{"id":6468,"date":"2018-11-24T11:45:00","date_gmt":"2018-11-24T11:45:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6468"},"modified":"2024-05-02T11:16:00","modified_gmt":"2024-05-02T09:16:00","slug":"monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/","title":{"rendered":"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis"},"content":{"rendered":"
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Sachiko Hirose<\/a>\u00a01<\/a><\/sup>,\u00a0Qingshun Lin<\/a>\u00a01<\/a><\/sup>,\u00a0Mareki Ohtsuji<\/a>\u00a01<\/a><\/sup>,\u00a0Hiroyuki Nishimura<\/a>\u00a01<\/a><\/sup>,\u00a0J Sjef Verbeek<\/a>\u00a01<\/a><\/sup> , Int Immunol. 2019 Oct 16;31(11):687-696<\/p>\n<\/div>\n\n

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AbstractMonocytes are evolutionally conserved innate immune cells that play essential roles for the protection of the host against pathogens and also produce several inflammatory cytokines. Thus, the aberrant functioning of monocytes may affect not only host defense but also the development of inflammatory diseases. Monocytes are a heterogeneous population with phenotypical and functional differences. Most recent studies have shown that monocytes are divided into three subsets, namely classical, intermediate and non-classical subsets, both in humans and mice. Accumulating evidence showed that monocyte activation is associated with the disease progression in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, it remains to be determined how monocytes contribute to the disease process and which subset is involved. In this review, we discuss the pathogenic role of monocyte subsets in SLE and RA on the basis of current studies by ourselves and others to shed light on the suitability of monocyte-targeted therapies in these diseases.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/31063541\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Sachiko Hirose\u00a01,\u00a0Qingshun Lin\u00a01,\u00a0Mareki Ohtsuji\u00a01,\u00a0Hiroyuki Nishimura\u00a01,\u00a0J Sjef Verbeek\u00a01 , Int Immunol. 2019 Oct 16;31(11):687-696 AbstractMonocytes are evolutionally conserved innate immune cells that play essential roles for the protection of the host against pathogens and also produce several inflammatory cytokines. Thus, the aberrant functioning of monocytes may affect not only host defense but also the development of […]<\/p>\n","protected":false},"template":"","scientific_tags":[456,453],"class_list":["post-6468","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-autoimmune-disease","scientific_tags-rheumatoid-arthritis"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/31063541\/<\/a>"},"yoast_head":"\nMonocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Sachiko Hirose\u00a01,\u00a0Qingshun Lin\u00a01,\u00a0Mareki Ohtsuji\u00a01,\u00a0Hiroyuki Nishimura\u00a01,\u00a0J Sjef Verbeek\u00a01 , Int Immunol. 2019 Oct 16;31(11):687-696 AbstractMonocytes are evolutionally conserved innate immune cells that play essential roles for the protection of the host against pathogens and also produce several inflammatory cytokines. Thus, the aberrant functioning of monocytes may affect not only host defense but also the development of […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-02T09:16:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/\",\"name\":\"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2018-11-24T11:45:00+00:00\",\"dateModified\":\"2024-05-02T09:16:00+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/monocyte-subsets-involved-in-the-development-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis\/","og_locale":"es_ES","og_type":"article","og_title":"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis - Adacyte","og_description":"Sachiko Hirose\u00a01,\u00a0Qingshun Lin\u00a01,\u00a0Mareki Ohtsuji\u00a01,\u00a0Hiroyuki Nishimura\u00a01,\u00a0J Sjef Verbeek\u00a01 , Int Immunol. 2019 Oct 16;31(11):687-696 AbstractMonocytes are evolutionally conserved innate immune cells that play essential roles for the protection of the host against pathogens and also produce several inflammatory cytokines. 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