{"id":11012,"date":"2024-11-06T13:24:00","date_gmt":"2024-11-06T12:24:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11012"},"modified":"2025-08-07T13:31:07","modified_gmt":"2025-08-07T11:31:07","slug":"granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-a-useful-therapeutic-tool-not-just-in-ulcerative-colitis-but-also-in-crohns-disease","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-a-useful-therapeutic-tool-not-just-in-ulcerative-colitis-but-also-in-crohns-disease\/","title":{"rendered":"Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: A useful therapeutic tool not just in ulcerative colitis but also in Crohn&#8217;s disease"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fern%C3%A1ndez-P%C3%A9rez+FJ&amp;cauthor_id=38710467\">Francisco Jos\u00e9 Fern\u00e1ndez-P\u00e9rez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fern%C3%A1ndez-Moreno+N&amp;cauthor_id=38710467\">Nuria Fern\u00e1ndez-Moreno<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Soria-L%C3%B3pez+E&amp;cauthor_id=38710467\">Estela Soria-L\u00f3pez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rodriguez-Gonz%C3%A1lez+FJ&amp;cauthor_id=38710467\">Francisco Javier Rodriguez-Gonz\u00e1lez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fern%C3%A1ndez-Galeote+FJ&amp;cauthor_id=38710467\">Francisco Jos\u00e9 Fern\u00e1ndez-Galeote<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lifante-Oliva+A&amp;cauthor_id=38710467\">Ana Lifante-Oliva<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ru%C3%ADz-Hern%C3%A1ndez+C&amp;cauthor_id=38710467\">Concepci\u00f3n Ru\u00edz-Hern\u00e1ndez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Escalante-Quijaite+E&amp;cauthor_id=38710467\">Elisabeth Escalante-Quijaite<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rivas-Ruiz+F&amp;cauthor_id=38710467\">Francisco Rivas-Ruiz<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/#full-view-affiliation-5\">5<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Gastroenterol Hepatol.\u00a02024 Nov;47(9):502196.\u00a0doi: 10.1016\/j.gastrohep.2024.502196.\u00a0Epub 2024 May 6. (Article in Spanish)<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Introduction:&nbsp;<\/strong>Granulocyte and monocyte adsorptive apheresis (GMA) removes neutrophils and monocytes from peripheral blood, preventing their incorporation into the inflamed tissue also influencing cytokine balance. Published therapeutic efficacy in ulcerative colitis (UC) is more consistent than in Crohn&#8217;s disease (CD). We assessed clinical efficacy of GMA in UC and CD 4 weeks after last induction session, at 3 and 12 months, sustained remission and corticosteroid-free remission.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Patients and method:&nbsp;<\/strong>Retrospective observational study of UC and CD patients treated with GMA. Partial Disease Activity Index-DAIp in UC and Harvey-Bradshaw Index-HBI in CD assessed efficacy of Adacolumn\u00ae with induction and optional maintenance sessions.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Results:&nbsp;<\/strong>We treated 87 patients (CD-25, UC-62), 87.3% corticosteroid-dependent (CSD), 42.5% refractory\/intolerant to immunomodulators. In UC, remission and response were 32.2% and 19.3% after induction, 35.5% and 6.5% at 12 weeks and 29% and 6.5% at 52 weeks. In CD, remission rates were 60%, 52% and 40% respectively. In corticosteroid-dependent and refractory or intolerant to INM patients (UC-41, CD-14), 68.3% of UC achieved remission or response after induction, 51.2% at 12 weeks and 46.3% at 52 weeks, and 62.3%, 64.3% and 42.9% in CD. Maintained remission was achieved by 66.6% in CD and 53.1% in UC. Up to 74.5% of patients required corticosteroids at some timepoint. Corticosteroid-free response\/remission was 17.7% in UC and 24% in CD.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Conclusions:&nbsp;<\/strong>GMA is a good therapeutic tool for both in UC and CD patients. In corticosteroid-dependent and refractory or intolerant to INM patients it avoids biological therapy or surgery in up to 40% of them in one year.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Francisco Jos\u00e9 Fern\u00e1ndez-P\u00e9rez\u00a01,\u00a0Nuria Fern\u00e1ndez-Moreno\u00a02,\u00a0Estela Soria-L\u00f3pez\u00a02,\u00a0Francisco Javier Rodriguez-Gonz\u00e1lez\u00a02,\u00a0Francisco Jos\u00e9 Fern\u00e1ndez-Galeote\u00a03,\u00a0Ana Lifante-Oliva\u00a04,\u00a0Concepci\u00f3n Ru\u00edz-Hern\u00e1ndez\u00a04,\u00a0Elisabeth Escalante-Quijaite\u00a04,\u00a0Francisco Rivas-Ruiz\u00a05 Gastroenterol Hepatol.\u00a02024 Nov;47(9):502196.\u00a0doi: 10.1016\/j.gastrohep.2024.502196.\u00a0Epub 2024 May 6. (Article in Spanish) Introduction:&nbsp;Granulocyte and monocyte adsorptive apheresis (GMA) removes neutrophils and monocytes from peripheral blood, preventing their incorporation into the inflamed tissue also influencing cytokine balance. Published therapeutic efficacy in ulcerative colitis (UC) is [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[159,157,424,426,65,98,844,269,461,305,156,603,309,271,843,306],"class_list":["post-11012","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-crohns-disease","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-ibd","scientific_tags-immunosuppressant","scientific_tags-immunosuppressant-refractory","scientific_tags-intolerant","scientific_tags-observational","scientific_tags-refractory","scientific_tags-retrsopective","scientific_tags-safety","scientific_tags-steroid-dependent-2","scientific_tags-steroid-free","scientific_tags-study","scientific_tags-sustained-clinical-remission","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710467\/\">Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: A useful therapeutic tool not just in ulcerative colitis but also in Crohn's disease - PubMed<\/a>\r\n\r\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0210570524001547\">Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: A useful therapeutic tool not just in ulcerative colitis but also in Crohn's disease - ScienceDirect<\/a>\r\n\r\n&nbsp;"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: A useful therapeutic tool not just in ulcerative colitis but also in Crohn&#039;s disease - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-gma-in-patients-with-inflammatory-bowel-disease-a-useful-therapeutic-tool-not-just-in-ulcerative-colitis-but-also-in-crohns-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: A useful therapeutic tool not just in ulcerative colitis but also in Crohn&#039;s disease - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Francisco Jos\u00e9 Fern\u00e1ndez-P\u00e9rez\u00a01,\u00a0Nuria Fern\u00e1ndez-Moreno\u00a02,\u00a0Estela Soria-L\u00f3pez\u00a02,\u00a0Francisco Javier Rodriguez-Gonz\u00e1lez\u00a02,\u00a0Francisco Jos\u00e9 Fern\u00e1ndez-Galeote\u00a03,\u00a0Ana Lifante-Oliva\u00a04,\u00a0Concepci\u00f3n Ru\u00edz-Hern\u00e1ndez\u00a04,\u00a0Elisabeth Escalante-Quijaite\u00a04,\u00a0Francisco Rivas-Ruiz\u00a05 Gastroenterol Hepatol.\u00a02024 Nov;47(9):502196.\u00a0doi: 10.1016\/j.gastrohep.2024.502196.\u00a0Epub 2024 May 6. (Article in Spanish) Introduction:&nbsp;Granulocyte and monocyte adsorptive apheresis (GMA) removes neutrophils and monocytes from peripheral blood, preventing their incorporation into the inflamed tissue also influencing cytokine balance. 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