{"id":11073,"date":"2024-11-27T13:44:00","date_gmt":"2024-11-27T12:44:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11073"},"modified":"2025-08-08T13:50:48","modified_gmt":"2025-08-08T11:50:48","slug":"repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/","title":{"rendered":"Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Franceschin+L&amp;cauthor_id=39766222\">Ludovica Franceschin<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Guidotti+A&amp;cauthor_id=39766222\">Alessia Guidotti<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Mazzetto+R&amp;cauthor_id=39766222\">Roberto Mazzetto<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Tartaglia+J&amp;cauthor_id=39766222\">Jacopo Tartaglia<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ciolfi+C&amp;cauthor_id=39766222\">Christian Ciolfi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Alaibac+M&amp;cauthor_id=39766222\">Mauro Alaibac<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sernicola+A&amp;cauthor_id=39766222\">Alvise Sernicola<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39766222\/#full-view-affiliation-1\">1<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Biomolecules.\u00a02024 Nov 27;14(12):1515.\u00a0doi: 10.3390\/biom14121515.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist&#8217;s therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic drugs have established themselves as versatile agents in the treatment of a wide range of dermatological conditions. Some of these agents are approved for the management of specific dermatologic conditions, but most of their current uses are off-label and only supported by isolated reports or case series. Their anti-inflammatory and immunomodulatory properties make them particularly valuable in managing auto-immune bullous diseases, neutrophilic dermatoses, eosinophilic dermatoses, interface dermatitis, and granulomatous diseases that are the focus of this review. By inhibiting inflammatory pathways, reducing cytokine production, and modulating immune responses, they contribute significantly to the treatment and management of these complex skin conditions. Their use continues to evolve as our understanding of these diseases deepens, and they remain a cornerstone of dermatological therapy.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>GMA is a promising alternative in patients who have failed conventional therapies for generalized pustular psoriasis, pyoderma gangrenosum, Beh\u00e7et\u2019s disease, and hidradenitis suppurativa. The strengths of GMA lie in its favorable tolerability and peculiar mode of action that is able to deplete inflammation without causing immunodeficiency.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Ludovica Franceschin\u00a01,\u00a0Alessia Guidotti\u00a01,\u00a0Roberto Mazzetto\u00a01,\u00a0Jacopo Tartaglia\u00a01,\u00a0Christian Ciolfi\u00a01,\u00a0Mauro Alaibac\u00a01,\u00a0Alvise Sernicola\u00a01 Biomolecules.\u00a02024 Nov 27;14(12):1515.\u00a0doi: 10.3390\/biom14121515. Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist&#8217;s therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[894,203,895,896,348,424,173,445,154,196,115,461,156,128,615],"class_list":["post-11073","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-autoimmune-bullous-disorders","scientific_tags-behcets-disease","scientific_tags-colchicine","scientific_tags-dapsone","scientific_tags-generalized-pustular-psoriasis","scientific_tags-gma","scientific_tags-moa","scientific_tags-neutrophil","scientific_tags-neutrophilic-dermatoses","scientific_tags-psoriasis","scientific_tags-pyoderma-gangrenosum","scientific_tags-refractory","scientific_tags-safety","scientific_tags-suppurative-hidradenitis","scientific_tags-tolerability"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Ludovica Franceschin\u00a01,\u00a0Alessia Guidotti\u00a01,\u00a0Roberto Mazzetto\u00a01,\u00a0Jacopo Tartaglia\u00a01,\u00a0Christian Ciolfi\u00a01,\u00a0Mauro Alaibac\u00a01,\u00a0Alvise Sernicola\u00a01 Biomolecules.\u00a02024 Nov 27;14(12):1515.\u00a0doi: 10.3390\/biom14121515. Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist&#8217;s therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T11:50:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/\",\"name\":\"Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-11-27T12:44:00+00:00\",\"dateModified\":\"2025-08-08T11:50:48+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/repurposing-historic-drugs-for-neutrophil-mediated-inflammation-in-skin-disorders\/","og_locale":"es_ES","og_type":"article","og_title":"Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders - Adacyte","og_description":"Ludovica Franceschin\u00a01,\u00a0Alessia Guidotti\u00a01,\u00a0Roberto Mazzetto\u00a01,\u00a0Jacopo Tartaglia\u00a01,\u00a0Christian Ciolfi\u00a01,\u00a0Mauro Alaibac\u00a01,\u00a0Alvise Sernicola\u00a01 Biomolecules.\u00a02024 Nov 27;14(12):1515.\u00a0doi: 10.3390\/biom14121515. Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist&#8217;s therapeutic armamentarium that are credited with potent anti-neutrophilic effects. 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