Therapeutic effect of intensive granulocyte and monocyte adsorption apheresis combined with thiopurines for steroid- and biologics-naive Japanese patients with early-diagnosed Crohn’s disease.

Takumi Fukuchi, Hiroshi Nakase ¹, Satoshi Ubukata, Minoru Matsuura, Takuya Yoshino, Takahiko Toyonaga, Keiji Shimazu, Hideaki Koga, Hiroshi Yamashita, Dai Ito, Kiyoshi Ashida, BMC Gastroenterol. 2014 Jul 11;13:124.

Combination therapy with intensive GMAA and thiopurines administration rapidly induced high remission in patients with active early-diagnosed CD without serious adverse effect. Mucosal healing was observed in 50.0% of enrolled patients. This combination therapy might be a rational option for patients with early-diagnosed CD.

https://pubmed.ncbi.nlm.nih.gov/25015328/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105052/pdf/1471-230X-14-124.pdf