{"id":4022,"date":"2011-04-24T13:44:00","date_gmt":"2011-04-24T13:44:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=4022"},"modified":"2022-04-01T13:36:11","modified_gmt":"2022-04-01T13:36:11","slug":"peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/","title":{"rendered":"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis."},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Toshimi Chibaa, Mikiya Endob, Shoko Matsushitab, Mika Sasakib, Shoichi Chidab, Yosuke Toyaa, Satoshi Kasugaia, Nozomi  atsudaa, Shunsuke Orikasaa, Yukito Abikoa, Norihiko Kudaraa, Shuhei Oanaa, Masaki Endoa, Kazuyuki Suzukia\u00a9 2011 S. Karger AG, BaselISSN 1662\u20130631<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Granulocyte and monocyte adsorptive apheresis (GMA) is reportedly useful as induction therapy for Crohn\u2019s disease (CD). However, the effects of GMA on CD64 have not been well characterized. We report here our assessment of CD64 expression on neutrophils before and after treatment with GMA in two patients with CD. The severity of CD was assessed with the CD activity index (CDAI). The duration of each GMA session was 60 min at a flow rate of 30 ml\/min as per protocol. CD64 expression on neutrophils was measured by analyzing whole blood with a FACScan flow cytometer. In case 1, CD64 levels after each session of GMA tended to decrease compared to pretreatment levels, whereas in case 2, CD64 levels dropped significantly after treatment. The CDAI decreased after GMA in both cases 1 and 2. A significant correlation was noted between CDAI scores and CD64 levels in both cases. In conclusion, GMA reduced blood CD64 levels, which would be an important factor for the decrease of CDAI scores.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3250654\/pdf\/crg0005-0667.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3250654\/pdf\/crg0005-0667.pdf<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Toshimi Chibaa, Mikiya Endob, Shoko Matsushitab, Mika Sasakib, Shoichi Chidab, Yosuke Toyaa, Satoshi Kasugaia, Nozomi atsudaa, Shunsuke Orikasaa, Yukito Abikoa, Norihiko Kudaraa, Shuhei Oanaa, Masaki Endoa, Kazuyuki Suzukia\u00a9 2011 S. Karger AG, BaselISSN 1662\u20130631 Granulocyte and monocyte adsorptive apheresis (GMA) is reportedly useful as induction therapy for Crohn\u2019s disease (CD). However, the effects of GMA [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[608,159,79,609,157,610,312,315],"class_list":["post-4022","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-activated-neutrophils","scientific_tags-crohns-disease","scientific_tags-cytokines","scientific_tags-effective","scientific_tags-efficacy","scientific_tags-fcgr","scientific_tags-immunology","scientific_tags-others"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis. - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis. - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Toshimi Chibaa, Mikiya Endob, Shoko Matsushitab, Mika Sasakib, Shoichi Chidab, Yosuke Toyaa, Satoshi Kasugaia, Nozomi atsudaa, Shunsuke Orikasaa, Yukito Abikoa, Norihiko Kudaraa, Shuhei Oanaa, Masaki Endoa, Kazuyuki Suzukia\u00a9 2011 S. Karger AG, BaselISSN 1662\u20130631 Granulocyte and monocyte adsorptive apheresis (GMA) is reportedly useful as induction therapy for Crohn\u2019s disease (CD). However, the effects of GMA [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-01T13:36:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/\",\"name\":\"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis. - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2011-04-24T13:44:00+00:00\",\"dateModified\":\"2022-04-01T13:36:11+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis. - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/peripheral-blood-cd64-levels-decrease-in-crohns-disease-following-granulocyte-and-monocyte-adsorptive-apheresis\/","og_locale":"es_ES","og_type":"article","og_title":"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis. - Adacyte","og_description":"Toshimi Chibaa, Mikiya Endob, Shoko Matsushitab, Mika Sasakib, Shoichi Chidab, Yosuke Toyaa, Satoshi Kasugaia, Nozomi atsudaa, Shunsuke Orikasaa, Yukito Abikoa, Norihiko Kudaraa, Shuhei Oanaa, Masaki Endoa, Kazuyuki Suzukia\u00a9 2011 S. 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