{"id":5614,"date":"2021-03-16T11:40:01","date_gmt":"2021-03-16T11:40:01","guid":{"rendered":"https:\/\/www.adacyte.com\/professional\/products\/adacolumn\/"},"modified":"2024-02-07T03:46:31","modified_gmt":"2024-02-07T02:46:31","slug":"adacolumn_","status":"publish","type":"professional_product","link":"https:\/\/www.adacyte.com\/es\/professional\/products\/adacolumn_\/","title":{"rendered":"Adacolumn\u00ae"},"content":{"rendered":"<div class=\"relative max-h-768 overflow-hidden mb-0\">\n  <div class=\"absolute w-full h-full max-w-mw px-25 pb-65 flex flex-col justify-end md:left-50% md:transform md:-translate-x-50% xl:px-0 lg:pt-120 xl:pt-180\">\n    <div class=\"pb-65 lg:pb-100\">\n      <h1 class=\"text-white font-display font-bold text-36-40 uppercase mb-35 lg:text-60-70 lg:max-w-710 lg:mb-40\">Adacolumn\u00ae<\/h1>\n            <div class=\"font-body text-18-24 text-white lg:text-22-30 lg:max-w-710\">\n        <p>La granulocito y monocito af\u00e9resis (GMA) act\u00faa espec\u00edficamente evitando la migraci\u00f3n de granulocitos (neutr\u00f3filos) y monocitos activados hacia la pared gastrointestinal.<\/p>\n      <\/div>\n          <\/div>\n  <\/div>\n  <picture>\n    <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/product-hero-d@2x.jpg\" \/>\n    <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/product-hero-m@2x.jpg\" alt=\"\" title=\"product-hero-d@2x\">\n  <\/picture>\n<\/div>\n<div class=\"mb-0\">  <div id=\"product-navigation\" class=\"w-full bg-blue-d px-25 lg:px-45 mw:px-75 py-65 mw:py-80\">\n    <div class=\"w-full max-w-987 mx-auto lg:flex lg:justify-between\">\n  <ul class=\"lg:w-48%\"><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Mecanismo de acci\u00f3n del granulocito y monocito af\u00e9resis (GMA) en el tratamiento de la EII\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Mecanismo de acci\u00f3n del granulocito y monocito af\u00e9resis (GMA) en el tratamiento de la EII<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#role-of-granulocytes\" title=\"Funci\u00f3n de los granulocitos y monocitos en la EII\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Funci\u00f3n de los granulocitos y monocitos en la EII<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#adacolumn\" title=\"Granulocito y monocito af\u00e9resis (GMA): Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Granulocito y monocito af\u00e9resis (GMA): Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#video-adacolumn\" title=\"Video presentaci\u00f3n Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Video presentaci\u00f3n Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#video-moa\" title=\"V\u00eddeo MoA Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">V\u00eddeo MoA Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#gma-moa\" title=\"Mecanismo de acci\u00f3n de la GMA\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Mecanismo de acci\u00f3n de la GMA<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#approved-indications\" title=\"Indicaciones aprobadas\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Indicaciones aprobadas<\/a><\/li><\/ul><ul class=\"lg:w-48%\"><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#patient-material\" title=\"Materiales de informaci\u00f3n para pacientes de Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Materiales de informaci\u00f3n para pacientes de Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Informaci\u00f3n t\u00e9cnica y soporte de Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Informaci\u00f3n t\u00e9cnica y soporte de Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Evidencia cient\u00edfica\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Evidencia cient\u00edfica<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#rational-adacolumn-ibd\" title=\"Calculadora de tiempo de af\u00e9resis\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Calculadora de tiempo de af\u00e9resis<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#gma-safety\" title=\"Seguridad y contraindicaciones de la Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Seguridad y contraindicaciones de la Adacolumn\u00ae<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#in-summary\" title=\"En resumen\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">En resumen<\/a><\/li><li class=\"flex items-centerX svg-w-100 svg-fill-blue-l py-11\"><span class=\"mr-15 relative top-3\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"><\/path><\/svg><\/span><a href=\"#in-summary\" title=\"Instrucciones de uso de Adacolumn\u00ae\" class=\"product--subnav-link block font-display font-bold text-white text-16 lg:text-18-21 pt-20x\">Instrucciones de uso de Adacolumn\u00ae<\/a><\/li><\/ul>    <\/div>\n  <\/div>\n  <\/div>\n\n<div style=\"\n    width: 70%;\n\" class=\"relative overflow-hidden video-bg  mx-auto mb-65 lg:mb-115\" id=\"video-adacolumn\">\n    <div class=\"relative left-0 top-0 w-full overflow-hidden z-1\">\n    <div data-id=\"6a4c76d3250d9\" class=\"relative wp-block-embed__wrapper w-full vimeo-player vimeo-player-6a4c76d3250d9\">\n  \n    <iframe loading=\"lazy\" id=\"vimeo--iframe-6a4c76d3250d9\" src=\"https:\/\/player.vimeo.com\/video\/651676455?h=a0c356b991&amp;dnt=1&amp;app_id=122963\" width=\"640\" height=\"360\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><?h=iframe>\u00bb width=\u00bb640&#8243; height=\u00bb360&#8243; frameborder=\u00bb0&#8243; allow=\u00bbautoplay; fullscreen; picture-in-picture\u00bb allowfullscreen><\/iframe>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n\n\n\n\n<div class=\"max-w-mw mx-auto mb-85 lg:mb-200\" id=\"rational-adacolumn-ibd\">\n  <div class=\"flex flex-col lg:flex-row lg:justify-between\">\n\n    <div class=\"mb-75 w-full lg:mb-0 lg:max-w-430 lg:pt-75\">\n              <a href=\"https:\/\/www.adacyte.com\/es\/professional\/products\/adacolumn_\/asistencia-tecnica\/\" title=\"INFORMACI\u00d3N Y ASISTENCIA T\u00c9CNICA\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">INFORMACI\u00d3N Y ASISTENCIA T\u00c9CNICA<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n                <a href=\"https:\/\/www.adacyte.com\/es\/profesional\/tiempo-de-aferesis\/\" title=\"Tiempo de aferesis\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">Tiempo de aferesis<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n                <a href=\"https:\/\/www.adacyte.com\/es\/profesional\/evidencia-cientifica\/\" title=\"Evidencia cient\u00edfica\" class=\"flex w-full items-start bg-gray-light mb-15 lg:mb-20\">\n                    <div class=\"p-20 lg:p-25\">\n                        <p class=\"text-blue-d font-body text-18-21 text-20-20 uppercase\">Evidencia cient\u00edfica<\/p>\n            <span class=\"flex ml-15 w-30 pt-3 svg-fill-blue-l\"><svg height=\"19\" viewBox=\"0 0 38 19\" width=\"38\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m77.3493782 9.6081343 9.6001194 8.7394719c.23238.2077938.6295199.2092847.8532599.0241621.2274-.1881043.24408-.5334163.0282-.7310825l-8.6438395-7.87195085h34.612588c.33138 0 .6-.23015657.6-.51408659s-.26862-.51408658-.6-.51408658h-34.612588l8.6438395-7.87196623c.21606-.19766629.20274-.54601136-.0282-.73108253-.2307599-.18507117-.6020999-.18964654-.8532599.02416207l-9.6001194 8.73948734c-.22818.24059252-.16818.53547258 0 .70697187z\" fill=\"#fff\" transform=\"matrix(-1 0 0 1 114.6 0)\"\/><\/svg><\/span>\n          <\/div>\n        <\/a>\n            <\/div>\n\n    <div class=\"text-18-24 max-w-586 font-body text-blue-d lg:text-18-28 lg:mr-45\">\n      <h2 class=\"font-display text-blue-l text-36-42 mb-45 lg:mb-70 lg:text-36-42\">Mecanismo de acci\u00f3n de la granulocito y monocito af\u00e9resis (GMA) en el tratamiento de la EII<\/h2>\n      <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28\">\n        <p class=\"p1\">En cualquier enfermedad mediada por el sistema inmunitario existe un paso inicial e imprescindible para que se produzca la inflamaci\u00f3n de los \u00f3rganos afectados: el reclutamiento de c\u00e9lulas inflamatorias del torrente circulatorio a los tejidos inflamados.<\/p>\n<p class=\"p1\">Una vez all\u00ed, estas c\u00e9lulas inflamatorias segregan diversas sustancias cuya funci\u00f3n ser\u00e1, por una parte, la de reclutar m\u00e1s c\u00e9lulas inflamatorias y, por otra, la de causar el da\u00f1o tisular propio de cada enfermedad.<\/p>\n<p class=\"p1\">Inicialmente, el tratamiento utilizado en las enfermedades mediadas por el sistema inmunitario se basaba en la administraci\u00f3n de corticoides e inmunosupresores no selectivos, cuyo mecanismo de acci\u00f3n afectaba a diversos niveles y presentaban una elevada tasa de efectos adversos.<\/p>\n<p class=\"p1\">En las \u00faltimas dos d\u00e9cadas, el tratamiento de estas enfermedades ha evolucionado hacia el uso de tratamientos mucho m\u00e1s selectivos y, por tanto, de efectos tanto terap\u00e9uticos como adversos m\u00e1s previsibles.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n  <div class=\"max-w-mw mx-auto mb-85 px-25 lg:px-0 lg:mb-200\" id=\"role-of-granulocytes\">\n          <h2 class=\"font-display text-blue-l text-36-42 max-w-944 mb-45 lg:mb-70 lg:text-36-42 lg:pl-157\">Funci\u00f3n de los granulocitos y monocitos en la EII<\/h2>\n        <div class=\"flex flex-col lg:flex-row\">\n              <picture class=\"order-2 lg:order-1 lg:mr-98 mb-85 block max-w-374 lg:w-57%\">\n          <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/05\/gobulos_blancos-1.jpg\" \/>\n          <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/05\/gobulos_blancos-1.jpg\" alt=\"\" title=\"gobulos_blancos\">\n        <\/picture>\n            <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28flex-col-reverse max-w-586 lg:order-2\">\n        <p class=\"p1\">En el caso de la enfermedad inflamatoria intestinal (EII), aunque otras c\u00e9lulas como los linfocitos y los monocitos tienen una funci\u00f3n determinada, la principal c\u00e9lula inflamatoria implicada en el mecanismo patog\u00e9nico es el neutr\u00f3filo, tambi\u00e9n llamado granulocito.<\/p>\n<p class=\"p1\">Los neutr\u00f3filos son reclutados activamente del torrente circulatorio a la capa mucosa del intestino, produciendo las lesiones propias de esta enfermedad mediante su desgranulaci\u00f3n y la liberaci\u00f3n de diversas proteinasas y quimiocinas.<\/p>\n<p class=\"p1\">De hecho, el protagonismo del neutr\u00f3filo en esta enfermedad es tal que diversos estudios han demostrado una espl\u00e9ndida relaci\u00f3n entre la presencia de neutr\u00f3filos en la pared gastrointestinal de los pacientes con EII y el riesgo de reca\u00edda cl\u00ednica (brote de la enfermedad) o de c\u00e1ncer de colon.<\/p>\n<p class=\"p1\">Otro hecho que demuestra la relevancia de la presencia de neutr\u00f3filos en la pared intestinal de los pacientes con EII es la utilidad de la calprotectina fecal para la predicci\u00f3n de reca\u00eddas o el diagn\u00f3stico de actividad de la enfermedad incluso en ausencia de s\u00edntomas. La calprotectina fecal es la principal prote\u00edna existente en el citoplasma de los neutr\u00f3filos y es detectable en heces siempre que la mucosa del tubo digestivo se halle infiltrada por estas c\u00e9lulas. Las caracter\u00edsticas fisicoqu\u00edmicas de esta prote\u00edna y su resistencia a la degradaci\u00f3n por parte de las bacterias del colon han permitido su uso en la pr\u00e1ctica cl\u00ednica, convirti\u00e9ndola en el par\u00e1metro m\u00e1s utilizado y fiable para el manejo y evaluaci\u00f3n de los pacientes con EII, en especial de aquellos con colitis ulcerosa.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div id=\"video-moa\"  class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"MoA Granulocyte Monocyte Adsorption Apheresis\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/kWtkZytgVUk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\"><em>MoA Granulocyte Monocyte Adsorption Apheresis<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n  <div class=\"max-w-mw mx-auto mb-85 px-25 lg:px-0 lg:mb-200\" id=\"adacolumn\">\n          <h2 class=\"font-display text-blue-l text-36-42 max-w-944 mb-45 lg:mb-70 lg:text-36-42 lg:pl-157\">Granulocito y monocito af\u00e9resis (GMA): Adacolumn\u00ae<\/h2>\n        <div class=\"flex flex-col lg:flex-row\">\n              <picture class=\"order-2 lg:order-1 lg:mr-98 mb-85 block max-w-374 lg:w-57%\">\n          <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/neutrofilos_monocitos.jpg\" \/>\n          <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/neutrofilos_monocitos.jpg\" alt=\"\" title=\"neutrofilos_monocitos\">\n        <\/picture>\n            <div class=\"post-content text-18-24 font-body text-blue-d lg:text-18-28flex-col-reverse max-w-586 lg:order-2\">\n        <p>La granulocito y monocito af\u00e9resis (GMA) act\u00faa espec\u00edficamente evitando la migraci\u00f3n de granulocitos (neutr\u00f3filos) y monocitos activados hacia la pared gastrointestinal (1). Se ha demostrado que las esferas de acetato de celulosa de <strong>Adacolumn\u00ae<\/strong> adsorben los inmunocomplejos e IgG circulantes adem\u00e1s de activar determinados fragmentos del complemento (en concreto C3a y C5a). Esto permite que el sistema adsorba de forma selectiva los granulocitos (por medio de los receptores Fc) y monocitos (por medio de los receptores del complemento).<\/p>\n<p>Adem\u00e1s de este efecto \u00abmec\u00e1nico\u00bb, se ha constatado que las esferas de acetato de celulosa son capaces de activar la apoptosis de los neutr\u00f3filos (que se halla reducida en la colitis ulcerosa). Se ha observado en diversos estudios que las esferas de acetato de celulosa y la presencia de cuerpos apopt\u00f3ticos de los neutr\u00f3filos incrementan la s\u00edntesis de citocinas antiinflamatorias (IL-10, IL-1ra, HGF) y consiguen la reducci\u00f3n de citocinas proinflamatorias (TNF-\u03b1, IL-6, IL-8, IL-1\u03b2) (2).<\/p>\n<p>Debido a la movilizaci\u00f3n de leucocitos desde la m\u00e9dula \u00f3sea, esta \u00abretirada\u00bb de neutr\u00f3filos y monocitos activados del torrente circulatorio no viene seguida de una reducci\u00f3n en el n\u00famero total de estas c\u00e9lulas en la sangre, pues estas son sustituidas por c\u00e9lulas inmaduras o inactivas.<\/p>\n<p>Esto explicar\u00eda por qu\u00e9 esta aplicaci\u00f3n de la GMA no va acompa\u00f1ada de un incremento en el riesgo de infecciones o tumores, que s\u00ed se constata con la mayor\u00eda de f\u00e1rmacos inmunosupresores (1). <small>1.- <span style=\"color: #3ab0c8;\">Hanai H1, Takeda Y, Eberhardson M, Gruber R, Saniabadi AR, Winqvist O, Lofberg R.<\/span> <strong>The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review<\/strong>, <span style=\"color: #3ab0c8;\">Clin Exp Immunol<\/span>. <strong>2011 Jan;163(1):50-8.DOI: 10.1111\/j.1365-2249.2010.04279.x. 2.-<\/strong> <span style=\"color: #3ab0c8;\">Saniabadi AR1, Hanai H, Takeuchi K, Umemura K, Nakashima M, Adachi T, Shima C, Bjarnason I, Lofberg R<\/span>. <strong>Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes.<\/strong> <span style=\"color: #3ab0c8;\">Ther Apher Dial<\/span>. <strong>2003 Feb;7(1):48-59. DOI:<\/strong><span style=\"color: #3ab0c8;\">10.1046\/j.1526-0968.2003.00012.x<\/span><\/small><\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n  <div class=\"relative\">\n    <picture class=\" max-w-200 lg:max-w-374 lg:w-57% lg:mr-98 lg:pt-50\">\n      <source media=\"(min-width: 768px)\" srcset=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/blood-cells-color-d@2x.jpg\" \/>\n      <img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/blood-cells-color-m@2x.jpg\" alt=\"\" title=\"blood-cells-color-d@2x\">\n    <\/picture>\n  <\/div>\n\n\n  <div class=\"max-w-mw mx-auto px-25 mb-85 pt-55 lg:px-0 lg:mb-200\" id=\"gma-moa\">\n        <p class=\"text-18-40 text-blue-l font-body lg:text-15-20\">VISI\u00d3N GENERAL<\/p>\n    \n        <h2 class=\"text-36-40 text-blue-d font-display uppercase font-bold max-w-400 lg:text-40-47\">Mecanismo de acci\u00f3n de la GMA(1)<\/h2>\n    \n    <div class=\"relative flex flex-col items-center md:justify-center\">\n      <img decoding=\"async\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/adacolum-product@2x.png\" alt=\"\" title=\"adacolum-product@2x\" class=\"max-w-1\/2 mb-45 lg:max-w-232\">\n              <ul class=\"lg:absolute lg:left-0 lg:top-0 lg:w-full\">\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-37 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-01@2x.png\" alt=\"\" title=\"gma-01@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Activaci\u00f3n de fragmentos del complemento (C3a, C5a).<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:left-50% lg:top-120 lg:-translate-x-430\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-02@2x.png\" alt=\"\" title=\"gma-02@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Adsorci\u00f3n de IgG e inmunocomplejos circulantes por las esferas de acetato de celulosa.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-160 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-03@2x.png\" alt=\"\" title=\"gma-03@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Adsorci\u00f3n de granulocitos y monocitos a trav\u00e9s de (1) los receptores Fc (IgC e IC), y (2) los sitios de uni\u00f3n de los receptores del complemento en los leucocitos (no as\u00ed en los linfocitos).<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:transform lg:left-50% lg:top-258 lg:-translate-x-430\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-04@2x.png\" alt=\"\" title=\"gma-04@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Reducci\u00f3n de neutr\u00f3filos y monocitos activados.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-290 lg:translate-x-40\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-05@2x.png\" alt=\"\" title=\"gma-05@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Las c\u00e9lulas apopt\u00f3ticas interact\u00faan con los linfocitos B reguladores, produciendo IL-10 y linfocitos B reguladores maduros.<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform flex-row-reverse lg:left-50% lg:top-365 lg:-translate-x-465\">\n            <span class=\"min-w-65 max-w-65 ml-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-06@2x-1.png\" alt=\"\" title=\"gma-06@2x\"><\/span>\n            <span class=\"text-15-20 text-right lg:max-w-315\">Retorno de las sustancias liberadas por las c\u00e9lulas adsorbidas: IL-1ra (control de la inflamaci\u00f3n intestinal) y HGF (regeneraci\u00f3n epitelial de la mucosa).<\/span>\n          <\/li>\n                  <li id=\"adacolum-item\" class=\"flex items-center font-body font-bold text-color-d mb-45 lg:absolute lg:transform lg:left-50% lg:top-435 lg:-translate-x-30\">\n            <span class=\"min-w-65 max-w-65 mr-15\"><img decoding=\"async\" class=\"w-full\" src=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/02\/gma-07@2x.png\" alt=\"\" title=\"gma-07@2x\"><\/span>\n            <span class=\"text-15-20 lg:max-w-315 lg:ml-50\">Generaci\u00f3n de c\u00e9lulas apopt\u00f3ticas (CA), en su mayor\u00eda neutr\u00f3filos, que en m\u00e1s del 40% regresan al torrente circulatorio del paciente.<\/span>\n          <\/li>\n                <\/ul>\n          <\/div>\n  <\/div>\n\n\n<div class=\"max-w-987 mx-auto mb-85 px-20 lg:px-0 md:flex md:flex-wrap md:justify-between pt-65 lg:pt-100 lg:mb-200\" id=\"ms-acerca-del-mecanismo-de-accin-de-adacolumn\">\n\n      <p class=\"text-blue-d font-display font-bold text-28-33 mb-45 md:mb-75\">M\u00c1S ACERCA DEL MECANISMO DE ACCI\u00d3N DE ADACOLUMN\u00ae<\/p>\n    \n    <ul class=\"w-full md:flex md:flex-wrap md:justify-between\">\n\n          <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-0920031-ADACOLUMN-MoA-BROCHURE-ENGLISH.pdf\" target=\"_blank\" title=\"Mecanismo de acci\u00f3n de Adacolumn\u00ae: inmunofisiolog\u00eda y comentarios de expertos (vol.I)\">Mecanismo de acci\u00f3n de Adacolumn\u00ae: inmunofisiolog\u00eda y comentarios de expertos (vol.I)<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n            <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-0920031A-ADACOLUMN-MOA-BROCHURE-ENGLISH-BAMIAS-JOANA-TORRES-1.pdf\" target=\"_blank\" title=\"Mecanismo de acci\u00f3n de Adacolumn\u00ae: inmunofisiolog\u00eda y comentarios de expertos (vol.II)\">Mecanismo de acci\u00f3n de Adacolumn\u00ae: inmunofisiolog\u00eda y comentarios de expertos (vol.II)<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n          <\/ul>\n    <\/div>\n\n\n<div class=\"block--cols-manually bg-white\" id=\"approved-indications\">\n\n  <div class=\"max-w-1366 mx-auto px-25 lg:px-75 py-65 lg:py-100\">\n\n        <div class=\"lg:flex lg:justify-between\">\n      <h2 class=\"lg:w-48% lg:max-w-586 font-display text-blue-l text-30-35 mb-45 lg:text-36-42\">Indicaciones aprobadas<\/h2>\n    <\/div>\n    \n    <div class=\"block--cols-manually-content  lg:flex lg:justify-between\">\n      <div class=\"lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28\">\n        <p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Adacolumn<sup>\u00ae<\/sup> es un producto sanitario aprobado para:<\/p>\n<ul>\n<li>Inducir la remisi\u00f3n en pacientes con enfermedad inflamatoria intestinal (colitis ulcerosa activa y enfermedad de Crohn).<\/li>\n<li>inhibir los s\u00edntomas subjetivos y objetivos de la artritis reumatoide en fase inflamatoria cuyos s\u00edntomas podr\u00edan ser resistentes al tratamiento farmacol\u00f3gico habitual.<\/li>\n<li>El tratamiento de pacientes con enfermedad de Beh\u00e7et ocular.<\/li>\n<li>El tratamiento de pacientes con lupus eritematoso sist\u00e9mico (LES).<\/li>\n<li>Mejorar los s\u00edntomas cl\u00ednicos de la psoriasis pustulosa (PP).<\/li>\n<\/ul>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Certificado CE: marcado CE 0123 por T\u00dcV S\u00dcD, clase de riesgo IIb.<\/p>\n      <\/div>\n\n      <div class=\"block--cols-manually-content lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28 pt-25 lg:pt-0\">\n              <\/div>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"block--cols-manually bg-white\" id=\"gma-safety\">\n\n  <div class=\"max-w-1366 mx-auto px-25 lg:px-75 py-65 lg:py-100\">\n\n        <div class=\"lg:flex lg:justify-between\">\n      <h2 class=\"lg:w-48% lg:max-w-586 font-display text-blue-l text-30-35 mb-45 lg:text-36-42\">Seguridad y contraindicaciones de la GMA<\/h2>\n    <\/div>\n    \n    <div class=\"block--cols-manually-content  lg:flex lg:justify-between\">\n      <div class=\"lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28\">\n              <\/div>\n\n      <div class=\"block--cols-manually-content lg:w-48% lg:max-w-586 text-18-24 font-body text-blue-d lg:text-18-28 pt-25 lg:pt-0\">\n        <p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">La GMA es una t\u00e9cnica segura. Los efectos secundarios afectan a un bajo porcentaje de pacientes (entre el 1 y el 15%) y suelen ser leves y transitorios. Los m\u00e1s frecuentes son: dolor de cabeza, mareos, fatiga, dolor muscular, enrojecimiento facial, hipotensi\u00f3n, palpitaciones, etc.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Las contraindicaciones son escasas.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Este procedimiento no est\u00e1 indicado en pacientes al\u00e9rgicos a la heparina (utilizada para evitar la coagulaci\u00f3n de la sangre en el circuito) ni en aquellos con una cifra baja de plaquetas.<\/p>\n<p class=\"text-justify text-blue-d text-18-24 lg:text-18-28 font-body\">Adem\u00e1s, deben tomarse precauciones en los pacientes que tengan una cifra baja de gl\u00f3bulos blancos, anemia intensa, infecci\u00f3n, enfermedad card\u00edaca o renal grave, problemas de coagulaci\u00f3n de la sangre o deshidrataci\u00f3n.<\/p>\n      <\/div>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"bg-blue-l pt-45 pb-50 px-25 lg:py-85 lg:px-0\" id=\"in-summary\">\n  <div class=\"max-w-mw mx-auto lg:flex lg:justify-between lg:items-end\">\n    <div class=\"max-w-574\">\n      <p class=\"font-display font-bold text-blue-d uppercase mb-35 text-36-40 mb-45 lg:text-36-42\">En resumen:<\/p>\n      <div class=\"summary-content font-body text-white text-18-29\">\n        <p>Con la GMA se logra(1):<\/p>\n<p>\u2022 una reducci\u00f3n de neutr\u00f3filos y monocitos activados en el torrente circulatorio.<br \/>\n\u2022 un aumento de las citocinas antiinflamatorias.<br \/>\n\u2022 un descenso de las citocinas proinflamatorias.<\/p>\n<p>Esto se hace sin inducir la inmunosupresi\u00f3n; por consiguiente, la GMA ofrece un efecto terap\u00e9utico eficaz sin los efectos adversos debilitantes que suelen estar asociados a los f\u00e1rmacos inmunosupresores.<\/p>\n<p>Adacolumn\u00ae es un producto sanitario de clase IIb dise\u00f1ado para llevar a cabo la leucocitoaf\u00e9resis, que consiste en la eliminaci\u00f3n terap\u00e9utica selectiva de granulocitos y monocitos\/macr\u00f3fagos de la sangre perif\u00e9rica.<\/p>\n<p>El uso de Adacolumn\u00ae est\u00e1 autorizado en Jap\u00f3n y la Uni\u00f3n Europea desde 1999 y en China desde el a\u00f1o 2011.<\/p>\n      <\/div>\n    <\/div>\n        <a href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2024\/01\/Adacolumn-IFU_3_es_65-18.pdf\" title=\"Adacolumn IFU_1_en_63-18\" class=\"inline-block uppercase bg-white text-blue-d py-20 pl-30 pr-30 font-display font-bold text-16-40 lg:min-w-270 hover-fill-blue-l\" target=\"_blank\">INSTRUCCIONES DE USO<\/a>\n      <\/div>\n<\/div>\n\n\n<div class=\"max-w-987 mx-auto mb-85 px-20 lg:px-0 md:flex md:flex-wrap md:justify-between pt-65 lg:pt-100 lg:mb-200\" id=\"patient-material\">\n\n      <p class=\"text-blue-d font-display font-bold text-28-33 mb-45 md:mb-75\">Materiales de informaci\u00f3n para pacientes de Adacolumn\u00ae<\/p>\n    \n    <ul class=\"w-full md:flex md:flex-wrap md:justify-between\">\n\n          <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-1020037A-TRIPTIC-IBD-PATIENT-05.07.21-002-v3-FINAL.pdf\" target=\"_blank\" title=\"Adacolumn\u00ae Material informativo para pacientes con EII\">Adacolumn\u00ae Material informativo para pacientes con EII<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n            <li class=\"w-full md:w-48%\">\n        <a class=\"flex items-center justify-between text-20-24 mb-30 pb-30 border-b-2 border-blue-d uppercase font-display text-blue-d font-bold\" href=\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/03\/EN-ADA-1020037-TRIPTICO-AR-PACIENTE-05.07.21-002-V3-FINAL.pdf\" target=\"_blank\" title=\"Adacolumn\u00ae Material informativo para pacientes con artritis reumatoide\">Adacolumn\u00ae Material informativo para pacientes con artritis reumatoide<span class=\"flex ml-15 w-23\"><svg height=\"23\" viewBox=\"0 0 23 23\" width=\"23\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m1 12.7101036v8.5h21v-8.5h1v9.5h-23v-9.5zm11-12.7101036.001 15.774 6.142231-6.25696212.713538.70061652-7.356769 7.4924492-7.35676898-7.4924492.71353796-.70061652 6.14423102 6.25896212-.001-15.776z\" fill=\"#3ab0c8\"\/><\/svg><\/span><\/a>\n      <\/li>\n          <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>The rationale for the use of granulocyte-monocyte apheresis (GMA) in the treatment of IBD<\/p>\n","protected":false},"parent":0,"menu_order":0,"template":"","class_list":["post-5614","professional_product","type-professional_product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adacolumn\u00ae - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/es\/professional\/products\/adacolumn_\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adacolumn\u00ae - Adacyte\" \/>\n<meta property=\"og:description\" content=\"The rationale for the use of granulocyte-monocyte apheresis (GMA) in the treatment of IBD\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/es\/professional\/products\/adacolumn_\/\" 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