{"id":3974,"date":"2015-04-25T09:46:00","date_gmt":"2015-04-25T09:46:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=3974"},"modified":"2022-08-04T15:21:04","modified_gmt":"2022-08-04T15:21:04","slug":"granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/","title":{"rendered":"Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not?"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kruis+W&amp;cauthor_id=26112696\">Wolfgang Kruis<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26112696\/#affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nguyen+P&amp;cauthor_id=26112696\">Phuong Nguyen<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Morgenstern+J&amp;cauthor_id=26112696\">Julia Morgenstern<\/a>, Digestion. 2015;92(1):39-44.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong><em>Background and Aims:<\/em><\/strong>\u00a0Adsorptive granulocyte\/monocyte apheresis (GMA) has shown promising efficacy in the treatment of patients with ulcerative colitis (UC). But a sham-controlled study was negative. A post-hoc analysis of this trial may haul out patients responding to GMA.\u00a0<strong><em>Methods:<\/em><\/strong>\u00a0A total of 168 UC patients with a disease activity (DAI) between 6 and 11 were enrolled in this study. Out of 168 patients, 112 received GMA and 56 sham apheresis. The basis for this post hoc analysis is the clinical study report issued by Otsuka America Pharmaceutical.\u00a0<strong><em>Results:<\/em><\/strong>\u00a0Baseline histology was available for 165 patients. Only 38% (63 of 165) of patients showed microscopic erosion\/ulceration (group P). The remaining 62% of patients did not show microscopic erosion\/ulceration (group A). The patients in group P showed significantly higher DAI, flexible proctosigmoidoscopy score and neutrophil infiltration into the colonic mucosa than those in group A (p = 0.0132, p = 0.0243 and p &lt; 0.0001, respectively). Likewise, group P patients had a significantly (p = 0.0275) higher remission rate (11 of 46; 23.9%) when treated with GMA than with sham procedure (0 of 17; 0%).\u00a0<strong><em>Conclusions:<\/em><\/strong> Patients in group P who had more active UC than those in group A showed clear clinical efficacy in response to GMA. We believe that true DAI should be specified for further randomized controlled trials.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26112696\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26112696\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Wolfgang Kruis&nbsp;1,&nbsp;Phuong Nguyen,&nbsp;Julia Morgenstern, Digestion. 2015;92(1):39-44. Background and Aims:\u00a0Adsorptive granulocyte\/monocyte apheresis (GMA) has shown promising efficacy in the treatment of patients with ulcerative colitis (UC). But a sham-controlled study was negative. A post-hoc analysis of this trial may haul out patients responding to GMA.\u00a0Methods:\u00a0A total of 168 UC patients with a disease activity (DAI) between [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147],"class_list":["post-3974","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not? - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not? - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Wolfgang Kruis&nbsp;1,&nbsp;Phuong Nguyen,&nbsp;Julia Morgenstern, Digestion. 2015;92(1):39-44. Background and Aims:\u00a0Adsorptive granulocyte\/monocyte apheresis (GMA) has shown promising efficacy in the treatment of patients with ulcerative colitis (UC). But a sham-controlled study was negative. A post-hoc analysis of this trial may haul out patients responding to GMA.\u00a0Methods:\u00a0A total of 168 UC patients with a disease activity (DAI) between [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-04T15:21:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/\",\"name\":\"Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not? - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2015-04-25T09:46:00+00:00\",\"dateModified\":\"2022-08-04T15:21:04+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not? - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-monocyte-adsorptive-apheresis-in-moderate-to-severe-ulcerative-colitis-effective-or-not\/","og_locale":"es_ES","og_type":"article","og_title":"Granulocyte\/Monocyte Adsorptive Apheresis in Moderate to Severe Ulcerative Colitis-Effective or Not? - Adacyte","og_description":"Wolfgang Kruis&nbsp;1,&nbsp;Phuong Nguyen,&nbsp;Julia Morgenstern, Digestion. 2015;92(1):39-44. 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