>\n<\/div>\n\n

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Biological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption. Therap. Apher. Dial. 2009 13(6), 509\u2013514.\u00a0doi:10.1111\/j.1744-9987.2009.00779.x\u00a0<\/p>\n<\/div>\n\n

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Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. The aim of this study was to investigate the effect of C5a on interleukin-1 receptor antagonist (IL-1ra) and hepatocyte growth factor (HGF) generation in granulocyte and monocyte adsorption. Peripheral blood containing nafamostat mesilate as an endogenous complement activation inhibitor was divided into four groups: (1) no recombinant C5a added, no contact with cellulose acetate (CA) beads (control group); (2) no C5a added, contact with CA beads; (3) C5a added, no contact with CA beads; and (4) C5a added, contact with CA beads. After incubation, IL-1ra and HGF in plasma were measured. IL-1ra was significantly higher in group 3, in which only C5a was added in the absence of CA beads, compared to groups 2 (P<\/em>\u2003<\u20030.01) and 4 (P<\/em>\u2003<\u20030.05). HGF was significantly higher only in group 4, in which C5a was added in the presence of CA beads (P<\/em>\u2003<\u20030.05), but did not increase in the absence of CA beads. C5a can directly induce IL-1ra generation without the granulocyte and monocyte adsorption stimuli to CA beads, but can synergistically induce HGF generation with the adsorption stimuli, indicating C5a has different effects on IL-1ra and HGF generation.<\/p>\n<\/div>\n\n

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https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2009.00779.x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Shoichi Nishise,Yuji Takeda,Yuko Nishise,Shoichiro Fujishima,Tomohiko Orii,Sayaka Otake,Takeshi Sato,Yu Sasaki,Hiroaki Takeda,Sumio Kawata Biological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption. Therap. Apher. Dial. 2009 13(6), 509\u2013514.\u00a0doi:10.1111\/j.1744-9987.2009.00779.x\u00a0 Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed […]<\/p>\n","protected":false},"template":"","scientific_tags":[471,472,424,474,473,386,173,306],"class_list":["post-6555","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-anaphylatoxin-c5a","scientific_tags-antinflammatory","scientific_tags-gma","scientific_tags-hgf","scientific_tags-il-1ra","scientific_tags-leukocyte","scientific_tags-moa","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"\nBiological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption-2\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Shoichi Nishise,Yuji Takeda,Yuko Nishise,Shoichiro Fujishima,Tomohiko Orii,Sayaka Otake,Takeshi Sato,Yu Sasaki,Hiroaki Takeda,Sumio Kawata Biological Effect of Anaphylatoxin C5a on the Generation of Anti-inflammatory Substances in Leukocyte Adsorption. Therap. Apher. Dial. 2009 13(6), 509\u2013514.\u00a0doi:10.1111\/j.1744-9987.2009.00779.x\u00a0 Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. 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Therap. Apher. Dial. 2009 13(6), 509\u2013514.\u00a0doi:10.1111\/j.1744-9987.2009.00779.x\u00a0 Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. 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