{"id":5606,"date":"2010-07-01T09:56:00","date_gmt":"2010-07-01T09:56:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=5606"},"modified":"2021-07-09T11:21:43","modified_gmt":"2021-07-09T11:21:43","slug":"induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/","title":{"rendered":"Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro"},"content":{"rendered":"
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Fumie Jimma<\/a> 1<\/a><\/sup>, Yuji Takeda<\/a>, Kenta Kaneda<\/a>, Ichiro Wakabayashi<\/a> , J Clin Apher. 2010;25(4):216-22.<\/p>\n<\/div>\n\n

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Gene expression of transforming growth factor-beta (TGF-beta) is needed to induce expression of transcription factor forkhead box P3 (Foxp3), which is required for the development and function of regulatory T (Treg) cells. The number of circulating Treg cells and the level of Foxp3 expression increase during granulocyte and monocyte apheresis (GMA), a useful therapy for ulcerative colitis. However, the mechanism underlying GMA-induced Foxp3 expression is unknown. We found that the level of TGF-beta mRNA in peripheral blood mononuclear cells (PBMCs) was augmented just after treatment of peripheral blood with a GMA carrier, cellulose acetate beads, in vitro and that Foxp3 expression in PBMCs increased after culturing these cells for 5 days after the treatment. The augmentation of TGF-beta expression was observed in CD3(-) PBMCs but not in CD3(+) T cells. Furthermore, the increase in Foxp3 expression in T cells depended on co-culture with CD3(-) PBMCs. We conclude that cellulose acetate beads have an ability to induce Foxp3 expression in peripheral blood T cells via augmentation of TGF-beta expression in CD3(-) PBMCs.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/20544711\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Fumie Jimma 1, Yuji Takeda, Kenta Kaneda, Ichiro Wakabayashi , J Clin Apher. 2010;25(4):216-22. Gene expression of transforming growth factor-beta (TGF-beta) is needed to induce expression of transcription factor forkhead box P3 (Foxp3), which is required for the development and function of regulatory T (Treg) cells. The number of circulating Treg cells and the level of Foxp3 expression increase […]<\/p>\n","protected":false},"template":"","scientific_tags":[],"class_list":["post-5606","scientific-corner","type-scientific-corner","status-publish","hentry"],"acf":{"sc_authors":""},"yoast_head":"\nInduction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Fumie Jimma 1, Yuji Takeda, Kenta Kaneda, Ichiro Wakabayashi , J Clin Apher. 2010;25(4):216-22. Gene expression of transforming growth factor-beta (TGF-beta) is needed to induce expression of transcription factor forkhead box P3 (Foxp3), which is required for the development and function of regulatory T (Treg) cells. The number of circulating Treg cells and the level of Foxp3 expression increase […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-09T11:21:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/\",\"name\":\"Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2010-07-01T09:56:00+00:00\",\"dateModified\":\"2021-07-09T11:21:43+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro-induction-of-foxp3-expression-in-t-cells-by-cellulose-acetate-beads-in-vitro\/","og_locale":"es_ES","og_type":"article","og_title":"Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro.Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro - Adacyte","og_description":"Fumie Jimma 1, Yuji Takeda, Kenta Kaneda, Ichiro Wakabayashi , J Clin Apher. 2010;25(4):216-22. Gene expression of transforming growth factor-beta (TGF-beta) is needed to induce expression of transcription factor forkhead box P3 (Foxp3), which is required for the development and function of regulatory T (Treg) cells. 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