{"id":3930,"date":"2018-04-26T07:24:00","date_gmt":"2018-04-26T07:24:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=3930"},"modified":"2024-05-02T11:24:37","modified_gmt":"2024-05-02T09:24:37","slug":"granulocyte-and-monocyte-apheresis-for-induction-of-remission-in-children-with-new-onset-inflammatory-bowel-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-for-induction-of-remission-in-children-with-new-onset-inflammatory-bowel-colitis\/","title":{"rendered":"Granulocyte and Monocyte Apheresis for Induction of Remission in Children With New Onset Inflammatory Bowel Colitis."},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rolandsdotter+H&amp;cauthor_id=28604509\">Helena Rolandsdotter<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-1\">1<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-2\">2<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Eberhardson+M&amp;cauthor_id=28604509\">Michael Eberhardson<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-1\">1<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fagerberg+UL&amp;cauthor_id=28604509\">Ulrika L Fagerberg<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-4\">4<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-5\">5<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Finkel+Y&amp;cauthor_id=28604509\">Yigael Finkel<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-1\">1<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/#affiliation-2\">2<\/a><\/sup> , J Pediatr Gastroenterol Nutr 2018 Jan;66(1):84-89.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Objective:\u00a0<\/strong>The aim of the study was to analyze the effect of granulocyte and monocyte apheresis (GMA) with mesalazine for induction of remission in pediatric patients with newly onset chronic inflammatory bowel disease (IBD) colitis. <strong>Methods:\u00a0<\/strong>Thirteen pediatric patients with newly onset extensive IBD colitis were investigated per the ECCO\/ESPGHAN IBD protocol. Of these 13, 12 received 10 treatments with Adacolumn (ADA) during a median of 6.25 weeks in combination with low-to-moderate doses of mesalazine, which was continued after apheresis. A control colonoscopy was performed 12 to 16 weeks after GMA treatment. Primary outcomes were mucosal healing (Mayo endoscopic score) and histopathologic grading of biopsies. A secondary outcome was disease activity as measured by the Pediatric Ulcerative Colitis Activity Index. <strong>Results:\u00a0<\/strong>Twelve children (6 girls) with a median age of 14.6 years and a median duration of symptoms at diagnosis of 3.2 months received all planned 10 treatment sessions with ADA. Ten of 12 patients had pancolitis and 2 of 12 extensive colitis. A final diagnosis, however, indicated ulcerative colitis in 10 children and Crohn disease in 2 children. At control colonoscopy, 8 of 12 children were in clinical remission and the Mayo endoscopic score showed significant improvement in 9 of 12 patients (P = 0.006). Complete microscopic remission, according to the Geboes score, was observed in 2 patients. <strong>Conclusions:\u00a0<\/strong>In this small study GMA for induction of remission of newly onset pediatric IBD colitis was effective in 8 of 12 patients. Further controlled studies are warranted to confirm the efficacy of this treatment model.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Helena Rolandsdotter&nbsp;1&nbsp;2,&nbsp;Michael Eberhardson&nbsp;1&nbsp;3,&nbsp;Ulrika L Fagerberg&nbsp;4&nbsp;5,&nbsp;Yigael Finkel&nbsp;1&nbsp;2 , J Pediatr Gastroenterol Nutr 2018 Jan;66(1):84-89. Objective:\u00a0The aim of the study was to analyze the effect of granulocyte and monocyte apheresis (GMA) with mesalazine for induction of remission in pediatric patients with newly onset chronic inflammatory bowel disease (IBD) colitis. Methods:\u00a0Thirteen pediatric patients with newly onset extensive IBD [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,312,74,76,75,306],"class_list":["post-3930","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-immunology","scientific_tags-leukocytapheresis","scientific_tags-patient","scientific_tags-qol","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28604509\/<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte and Monocyte Apheresis for Induction of Remission in Children With New Onset Inflammatory Bowel Colitis. - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-apheresis-for-induction-of-remission-in-children-with-new-onset-inflammatory-bowel-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and Monocyte Apheresis for Induction of Remission in Children With New Onset Inflammatory Bowel Colitis. - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Helena Rolandsdotter&nbsp;1&nbsp;2,&nbsp;Michael Eberhardson&nbsp;1&nbsp;3,&nbsp;Ulrika L Fagerberg&nbsp;4&nbsp;5,&nbsp;Yigael Finkel&nbsp;1&nbsp;2 , J Pediatr Gastroenterol Nutr 2018 Jan;66(1):84-89. Objective:\u00a0The aim of the study was to analyze the effect of granulocyte and monocyte apheresis (GMA) with mesalazine for induction of remission in pediatric patients with newly onset chronic inflammatory bowel disease (IBD) colitis. 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