{"id":9045,"date":"2023-08-16T16:45:13","date_gmt":"2023-08-16T14:45:13","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9045"},"modified":"2024-04-30T13:54:23","modified_gmt":"2024-04-30T11:54:23","slug":"intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/","title":{"rendered":"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Furuto+Y&amp;cauthor_id=37719478\">Yoshitaka Furuto<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sawada+R&amp;cauthor_id=37719478\">Rikimaru Sawada<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Namikawa+A&amp;cauthor_id=37719478\">Akio Namikawa<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Matsuhashi+N&amp;cauthor_id=37719478\">Nobuyuki Matsuhashi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Shibuya+Y&amp;cauthor_id=37719478\">Yuko Shibuya<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/#full-view-affiliation-1\">1<\/a><\/sup> Cureus.\u00a02023 Aug 16;15(8):e43599.\u00a0doi: 10.7759\/cureus.43599.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Granulocyte\/monocyte adsorptive apheresis (GMA) therapy is a treatment method for ulcerative colitis (UC). Twice-weekly GMA regimens are usually administered to treat severe UC. Although GMA efficacy is considered frequency-dependent, there is no uniformly accepted optimal GMA regimen, and there is insufficient evidence regarding optimal GMA therapy frequency for acute fulminant UC. Case 1 was of a 33-year-old man, and case 2 was of a 20-year-old woman. They were diagnosed with acute fulminant UC and treated with steroid therapy, but exhibited exacerbated UC, and their conditions worsened. We, therefore, initiated intensive frequent GMA therapy (conducted 10-11 times during a 13-day period). In both cases, remission was achieved within two weeks of therapy induction. Herein, we describe two consecutive cases in which rapid remission of acute fulminant UC was achieved without adverse events using intensive frequent GMA therapy. These cases suggest that intensive frequent GMA therapy might induce rapid remission in acute fulminant UC cases and may be more effective than twice-weekly GMA regimens.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/\">Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports &#8211; PubMed (nih.gov)<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10503873\/\">Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports &#8211; PMC (nih.gov)<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Yoshitaka Furuto\u00a01,\u00a0Rikimaru Sawada\u00a02,\u00a0Akio Namikawa\u00a01,\u00a0Nobuyuki Matsuhashi\u00a02,\u00a0Yuko Shibuya\u00a01 Cureus.\u00a02023 Aug 16;15(8):e43599.\u00a0doi: 10.7759\/cureus.43599. Granulocyte\/monocyte adsorptive apheresis (GMA) therapy is a treatment method for ulcerative colitis (UC). Twice-weekly GMA regimens are usually administered to treat severe UC. Although GMA efficacy is considered frequency-dependent, there is no uniformly accepted optimal GMA regimen, and there is insufficient evidence regarding optimal GMA [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[753,728,147,754,686,424,465,216,53,306],"class_list":["post-9045","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-acute-2","scientific_tags-case-report","scientific_tags-clinical-remission","scientific_tags-daily-sessions","scientific_tags-fulminant","scientific_tags-gma","scientific_tags-intensive","scientific_tags-rapid-efficay","scientific_tags-refractory-patients","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37719478\/<\/a>\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10503873\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10503873\/<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yoshitaka Furuto\u00a01,\u00a0Rikimaru Sawada\u00a02,\u00a0Akio Namikawa\u00a01,\u00a0Nobuyuki Matsuhashi\u00a02,\u00a0Yuko Shibuya\u00a01 Cureus.\u00a02023 Aug 16;15(8):e43599.\u00a0doi: 10.7759\/cureus.43599. Granulocyte\/monocyte adsorptive apheresis (GMA) therapy is a treatment method for ulcerative colitis (UC). Twice-weekly GMA regimens are usually administered to treat severe UC. Although GMA efficacy is considered frequency-dependent, there is no uniformly accepted optimal GMA regimen, and there is insufficient evidence regarding optimal GMA [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-30T11:54:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/\",\"name\":\"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2023-08-16T14:45:13+00:00\",\"dateModified\":\"2024-04-30T11:54:23+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/","og_locale":"de_DE","og_type":"article","og_title":"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte","og_description":"Yoshitaka Furuto\u00a01,\u00a0Rikimaru Sawada\u00a02,\u00a0Akio Namikawa\u00a01,\u00a0Nobuyuki Matsuhashi\u00a02,\u00a0Yuko Shibuya\u00a01 Cureus.\u00a02023 Aug 16;15(8):e43599.\u00a0doi: 10.7759\/cureus.43599. Granulocyte\/monocyte adsorptive apheresis (GMA) therapy is a treatment method for ulcerative colitis (UC). Twice-weekly GMA regimens are usually administered to treat severe UC. Although GMA efficacy is considered frequency-dependent, there is no uniformly accepted optimal GMA regimen, and there is insufficient evidence regarding optimal GMA [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/","og_site_name":"Adacyte","article_modified_time":"2024-04-30T11:54:23+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/","name":"Intensive Frequent Granulocyte Adsorptive Apheresis Therapy for Acute Fulminant Ulcerative Colitis: Two Consecutive Case Reports - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2023-08-16T14:45:13+00:00","dateModified":"2024-04-30T11:54:23+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/intensive-frequent-granulocyte-adsorptive-apheresis-therapy-for-acute-fulminant-ulcerative-colitis-two-consecutive-case-reports\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/9045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=9045"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=9045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}