{"id":8511,"date":"2005-04-01T10:42:00","date_gmt":"2005-04-01T10:42:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=8511"},"modified":"2022-10-26T10:45:56","modified_gmt":"2022-10-26T10:45:56","slug":"leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/","title":{"rendered":"Leukocytapheresis (LCAP) for Management<br>of Fulminant Ulcerative Colitis with<br>Toxic Megacolon"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Sawada+K&amp;cauthor_id=15844716\">Koji Sawada<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15844716\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Egashira+A&amp;cauthor_id=15844716\">Akimitsu Egashira<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ohnishi+K&amp;cauthor_id=15844716\">Kunio Ohnishi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Fukunaga+K&amp;cauthor_id=15844716\">Ken Fukunaga<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Kusaka+T&amp;cauthor_id=15844716\">Takeshi Kusaka<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Shimoyama+T&amp;cauthor_id=15844716\">Takashi Shimoyama<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Dig Dis Sci\u00a02005 Apr;50(4):767-73.\u00a0doi: 10.1007\/s10620-005-2571-3.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Leukocytapheresis (LCAP) is a method of therapeutic apheresis to remove patients&#8216; peripheral leukocytes by extracorporeal circulation. Previous studies showed that LCAP for the treatment of ulcerative colitis (UC) was more effective and had fewer adverse effects compared to high-dose steroid therapy. However, there are no reports on the application of LCAP for UC patients with toxic megacolon (TM). This study reports the effectiveness and safety of LCAP in treating patients with severe or fulminant UC with TM. Six patients were enrolled in this study and LCAP sessions were performed three times per week for 2 weeks, followed by four further times in the next 4 weeks. After completion of therapy, four patients improved in TM and went into the remission stage of UC. The average Rachmilewitz clinical activity index of these four patients improved from 19.5 to 1. The remaining two patients had to undergo colectomy, however, the symptoms had been mitigated by LCAP and the operations were completed without any problems. These results suggest that LCAP is an additional effective and safe option for TM management in preventing colectomy or for bridging to a safer operation.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15844716\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15844716\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Koji Sawada\u00a01,\u00a0Akimitsu Egashira,\u00a0Kunio Ohnishi,\u00a0Ken Fukunaga,\u00a0Takeshi Kusaka,\u00a0Takashi Shimoyama Dig Dis Sci\u00a02005 Apr;50(4):767-73.\u00a0doi: 10.1007\/s10620-005-2571-3. Leukocytapheresis (LCAP) is a method of therapeutic apheresis to remove patients&#8216; peripheral leukocytes by extracorporeal circulation. Previous studies showed that LCAP for the treatment of ulcerative colitis (UC) was more effective and had fewer adverse effects compared to high-dose steroid therapy. However, there [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,588,686,424,465,685,74,687,306],"class_list":["post-8511","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-clinical-response","scientific_tags-fulminant","scientific_tags-gma","scientific_tags-intensive","scientific_tags-lcap","scientific_tags-leukocytapheresis","scientific_tags-toxic-megacolon","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Leukocytapheresis (LCAP) for Managementof Fulminant Ulcerative Colitis withToxic Megacolon - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leukocytapheresis (LCAP) for Managementof Fulminant Ulcerative Colitis withToxic Megacolon - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Koji Sawada\u00a01,\u00a0Akimitsu Egashira,\u00a0Kunio Ohnishi,\u00a0Ken Fukunaga,\u00a0Takeshi Kusaka,\u00a0Takashi Shimoyama Dig Dis Sci\u00a02005 Apr;50(4):767-73.\u00a0doi: 10.1007\/s10620-005-2571-3. Leukocytapheresis (LCAP) is a method of therapeutic apheresis to remove patients&#8216; peripheral leukocytes by extracorporeal circulation. Previous studies showed that LCAP for the treatment of ulcerative colitis (UC) was more effective and had fewer adverse effects compared to high-dose steroid therapy. However, there [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-26T10:45:56+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/\",\"name\":\"Leukocytapheresis (LCAP) for Management of Fulminant Ulcerative Colitis with Toxic Megacolon - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2005-04-01T10:42:00+00:00\",\"dateModified\":\"2022-10-26T10:45:56+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Leukocytapheresis (LCAP) for Managementof Fulminant Ulcerative Colitis withToxic Megacolon - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/","og_locale":"de_DE","og_type":"article","og_title":"Leukocytapheresis (LCAP) for Managementof Fulminant Ulcerative Colitis withToxic Megacolon - Adacyte","og_description":"Koji Sawada\u00a01,\u00a0Akimitsu Egashira,\u00a0Kunio Ohnishi,\u00a0Ken Fukunaga,\u00a0Takeshi Kusaka,\u00a0Takashi Shimoyama Dig Dis Sci\u00a02005 Apr;50(4):767-73.\u00a0doi: 10.1007\/s10620-005-2571-3. Leukocytapheresis (LCAP) is a method of therapeutic apheresis to remove patients&#8216; peripheral leukocytes by extracorporeal circulation. Previous studies showed that LCAP for the treatment of ulcerative colitis (UC) was more effective and had fewer adverse effects compared to high-dose steroid therapy. However, there [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/","og_site_name":"Adacyte","article_modified_time":"2022-10-26T10:45:56+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/","name":"Leukocytapheresis (LCAP) for Management of Fulminant Ulcerative Colitis with Toxic Megacolon - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2005-04-01T10:42:00+00:00","dateModified":"2022-10-26T10:45:56+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-lcap-for-managementof-fulminant-ulcerative-colitis-withtoxic-megacolon\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/8511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=8511"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=8511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}