{"id":11082,"date":"2022-01-21T16:49:00","date_gmt":"2022-01-21T15:49:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11082"},"modified":"2025-08-08T16:53:42","modified_gmt":"2025-08-08T14:53:42","slug":"treatment-options-and-goals-for-patients-with-generalized-pustular-psoriasis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/treatment-options-and-goals-for-patients-with-generalized-pustular-psoriasis\/","title":{"rendered":"Treatment Options and Goals for Patients with Generalized Pustular Psoriasis"},"content":{"rendered":"
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James Krueger<\/a>\u00a01<\/a><\/sup>,\u00a0Llu\u00eds Puig<\/a>\u00a02<\/a><\/sup>,\u00a0Diamant Tha\u00e7i<\/a>\u00a03<\/a><\/sup><\/p>\n<\/div>\n\n

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Am J Clin Dermatol.\u00a02022 Jan;23(Suppl 1):51-64.\u00a0doi: 10.1007\/s40257-021-00658-9.\u00a0Epub 2022 Jan 21.<\/p>\n<\/div>\n\n

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Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disorder characterized by sudden widespread eruption of superficial sterile pustules with or without systemic inflammation. GPP flares can be life-threatening if untreated due to potential severe complications such as cardiovascular failure and serious infections. Currently, there are no GPP-specific therapies approved in the USA or Europe. Retinoids, cyclosporine, and methotrexate are the most commonly used non-biologic therapies for GPP. The evidence that supports the currently available treatment options is mainly based on case reports and small, open-label, single-arm studies. However, recent advances in our understanding of the pathogenic mechanisms of GPP and the identification of gene mutations linked to the disease have paved the way for the development of specific targeted therapies that selectively suppress the autoinflammatory and autoimmune mechanisms induced during GPP flares. Several biologic agents that target key cytokines involved in the activation of inflammatory pathways, such as tumor necrosis factor-\u03b1 blockers and interleukin (IL)-17, IL-23, and IL-12 inhibitors, have emerged as potential treatments for GPP, with several being approved in Japan. The evidence supporting the efficacy of these agents is mainly derived from small, uncontrolled trials. A notable recent advance is the discovery of IL36RN mutations and the central role of IL-36 receptor ligands in the pathogenesis of GPP, which has defined key therapeutic targets for the disease. Biologic agents that target the IL-36 pathway have demonstrated promising efficacy in patients with GPP, marking the beginning of a new era of targeted therapy for GPP.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

James Krueger\u00a01,\u00a0Llu\u00eds Puig\u00a02,\u00a0Diamant Tha\u00e7i\u00a03 Am J Clin Dermatol.\u00a02022 Jan;23(Suppl 1):51-64.\u00a0doi: 10.1007\/s40257-021-00658-9.\u00a0Epub 2022 Jan 21. Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disorder characterized by sudden widespread eruption of superficial sterile pustules with or without systemic inflammation. GPP flares can be life-threatening if untreated due to potential severe complications such as cardiovascular failure […]<\/p>\n","protected":false},"template":"","scientific_tags":[698,892,913,92,134,486,348,424,130,905,912,464],"class_list":["post-11082","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-anti-il-17a","scientific_tags-anti-il12-23","scientific_tags-anti-il36","scientific_tags-anti-tnf","scientific_tags-biologics","scientific_tags-cyclosporine","scientific_tags-generalized-pustular-psoriasis","scientific_tags-gma","scientific_tags-il36rn","scientific_tags-methotrexate","scientific_tags-retimoids","scientific_tags-treament"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/35061230\/<\/a>\r\n\r\nhttps:\/\/link.springer.com\/article\/10.1007\/s40257-021-00658-9<\/a>"},"yoast_head":"\nTreatment Options and Goals for Patients with Generalized Pustular Psoriasis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treatment-options-and-goals-for-patients-with-generalized-pustular-psoriasis\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treatment Options and Goals for Patients with Generalized Pustular Psoriasis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"James Krueger\u00a01,\u00a0Llu\u00eds Puig\u00a02,\u00a0Diamant Tha\u00e7i\u00a03 Am J Clin Dermatol.\u00a02022 Jan;23(Suppl 1):51-64.\u00a0doi: 10.1007\/s40257-021-00658-9.\u00a0Epub 2022 Jan 21. 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