{"id":5633,"date":"2008-07-05T15:00:00","date_gmt":"2008-07-05T15:00:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=5633"},"modified":"2022-04-12T13:37:01","modified_gmt":"2022-04-12T13:37:01","slug":"cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/","title":{"rendered":"Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Danese+S&amp;cauthor_id=18382085\">Silvio Danese<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18382085\/#affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Angelucci+E&amp;cauthor_id=18382085\">Erika Angelucci<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Stefanelli+T&amp;cauthor_id=18382085\">Tommaso Stefanelli<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Omodei+P&amp;cauthor_id=18382085\">Paolo Omodei<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Luigiano+C&amp;cauthor_id=18382085\">Carmelo Luigiano<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Finazzi+S&amp;cauthor_id=18382085\">Silvia Finazzi<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pagano+N&amp;cauthor_id=18382085\">Nico Pagano<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Repici+A&amp;cauthor_id=18382085\">Alessandro Repici<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Vecchi+M&amp;cauthor_id=18382085\">Maurizio Vecchi<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Malesci+A&amp;cauthor_id=18382085\">Alberto Malesci<\/a>, Digestion. 2008;77(2):96-107.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Ulcerative colitis and Crohn&#8217;s disease are inflammatory bowel diseases with a chronic relapsing course. Management of both conditions is far from being fully satisfactory. For this reason in the last decade a large number of biological therapies, targeting cytokines involved in intestinal inflammation, has been developed with various results in terms of efficacy, safety and costs. Activated granulocytes and monocytes represent the major sources of pro-inflammatory cytokines in the intestinal mucosa, playing a pivotal role in inducing and maintaining intestinal inflammation. Leukocytapheresis using an adsorptive carrier-based system (Adacolumn) or a removal filter column (Cellsorba) has been proposed as a feasible, safe and effective therapy for ulcerative colitis and Crohn&#8217;s disease.\u00a0The objective of this paper is to provide an overview on the current knowledge about mechanisms of action, available clinical data and the possible future perspectives for the use of Adacolumn and Cellsorba in the management of inflammatory bowel diseases.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18382085\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18382085\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Silvio Danese&nbsp;1,&nbsp;Erika Angelucci,&nbsp;Tommaso Stefanelli,&nbsp;Paolo Omodei,&nbsp;Carmelo Luigiano,&nbsp;Silvia Finazzi,&nbsp;Nico Pagano,&nbsp;Alessandro Repici,&nbsp;Maurizio Vecchi,&nbsp;Alberto Malesci, Digestion. 2008;77(2):96-107. Ulcerative colitis and Crohn&#8217;s disease are inflammatory bowel diseases with a chronic relapsing course. Management of both conditions is far from being fully satisfactory. For this reason in the last decade a large number of biological therapies, targeting cytokines involved in intestinal [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[159,314,424,74,173,55,185,135,306],"class_list":["post-5633","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-crohns-disease","scientific_tags-digestive","scientific_tags-gma","scientific_tags-leukocytapheresis","scientific_tags-moa","scientific_tags-steroid-dependent","scientific_tags-steroid-naive","scientific_tags-steroid-refractory","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Silvio Danese&nbsp;1,&nbsp;Erika Angelucci,&nbsp;Tommaso Stefanelli,&nbsp;Paolo Omodei,&nbsp;Carmelo Luigiano,&nbsp;Silvia Finazzi,&nbsp;Nico Pagano,&nbsp;Alessandro Repici,&nbsp;Maurizio Vecchi,&nbsp;Alberto Malesci, Digestion. 2008;77(2):96-107. Ulcerative colitis and Crohn&#8217;s disease are inflammatory bowel diseases with a chronic relapsing course. Management of both conditions is far from being fully satisfactory. For this reason in the last decade a large number of biological therapies, targeting cytokines involved in intestinal [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-12T13:37:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/\",\"name\":\"Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2008-07-05T15:00:00+00:00\",\"dateModified\":\"2022-04-12T13:37:01+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/cytapheresis-in-inflammatory-bowel-diseases-current-evidence-and-perspectives\/","og_locale":"es_ES","og_type":"article","og_title":"Cytapheresis in Inflammatory Bowel Diseases: Current Evidence and Perspectives - Adacyte","og_description":"Silvio Danese&nbsp;1,&nbsp;Erika Angelucci,&nbsp;Tommaso Stefanelli,&nbsp;Paolo Omodei,&nbsp;Carmelo Luigiano,&nbsp;Silvia Finazzi,&nbsp;Nico Pagano,&nbsp;Alessandro Repici,&nbsp;Maurizio Vecchi,&nbsp;Alberto Malesci, Digestion. 2008;77(2):96-107. Ulcerative colitis and Crohn&#8217;s disease are inflammatory bowel diseases with a chronic relapsing course. Management of both conditions is far from being fully satisfactory. 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