{"id":9970,"date":"2024-01-04T14:02:00","date_gmt":"2024-01-04T13:02:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9970"},"modified":"2024-03-27T14:03:17","modified_gmt":"2024-03-27T13:03:17","slug":"dendritic-cells-the-yin-and-yang-in-disease-progression","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/","title":{"rendered":"Dendritic cells: the yin and yang in disease progression"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">Jim\u00e9nez-Cortegana Carlos , Palomares Francisca , Alba Gonzalo, Santa-Mar\u00eda Consuelo , de la Cruz-Merino Luis , S\u00e1nchez-Margalet Victor , L\u00f3pez-Enr\u00edquez Soledad  Frontiers in Immunology 14,2024, doi.org=10.3389\/fimmu.2023.1321051<\/p>\n<p>Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process and present antigens to activate na\u00efve T cells and originate favorable immune responses in many diseases, such as cancer. However, in the last decades, it has been observed that DCs not only promote beneficial responses, but also drive the initiation and progression of some pathologies, including inflammatory bowel disease (IBD). In line with those notions, different therapeutic approaches have been tested to enhance or impair the concentration and role of the different DC subsets. The blockade of inhibitory pathways to promote DCs or DC-based vaccines have been successfully assessed in cancer, whereas the targeting of DCs to inhibit their functionality has proved to be favorable in IBD. In this review, we (a) described the general role of DCs, (b) explained the DC subsets and their role in immunogenicity, (c) analyzed the role of DCs in cancer and therapeutic approaches to promote immunogenic DCs and (d) analyzed the role of DCs in IBD and therapeutic approaches to reduced DC-induced inflammation. Therefore, we aimed to highlight the \u201cyin-yang\u201d role of DCs to improve the understand of this type of cells in disease progression.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Jim\u00e9nez-Cortegana Carlos , Palomares Francisca , Alba Gonzalo, Santa-Mar\u00eda Consuelo , de la Cruz-Merino Luis , S\u00e1nchez-Margalet Victor , L\u00f3pez-Enr\u00edquez Soledad Frontiers in Immunology 14,2024, doi.org=10.3389\/fimmu.2023.1321051 Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[284,516,424,426,201,183,306],"class_list":["post-9970","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cd16","scientific_tags-dendritic-cells","scientific_tags-gma","scientific_tags-ibd","scientific_tags-il-10","scientific_tags-tnf-","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1321051\/full\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1321051\/full<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dendritic cells: the yin and yang in disease progression - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dendritic cells: the yin and yang in disease progression - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Jim\u00e9nez-Cortegana Carlos , Palomares Francisca , Alba Gonzalo, Santa-Mar\u00eda Consuelo , de la Cruz-Merino Luis , S\u00e1nchez-Margalet Victor , L\u00f3pez-Enr\u00edquez Soledad Frontiers in Immunology 14,2024, doi.org=10.3389\/fimmu.2023.1321051 Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T13:03:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/\",\"name\":\"Dendritic cells: the yin and yang in disease progression - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-04T13:02:00+00:00\",\"dateModified\":\"2024-03-27T13:03:17+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dendritic cells: the yin and yang in disease progression - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dendritic-cells-the-yin-and-yang-in-disease-progression\/","og_locale":"de_DE","og_type":"article","og_title":"Dendritic cells: the yin and yang in disease progression - Adacyte","og_description":"Jim\u00e9nez-Cortegana Carlos , Palomares Francisca , Alba Gonzalo, Santa-Mar\u00eda Consuelo , de la Cruz-Merino Luis , S\u00e1nchez-Margalet Victor , L\u00f3pez-Enr\u00edquez Soledad Frontiers in Immunology 14,2024, doi.org=10.3389\/fimmu.2023.1321051 Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. 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