{"id":9043,"date":"2023-04-03T15:25:12","date_gmt":"2023-04-03T13:25:12","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=9043"},"modified":"2024-04-30T14:02:40","modified_gmt":"2024-04-30T12:02:40","slug":"comparison-of-adsorption-efficiency-of-leukocytes-in-single-needle-gma-with-or-without-psl-treatment-in-patients-with-active-ulcerative-colitis-2","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/comparison-of-adsorption-efficiency-of-leukocytes-in-single-needle-gma-with-or-without-psl-treatment-in-patients-with-active-ulcerative-colitis-2\/","title":{"rendered":"Comparison of adsorption efficiency of leukocytes in single needle GMA with or without PSL treatment in patients with active ulcerative colitis"},"content":{"rendered":"
\n

Yuki Noguchi<\/a>\u00a01<\/a><\/sup>,\u00a0Keiji Shimazu<\/a>\u00a02<\/a><\/sup>,\u00a0Teruhiko Totani<\/a>\u00a01<\/a><\/sup>,\u00a0Kazumasa Komura<\/a>\u00a03<\/a><\/sup>,\u00a0Atsuo Tanaka<\/a>\u00a02<\/a><\/sup> Transfus Apher Sci. 2023 Apr;62(2):103581.\u00a0doi: 10.1016\/j.transci.2022.103581<\/p>\n<\/div>\n\n

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Granulocyte monocyte adsorption (GMA) is considered one of the modalities for the remission induction of ulcerative colitis (UC). We previously reported that single-needle GMA (SN-GMA) could simplify the GMA. In the present study, the efficiency of SNGMA was examined according to the administration of corticosteroids (PSL) in UC patients. Blood sample were taken at proximal and distal side of the column during the SN-GMA treatment. Disease activity score (partial Mayo score: pMayo score) before and after the SN-GMA was investigated. The data of 18 patients with active UC (11 and 7 patients with PSL na\u00efve and PSL use groups, respectively) treated with SN-GMA was analyzed. The mean pMayo score before the GMA treatment was comparable between the PSL na\u00efve group (p = 0.26), whereas the score after the GMA treatment was significantly lower in PSL na\u00efve group (0.8 + 0.6) than in PSL use group (3.0 + 2.1) (p = 0.04). Patients achieving the clinical remission were more observed in the PSL naive group (90.9%) than in the PSL use group (42.9%) (p = 0.047). The adsorption efficiency in the PSL na\u00efve and PSL use groups were as follows: leukocytes (34.45 \u00b1 7.43% vs 23.14 \u00b1 7.56%: p = 0.008), granulocytes (41.74 \u00b1 10.07% vs 27.99 \u00b1 15.11%: p = 0.04), monocytes (32.59 \u00b1 24.07% vs 33.16 \u00b1 24.18%: p = 0.95), and lymphocytes (-1.87 \u00b1 18.17% vs -3.79 \u00b1 22.52%: p = 0.84), with a significant difference of the absorption efficiency in leukocytes and granulocytes. These data collectively indicate that the SN-GMA can be applied for the remission induction to active UC patients with a higher clinical remission rate in PSL na\u00efve patients compared to PSL use patients.<\/p>\n<\/div>\n\n

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Comparison of adsorption efficiency of leukocytes in single needle GMA with or without PSL treatment in patients with active ulcerative colitis – PubMed (nih.gov)<\/a><\/p>\n<\/div>\n\n

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Comparison of adsorption efficiency of leukocytes in single needle GMA with or without PSL treatment in patients with active ulcerative colitis – Transfusion and Apheresis Science (trasci.com)<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Yuki Noguchi\u00a01,\u00a0Keiji Shimazu\u00a02,\u00a0Teruhiko Totani\u00a01,\u00a0Kazumasa Komura\u00a03,\u00a0Atsuo Tanaka\u00a02 Transfus Apher Sci. 2023 Apr;62(2):103581.\u00a0doi: 10.1016\/j.transci.2022.103581 Granulocyte monocyte adsorption (GMA) is considered one of the modalities for the remission induction of ulcerative colitis (UC). We previously reported that single-needle GMA (SN-GMA) could simplify the GMA. In the present study, the efficiency of SNGMA was examined according to the administration […]<\/p>\n","protected":false},"template":"","scientific_tags":[694,147,303,424,63,185,280,306],"class_list":["post-9043","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-adsortion-efficciency","scientific_tags-clinical-remission","scientific_tags-combination","scientific_tags-gma","scientific_tags-single-needle","scientific_tags-steroid-naive","scientific_tags-steroids","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/36167614\/<\/a>\r\n\r\nhttps:\/\/www.trasci.com\/article\/S1473-0502(22)00280-4\/abstract<\/a>"},"yoast_head":"\nComparison of adsorption efficiency of leukocytes in single needle GMA with or without PSL treatment in patients with active ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/comparison-of-adsorption-efficiency-of-leukocytes-in-single-needle-gma-with-or-without-psl-treatment-in-patients-with-active-ulcerative-colitis-2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparison of adsorption efficiency of leukocytes in single needle GMA with or without PSL treatment in patients with active ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yuki Noguchi\u00a01,\u00a0Keiji Shimazu\u00a02,\u00a0Teruhiko Totani\u00a01,\u00a0Kazumasa Komura\u00a03,\u00a0Atsuo Tanaka\u00a02 Transfus Apher Sci. 2023 Apr;62(2):103581.\u00a0doi: 10.1016\/j.transci.2022.103581 Granulocyte monocyte adsorption (GMA) is considered one of the modalities for the remission induction of ulcerative colitis (UC). 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