{"id":11003,"date":"2024-01-07T11:57:00","date_gmt":"2024-01-07T10:57:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11003"},"modified":"2025-08-07T12:05:00","modified_gmt":"2025-08-07T10:05:00","slug":"dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/es\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/","title":{"rendered":"Dictionary of immune responses to cytokines at single-cell resolution"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Cui+A&amp;cauthor_id=38057668\">Ang Cui<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-1\">1<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-2\">2<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Huang+T&amp;cauthor_id=38057668\">Teddy Huang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Li+S&amp;cauthor_id=38057668\">Shuqiang Li<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ma+A&amp;cauthor_id=38057668\">Aileen Ma<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=P%C3%A9rez+JL&amp;cauthor_id=38057668\">Jorge L P\u00e9rez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sander+C&amp;cauthor_id=38057668\">Chris Sander<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-7\">7<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-8\">8<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Keskin+DB&amp;cauthor_id=38057668\">Derin B Keskin<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-4\">4<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-9\">9<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Wu+CJ&amp;cauthor_id=38057668\">Catherine J Wu<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-9\">9<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-10\">10<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Fraenkel+E&amp;cauthor_id=38057668\">Ernest Fraenkel<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-5\">5<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-11\">11<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Hacohen+N&amp;cauthor_id=38057668\">Nir Hacohen<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-12\">12<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-13\">13<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/#full-view-affiliation-14\">14<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Nature 2024 Jan;625(7994):377-384.\u00a0doi: 10.1038\/s41586-023-06816-9.\u00a0Epub 2023 Dec 6.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets<sup>1-3<\/sup>. A myriad of studies have highlighted their central role in immune function<sup>4-13<\/sup>, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, we created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1\u03b2 induces distinct gene programmes in almost every cell type. A cell-type-centric view of the dictionary identified more than 66 cytokine-driven cellular polarization states across immune cell types, including previously uncharacterized states such as an interleukin-18-induced polyfunctional natural killer cell state. Based on this dictionary, we developed companion software, Immune Response Enrichment Analysis, for assessing cytokine activities and immune cell polarization from gene expression data, and applied it to reveal cytokine networks in tumours following immune checkpoint blockade therapy. Our dictionary generates new hypotheses for cytokine functions, illuminates pleiotropic effects of cytokines, expands our knowledge of activation states of each immune cell type, and provides a framework to deduce the roles of specific cytokines and cell-cell communication networks in any immune response.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=%22Nature%22%5Bjour%5D&amp;sort_order=desc\"><\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Ang Cui\u00a01\u00a02\u00a03,\u00a0Teddy Huang\u00a04,\u00a0Shuqiang Li\u00a05\u00a04,\u00a0Aileen Ma\u00a05\u00a06,\u00a0Jorge L P\u00e9rez\u00a05\u00a06,\u00a0Chris Sander\u00a05\u00a07\u00a08,\u00a0Derin B Keskin\u00a05\u00a04\u00a09,\u00a0Catherine J Wu\u00a05\u00a09\u00a010,\u00a0Ernest Fraenkel\u00a05\u00a011,\u00a0Nir Hacohen\u00a012\u00a013\u00a014 Nature 2024 Jan;625(7994):377-384.\u00a0doi: 10.1038\/s41586-023-06816-9.\u00a0Epub 2023 Dec 6. Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets1-3. A myriad of studies have highlighted their central role in immune function4-13, yet we lack a global view of the cellular [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[826,824,79,823,822,691,318,795,744,825],"class_list":["post-11003","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cell-cell-communication-network","scientific_tags-companion-software","scientific_tags-cytokines","scientific_tags-dictionary","scientific_tags-immune","scientific_tags-immune-checkpoint-inhibitors","scientific_tags-oncology","scientific_tags-single-cell","scientific_tags-transcriptomics","scientific_tags-tumour"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38057668\/\">Dictionary of immune responses to cytokines at single-cell resolution - PubMed<\/a>\r\n\r\n<a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06816-9\">Dictionary of immune responses to cytokines at single-cell resolution | Nature<\/a>\r\n\r\n&nbsp;"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dictionary of immune responses to cytokines at single-cell resolution - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dictionary of immune responses to cytokines at single-cell resolution - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Ang Cui\u00a01\u00a02\u00a03,\u00a0Teddy Huang\u00a04,\u00a0Shuqiang Li\u00a05\u00a04,\u00a0Aileen Ma\u00a05\u00a06,\u00a0Jorge L P\u00e9rez\u00a05\u00a06,\u00a0Chris Sander\u00a05\u00a07\u00a08,\u00a0Derin B Keskin\u00a05\u00a04\u00a09,\u00a0Catherine J Wu\u00a05\u00a09\u00a010,\u00a0Ernest Fraenkel\u00a05\u00a011,\u00a0Nir Hacohen\u00a012\u00a013\u00a014 Nature 2024 Jan;625(7994):377-384.\u00a0doi: 10.1038\/s41586-023-06816-9.\u00a0Epub 2023 Dec 6. Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets1-3. A myriad of studies have highlighted their central role in immune function4-13, yet we lack a global view of the cellular [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-07T10:05:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/\",\"name\":\"Dictionary of immune responses to cytokines at single-cell resolution - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-07T10:57:00+00:00\",\"dateModified\":\"2025-08-07T10:05:00+00:00\",\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dictionary of immune responses to cytokines at single-cell resolution - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dictionary-of-immune-responses-to-cytokines-at-single-cell-resolution\/","og_locale":"es_ES","og_type":"article","og_title":"Dictionary of immune responses to cytokines at single-cell resolution - Adacyte","og_description":"Ang Cui\u00a01\u00a02\u00a03,\u00a0Teddy Huang\u00a04,\u00a0Shuqiang Li\u00a05\u00a04,\u00a0Aileen Ma\u00a05\u00a06,\u00a0Jorge L P\u00e9rez\u00a05\u00a06,\u00a0Chris Sander\u00a05\u00a07\u00a08,\u00a0Derin B Keskin\u00a05\u00a04\u00a09,\u00a0Catherine J Wu\u00a05\u00a09\u00a010,\u00a0Ernest Fraenkel\u00a05\u00a011,\u00a0Nir Hacohen\u00a012\u00a013\u00a014 Nature 2024 Jan;625(7994):377-384.\u00a0doi: 10.1038\/s41586-023-06816-9.\u00a0Epub 2023 Dec 6. Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets1-3. 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