{"id":11075,"date":"2024-05-13T13:57:00","date_gmt":"2024-05-13T11:57:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11075"},"modified":"2025-08-08T14:04:57","modified_gmt":"2025-08-08T12:04:57","slug":"origin-and-function-of-monocytes-in-inflammatory-bowel-disease","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/origin-and-function-of-monocytes-in-inflammatory-bowel-disease\/","title":{"rendered":"Origin and Function of Monocytes in Inflammatory Bowel Disease"},"content":{"rendered":"
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Xiping Liao<\/a>\u00a0#<\/a>\u00a01<\/a>\u00a02<\/a><\/sup>,\u00a0Ji Liu<\/a>\u00a0#<\/a>\u00a03<\/a><\/sup>,\u00a0Xiaolong Guo<\/a>\u00a01<\/a><\/sup>,\u00a0Ruiping Meng<\/a>\u00a01<\/a><\/sup>,\u00a0Wei Zhang<\/a>\u00a01<\/a><\/sup>,\u00a0Jianyun Zhou<\/a>\u00a01<\/a><\/sup>,\u00a0Xia Xie<\/a>\u00a01<\/a>\u00a02<\/a><\/sup>,\u00a0Hongli Zhou<\/a>\u00a01<\/a><\/sup><\/p>\n<\/div>\n\n

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J Inflamm Res.\u00a02024 May 13:17:2897-2914.\u00a0doi: 10.2147\/JIR.S450801.\u00a0eCollection 2024.<\/p>\n<\/div>\n\n

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Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic disease resulting from the interaction of various factors such as social elements, autoimmunity, genetics, and gut microbiota. Alarmingly, recent epidemiological data points to a surging incidence of IBD, underscoring an urgent imperative: to delineate the intricate mechanisms driving its onset. Such insights are paramount, not only for enhancing our comprehension of IBD pathogenesis but also for refining diagnostic and therapeutic paradigms. Monocytes, significant immune cells derived from the bone marrow, serve as precursors to macrophages (M\u03c6s) and dendritic cells (DCs) in the inflammatory response of IBD. Within the IBD milieu, their role is twofold. On the one hand, monocytes are instrumental in precipitating the disease’s progression. On the other hand, their differentiated offsprings, namely moM\u03c6s and moDCs, are conspicuously mobilized at inflammatory foci, manifesting either pro-inflammatory or anti-inflammatory actions. The phenotypic spectrum of these effector cells, intriguingly, is modulated by variables such as host genetics and the subtleties of the prevailing inflammatory microenvironment. Notwithstanding their significance, a palpable dearth exists in the literature concerning the roles and mechanisms of monocytes in IBD pathogenesis. This review endeavors to bridge this knowledge gap. It offers an exhaustive exploration of monocytes’ origin, their developmental trajectory, and their differentiation dynamics during IBD. Furthermore, it delves into the functional ramifications of monocytes and their differentiated progenies throughout IBD’s course. Through this lens, we aspire to furnish novel perspectives into IBD’s etiology and potential therapeutic strategies.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Xiping Liao\u00a0#\u00a01\u00a02,\u00a0Ji Liu\u00a0#\u00a03,\u00a0Xiaolong Guo\u00a01,\u00a0Ruiping Meng\u00a01,\u00a0Wei Zhang\u00a01,\u00a0Jianyun Zhou\u00a01,\u00a0Xia Xie\u00a01\u00a02,\u00a0Hongli Zhou\u00a01 J Inflamm Res.\u00a02024 May 13:17:2897-2914.\u00a0doi: 10.2147\/JIR.S450801.\u00a0eCollection 2024. Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic disease resulting from the interaction of various factors such as social elements, autoimmunity, genetics, and gut microbiota. Alarmingly, recent epidemiological data points to a […]<\/p>\n","protected":false},"template":"","scientific_tags":[424,426,312,667,107,830],"class_list":["post-11075","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-gma","scientific_tags-ibd","scientific_tags-immunology","scientific_tags-immunopathogenesis","scientific_tags-monocyte","scientific_tags-phenotypes"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/38764499\/<\/a>\r\n\r\nhttps:\/\/www.tandfonline.com\/doi\/full\/10.2147\/JIR.S450801#abstract<\/a>"},"yoast_head":"\nOrigin and Function of Monocytes in Inflammatory Bowel Disease - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/origin-and-function-of-monocytes-in-inflammatory-bowel-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Origin and Function of Monocytes in Inflammatory Bowel Disease - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Xiping Liao\u00a0#\u00a01\u00a02,\u00a0Ji Liu\u00a0#\u00a03,\u00a0Xiaolong Guo\u00a01,\u00a0Ruiping Meng\u00a01,\u00a0Wei Zhang\u00a01,\u00a0Jianyun Zhou\u00a01,\u00a0Xia Xie\u00a01\u00a02,\u00a0Hongli Zhou\u00a01 J Inflamm Res.\u00a02024 May 13:17:2897-2914.\u00a0doi: 10.2147\/JIR.S450801.\u00a0eCollection 2024. 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