{"id":5831,"date":"1998-07-28T10:28:00","date_gmt":"1998-07-28T10:28:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=5831"},"modified":"2021-07-28T10:30:51","modified_gmt":"2021-07-28T10:30:51","slug":"granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect\/","title":{"rendered":"Granulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect"},"content":{"rendered":"
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B.J. Rembacken<\/a>,\u00a0H.E. Newbould<\/a>,\u00a0S.J. Richards<\/a>,\u00a0S.A. Misbah<\/a>,\u00a0M.E. Dixon<\/a>,\u00a0D.M. Chalmers<\/a>,\u00a0A.T.R. Axon<\/a>, https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x<\/a><\/p>\n<\/div>\n\n

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We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column (GI, Otsuka Pharmaceutical Co., Ltd., London, U.K.). We found a mean reduction in circulating granulocytes of 1.29 \u00d7 109<\/sup>\u00a0cells\/L with no significant alterations in red blood cell monocyte, total lymphocyte, absolute T-helper, or T-cytotoxic lymphocyte counts. There were no significant changes in complement levels or immunoglobulin subclasses. There was a signifycant increase in granulocyte adhesion and a reduction in L-selectin expression. The removal of granulocytes is unlikely to explain the effect of granulocytapheresis. The markedly increased expression of \u03b1m<\/sub>\u00a0integrin\/Mac-1 and low L-selectin expression alter the capability of granulocytes to migrate to sites of inflammation and may be responsible for the improvement observed in patients treated with granulocyte apheresis.<\/p>\n<\/div>\n\n

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Granulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect – Rembacken – 1998 – Therapeutic Apheresis – Wiley Online Library<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

B.J. Rembacken,\u00a0H.E. Newbould,\u00a0S.J. Richards,\u00a0S.A. Misbah,\u00a0M.E. Dixon,\u00a0D.M. Chalmers,\u00a0A.T.R. Axon, https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column (GI, Otsuka Pharmaceutical Co., Ltd., London, U.K.). We […]<\/p>\n","protected":false},"template":"","scientific_tags":[],"class_list":["post-5831","scientific-corner","type-scientific-corner","status-publish","hentry"],"acf":[],"yoast_head":"\nGranulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect - Adacyte\" \/>\n<meta property=\"og:description\" content=\"B.J. Rembacken,\u00a0H.E. Newbould,\u00a0S.J. Richards,\u00a0S.A. Misbah,\u00a0M.E. Dixon,\u00a0D.M. Chalmers,\u00a0A.T.R. Axon, https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column (GI, Otsuka Pharmaceutical Co., Ltd., London, U.K.). 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