{"id":11020,"date":"2025-06-03T16:16:00","date_gmt":"2025-06-03T14:16:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11020"},"modified":"2025-08-07T16:19:40","modified_gmt":"2025-08-07T14:19:40","slug":"granulocyte-and-monocyte-adsorptive-apheresis-maintenance-therapy-restored-the-loss-of-response-to-anti-tnf-alpha-agents-in-the-patients-with-uc-a-case-report","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-maintenance-therapy-restored-the-loss-of-response-to-anti-tnf-alpha-agents-in-the-patients-with-uc-a-case-report\/","title":{"rendered":"Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti-TNF-Alpha Agents in the Patients With UC: A Case Report"},"content":{"rendered":"
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Nobuhiro Ueno<\/a>\u00a01<\/a>\u00a02<\/a><\/sup>,\u00a0Yu Kobayashi<\/a>\u00a03<\/a><\/sup>,\u00a0Aki Sakatani<\/a>\u00a02<\/a><\/sup>,\u00a0Tatsuya Dokoshi<\/a>\u00a03<\/a><\/sup>,\u00a0Keitaro Takahashi<\/a>\u00a03<\/a><\/sup>,\u00a0Katsuyoshi Ando<\/a>\u00a03<\/a><\/sup>,\u00a0Shin Kashima<\/a>\u00a03<\/a><\/sup>,\u00a0Kentaro Moriichi<\/a>\u00a03<\/a><\/sup>,\u00a0Hiroki Tanabe<\/a>\u00a03<\/a><\/sup>,\u00a0Yuki Kamikokura<\/a>\u00a04<\/a><\/sup>,\u00a0Mishie Tanino<\/a>\u00a04<\/a><\/sup>,\u00a0Mikihiro Fujiya<\/a>\u00a02<\/a>\u00a0<\/sup><\/p>\n<\/div>\n\n

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J Clin Apher. 2025 Jun;40(3):e70030.\u00a0doi: 10.1002\/jca.70030.<\/p>\n<\/div>\n\n

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Ulcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti-tumor necrosis factor \u03b1 (anti-TNF-\u03b1) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due to anti-drug antibodies, poses a significant therapeutic challenge. This report describes a case where granulocyte and monocyte adsorptive apheresis (GMA) maintenance therapy successfully restored the efficacy of an anti-TNF-\u03b1 agent in a 26-year-old male with active UC experiencing LOR to infliximab. Following GMA induction therapy and continued infliximab administration, clinical symptoms improved, fecal calprotectin levels decreased, and clinical remission was achieved. Long-term maintenance with GMA enabled sustained clinical remission, with mucosal healing observed one year post-therapy. This case suggests that GMA maintenance therapy may serve as a novel therapeutic approach for patients with active UC experiencing LOR to anti-TNF-\u03b1 agents. However, further studies are warranted to elucidate the underlying mechanisms and validate its efficacy.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Nobuhiro Ueno\u00a01\u00a02,\u00a0Yu Kobayashi\u00a03,\u00a0Aki Sakatani\u00a02,\u00a0Tatsuya Dokoshi\u00a03,\u00a0Keitaro Takahashi\u00a03,\u00a0Katsuyoshi Ando\u00a03,\u00a0Shin Kashima\u00a03,\u00a0Kentaro Moriichi\u00a03,\u00a0Hiroki Tanabe\u00a03,\u00a0Yuki Kamikokura\u00a04,\u00a0Mishie Tanino\u00a04,\u00a0Mikihiro Fujiya\u00a02\u00a0 J Clin Apher. 2025 Jun;40(3):e70030.\u00a0doi: 10.1002\/jca.70030. Ulcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti-tumor necrosis factor \u03b1 (anti-TNF-\u03b1) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due to anti-drug antibodies, […]<\/p>\n","protected":false},"template":"","scientific_tags":[70,728,147,157,654,424,435,91,308,843,306],"class_list":["post-11020","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-anti-tnf","scientific_tags-case-report","scientific_tags-clinical-remission","scientific_tags-efficacy","scientific_tags-fecal-calprotectin","scientific_tags-gma","scientific_tags-lor","scientific_tags-maintenance","scientific_tags-mucosal-healing","scientific_tags-sustained-clinical-remission","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"\nGranulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti-TNF-Alpha Agents in the Patients With UC: A Case Report - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-maintenance-therapy-restored-the-loss-of-response-to-anti-tnf-alpha-agents-in-the-patients-with-uc-a-case-report\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti-TNF-Alpha Agents in the Patients With UC: A Case Report - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Nobuhiro Ueno\u00a01\u00a02,\u00a0Yu Kobayashi\u00a03,\u00a0Aki Sakatani\u00a02,\u00a0Tatsuya Dokoshi\u00a03,\u00a0Keitaro Takahashi\u00a03,\u00a0Katsuyoshi Ando\u00a03,\u00a0Shin Kashima\u00a03,\u00a0Kentaro Moriichi\u00a03,\u00a0Hiroki Tanabe\u00a03,\u00a0Yuki Kamikokura\u00a04,\u00a0Mishie Tanino\u00a04,\u00a0Mikihiro Fujiya\u00a02\u00a0 J Clin Apher. 2025 Jun;40(3):e70030.\u00a0doi: 10.1002\/jca.70030. Ulcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti-tumor necrosis factor \u03b1 (anti-TNF-\u03b1) agents often used for refractory cases. 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