{"id":11083,"date":"2005-02-05T17:03:00","date_gmt":"2005-02-05T16:03:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11083"},"modified":"2025-08-08T17:06:45","modified_gmt":"2025-08-08T15:06:45","slug":"safety-and-efficacy-of-extracorporeal-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-severe-persistent-bronchial-asthma","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/safety-and-efficacy-of-extracorporeal-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-severe-persistent-bronchial-asthma\/","title":{"rendered":"Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma"},"content":{"rendered":"
\n

Tamotsu Ishizuka<\/a>\u00a01<\/a><\/sup>,\u00a0Tadayoshi Kawata<\/a>,\u00a0Yasuo Shimizu<\/a>,\u00a0Mitsuyoshi Utsugi<\/a>,\u00a0Katsuaki Endou<\/a>,\u00a0Takeshi Hisada<\/a>,\u00a0Kunio Dobashi<\/a>,\u00a0Tsugio Nakazawa<\/a>,\u00a0Masatomo Mori<\/a><\/p>\n<\/div>\n\n

\n

Inflammation.\u00a02005 Feb;29(1):9-16.\u00a0doi: 10.1007\/s10753-006-8963-5.<\/p>\n<\/div>\n\n

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The Adacolumn is an adsorptive-type extracorporeal device, which is filled with cellulose diacetate beads that selectively adsorb granulocytes and monocytes. Patients with severe persistent asthma experience highly variable continuous symptoms and severe exacerbations in spite of medication based on inhaled glucocorticosteroids. Granulocyte and monocyte adsorption apheresis using extracorporeal circulation through the Adacolumn was performed in nine patients with severe persistent asthma. The extracorporeal circulation through the Adacolumn was performed once a week for 5 weeks. We were able to perform this therapy without any severe adverse effects in all patients, although one patient complained of general fatigue just after the circulations. In six of the nine patients, the increase in peak expiratory flow (PEF) was more than 50 mL\/min. The average increase in morning PEF was 23.3% while that in the evening PEF was 26.4% after the therapy. This therapy was not harmful for patients with severe persistent asthma. A placebo-controlled study will be desired to evaluate the efficacy of this nonpharmacological strategy accurately.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Tamotsu Ishizuka\u00a01,\u00a0Tadayoshi Kawata,\u00a0Yasuo Shimizu,\u00a0Mitsuyoshi Utsugi,\u00a0Katsuaki Endou,\u00a0Takeshi Hisada,\u00a0Kunio Dobashi,\u00a0Tsugio Nakazawa,\u00a0Masatomo Mori Inflammation.\u00a02005 Feb;29(1):9-16.\u00a0doi: 10.1007\/s10753-006-8963-5. The Adacolumn is an adsorptive-type extracorporeal device, which is filled with cellulose diacetate beads that selectively adsorb granulocytes and monocytes. Patients with severe persistent asthma experience highly variable continuous symptoms and severe exacerbations in spite of medication based on inhaled glucocorticosteroids. Granulocyte […]<\/p>\n","protected":false},"template":"","scientific_tags":[914,157,916,424,917,915,156],"class_list":["post-11083","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-asthma","scientific_tags-efficacy","scientific_tags-glucocorticosteroids","scientific_tags-gma","scientific_tags-pef","scientific_tags-persistent","scientific_tags-safety"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/16502341\/<\/a>\r\n\r\n "},"yoast_head":"\nSafety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/safety-and-efficacy-of-extracorporeal-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-severe-persistent-bronchial-asthma\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Tamotsu Ishizuka\u00a01,\u00a0Tadayoshi Kawata,\u00a0Yasuo Shimizu,\u00a0Mitsuyoshi Utsugi,\u00a0Katsuaki Endou,\u00a0Takeshi Hisada,\u00a0Kunio Dobashi,\u00a0Tsugio Nakazawa,\u00a0Masatomo Mori Inflammation.\u00a02005 Feb;29(1):9-16.\u00a0doi: 10.1007\/s10753-006-8963-5. 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