{"id":8622,"date":"2023-01-05T11:44:00","date_gmt":"2023-01-05T11:44:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=8622"},"modified":"2024-04-30T14:08:02","modified_gmt":"2024-04-30T12:08:02","slug":"combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/","title":{"rendered":"Combined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis"},"content":{"rendered":"
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Yoshikazu Tsuzuki<\/a>,\u00a0Rie Shiomi<\/a>,\u00a0Hisashi Matsumoto<\/a>,\u00a0Kazuya Miyaguchi<\/a>,\u00a0Takeru Kusano<\/a>,\u00a0Hideki Ohgo<\/a>,\u00a0Hidetomo Nakamoto<\/a>,\u00a0Hiroyuki Imaeda<\/a> J. Clin. Biochem. Nutr. 2023, 72 (1): 68-73. <\/a><\/p>\n<\/div>\n\n

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Several new treatments for ulcerative colitis have been developed recently. The depletion of leukocytes by granulocyte and monocyte adsorption apheresis (GMA) was developed and adapted for patients with ulcerative colitis with rare adverse events. We investigated whether treatment with GMA and prednisolone (GMA\u2005+\u2005PSL) is more effective than PSL alone for patients with moderate to severe ulcerative colitis. Forty-seven patients with moderate to severe ulcerative colitis were retrospectively analyzed. Among the 47 patients, 27 received PSL, while 20 received GMA\u2005+\u2005PSL. The clinical activity of ulcerative colitis was evaluated using the Lichtiger clinical activity index (CAI) and serum levels of C-reactive protein. Mayo endoscopic score (MES) was used to examine endoscopic activity. The clinical remission rate was significantly higher in the GMA\u2005+\u2005PSL group than in the PSL group (65% vs 29.6%,\u00a0p<\/em>\u2005=\u20050.0206). The mucosal healing rate was also significantly higher in the GMA\u2005+\u2005PSL group than in the PSL group (60% vs 26%,\u00a0p<\/em>\u2005=\u20050.0343). The combination of GMA and steroids may be more effective than steroids alone for inducing clinical remission and mucosal healing in patients with moderate to severe ulcerative colitis.<\/p>\n<\/div>\n\n

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JCM | Free Full-Text | An Update on Current Pharmacotherapeutic Options for the Treatment of Ulcerative Colitis (mdpi.com)<\/a><\/p>\n<\/div>\n\n

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ja (jst.go.jp)<\/a><\/p>\n<\/div>\n\n

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<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Yoshikazu Tsuzuki,\u00a0Rie Shiomi,\u00a0Hisashi Matsumoto,\u00a0Kazuya Miyaguchi,\u00a0Takeru Kusano,\u00a0Hideki Ohgo,\u00a0Hidetomo Nakamoto,\u00a0Hiroyuki Imaeda J. Clin. Biochem. Nutr. 2023, 72 (1): 68-73. Several new treatments for ulcerative colitis have been developed recently. The depletion of leukocytes by granulocyte and monocyte adsorption apheresis (GMA) was developed and adapted for patients with ulcerative colitis with rare adverse events. We investigated whether treatment […]<\/p>\n","protected":false},"template":"","scientific_tags":[147,303,138,157,397,424,627,308,156,306],"class_list":["post-8622","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-combination","scientific_tags-corticosteroids","scientific_tags-efficacy","scientific_tags-endoscopic-remission","scientific_tags-gma","scientific_tags-moderate-to-severe","scientific_tags-mucosal-healing","scientific_tags-safety","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"https:\/\/www.mdpi.com\/2077-0383\/11\/9\/2302<\/a>\r\n\r\nhttps:\/\/www.jstage.jst.go.jp\/article\/jcbn\/72\/1\/72_22-52\/_pdf\/-char\/ja<\/a>"},"yoast_head":"\nCombined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Combined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yoshikazu Tsuzuki,\u00a0Rie Shiomi,\u00a0Hisashi Matsumoto,\u00a0Kazuya Miyaguchi,\u00a0Takeru Kusano,\u00a0Hideki Ohgo,\u00a0Hidetomo Nakamoto,\u00a0Hiroyuki Imaeda J. Clin. Biochem. Nutr. 2023, 72 (1): 68-73. Several new treatments for ulcerative colitis have been developed recently. The depletion of leukocytes by granulocyte and monocyte adsorption apheresis (GMA) was developed and adapted for patients with ulcerative colitis with rare adverse events. We investigated whether treatment […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-30T12:08:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/\",\"name\":\"Combined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2023-01-05T11:44:00+00:00\",\"dateModified\":\"2024-04-30T12:08:02+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Combined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/combined-effects-of-granulocyte-and-monocyte-adsorption-apheresis-and-corticosteroids-on-ulcerative-colitis\/","og_locale":"de_DE","og_type":"article","og_title":"Combined effects of granulocyte and monocyte adsorption apheresis and corticosteroids on ulcerative colitis - Adacyte","og_description":"Yoshikazu Tsuzuki,\u00a0Rie Shiomi,\u00a0Hisashi Matsumoto,\u00a0Kazuya Miyaguchi,\u00a0Takeru Kusano,\u00a0Hideki Ohgo,\u00a0Hidetomo Nakamoto,\u00a0Hiroyuki Imaeda J. Clin. Biochem. Nutr. 2023, 72 (1): 68-73. Several new treatments for ulcerative colitis have been developed recently. The depletion of leukocytes by granulocyte and monocyte adsorption apheresis (GMA) was developed and adapted for patients with ulcerative colitis with rare adverse events. 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