{"id":11059,"date":"2025-03-25T11:28:00","date_gmt":"2025-03-25T10:28:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11059"},"modified":"2025-08-08T11:38:30","modified_gmt":"2025-08-08T09:38:30","slug":"oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/","title":{"rendered":"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Tawada+C&amp;cauthor_id=40062426\">Chisato Tawada<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ueda+Y&amp;cauthor_id=40062426\">Yoko Ueda<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Mizutani+Y&amp;cauthor_id=40062426\">Yoko Mizutani<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Zang+X&amp;cauthor_id=40062426\">Xiaoyu Zang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Tanaka+K&amp;cauthor_id=40062426\">Kayoko Tanaka<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Iwata+H&amp;cauthor_id=40062426\">Hiroaki Iwata<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/#full-view-affiliation-1\">1<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Exp Dermatol.\u00a02025 Mar;34(3):e70076.\u00a0doi: 10.1111\/exd.70076.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed the diacron-reactive oxygen metabolite (d-ROM) test and the biological antioxidant potential (BAP) test on sera from nine patients with active GPP who were hospitalised and treated at our hospital, (6\/9 with GMA) including three patients with pustular psoriasis of pregnancy (PPP). The serum d-ROM and BAP levels were evaluated before treatment and at 1 month of treatment. We also performed immunostaining of 4-hydroxy-2-nonenal (4-HNE) in skin tissues. In the GPP patients, the average d-ROM levels were significantly reduced at 1 month of treatment (reduced to 343.0 \u00b1 82.1 U.Carr from 423.2 \u00b1 95.0 U.Carr, p = 0.005). The Generalised Pustular Psoriasis Area and Severity Index (GPPASI) score correlated with d-ROM levels (r = 0.57, p = 0.10), suggesting that those levels reflect the disease severity. In normal pregnancy, d-ROM values are known to increase from mid-term to late-term. The d-ROM values increased when GPP worsened in the case of PPP. Immunohistochemical staining of 4-HNE was positive for subcorneal pustules, neutrophils, and for the cytoplasm of epidermal keratinocytes, especially in upper epidermal layers. Our findings indicate that 4-HNE may play an important role in GPP and PPP.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Chisato Tawada\u00a01,\u00a0Yoko Ueda\u00a02,\u00a0Yoko Mizutani\u00a01,\u00a0Xiaoyu Zang\u00a01,\u00a0Kayoko Tanaka\u00a01,\u00a0Hiroaki Iwata\u00a01 Exp Dermatol.\u00a02025 Mar;34(3):e70076.\u00a0doi: 10.1111\/exd.70076. Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed the diacron-reactive oxygen metabolite (d-ROM) test and the biological antioxidant potential (BAP) test on sera from nine patients with active [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[348,424,72,461,879,527],"class_list":["post-11059","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-generalized-pustular-psoriasis","scientific_tags-gma","scientific_tags-pregnancy","scientific_tags-refractory","scientific_tags-ros","scientific_tags-steroid"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40062426\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40279047\/<\/a>\r\n\r\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12328-025-02126-x\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/exd.70076<\/a>\r\n\r\n&nbsp;"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Chisato Tawada\u00a01,\u00a0Yoko Ueda\u00a02,\u00a0Yoko Mizutani\u00a01,\u00a0Xiaoyu Zang\u00a01,\u00a0Kayoko Tanaka\u00a01,\u00a0Hiroaki Iwata\u00a01 Exp Dermatol.\u00a02025 Mar;34(3):e70076.\u00a0doi: 10.1111\/exd.70076. Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed the diacron-reactive oxygen metabolite (d-ROM) test and the biological antioxidant potential (BAP) test on sera from nine patients with active [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T09:38:30+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/\",\"name\":\"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2025-03-25T10:28:00+00:00\",\"dateModified\":\"2025-08-08T09:38:30+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/","og_locale":"es_ES","og_type":"article","og_title":"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte","og_description":"Chisato Tawada\u00a01,\u00a0Yoko Ueda\u00a02,\u00a0Yoko Mizutani\u00a01,\u00a0Xiaoyu Zang\u00a01,\u00a0Kayoko Tanaka\u00a01,\u00a0Hiroaki Iwata\u00a01 Exp Dermatol.\u00a02025 Mar;34(3):e70076.\u00a0doi: 10.1111\/exd.70076. Reactive oxygen species (ROS) are involved in the pathogenesis of generalised pustular psoriasis (GPP), but this involvement has not been fully elucidated. We performed the diacron-reactive oxygen metabolite (d-ROM) test and the biological antioxidant potential (BAP) test on sera from nine patients with active [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/","og_site_name":"Adacyte","article_modified_time":"2025-08-08T09:38:30+00:00","twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/","name":"Oxidative Stress and Generalised Pustular Psoriasis: Report of d-ROM Measurements in Nine Cases Including Three of Pustular Psoriasis of Pregnancy - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2025-03-25T10:28:00+00:00","dateModified":"2025-08-08T09:38:30+00:00","inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/oxidative-stress-and-generalised-pustular-psoriasis-report-of-d-rom-measurements-in-nine-cases-including-three-of-pustular-psoriasis-of-pregnancy\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner\/11059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/media?parent=11059"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/es\/wp-json\/wp\/v2\/scientific_tags?post=11059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}