{"id":8498,"date":"2011-04-15T08:47:00","date_gmt":"2011-04-15T08:47:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=8498"},"modified":"2022-10-26T08:51:22","modified_gmt":"2022-10-26T08:51:22","slug":"a-multicenter-study-of-the-efficacy-and-safety-of-leukocytapheresis-therapy-without-concomitant-systemic-steroid-treatment-in-patients-with-active-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/a-multicenter-study-of-the-efficacy-and-safety-of-leukocytapheresis-therapy-without-concomitant-systemic-steroid-treatment-in-patients-with-active-ulcerative-colitis\/","title":{"rendered":"A multicenter study of the efficacy and safety of leukocytapheresis therapy without concomitant systemic steroid treatment in patients with active ulcerative colitis"},"content":{"rendered":"
\n

Toshifumi Ashida<\/a>\u00a01<\/a><\/sup>,\u00a0Yutaka Kohgo<\/a>,\u00a0Akihiro Munakata<\/a>,\u00a0Mitsunori Noguchi<\/a>,\u00a0Bunei Iizuka<\/a>,\u00a0Yutaka Endo<\/a>,\u00a0Hiroyuki Hanai<\/a>,\u00a0Toshikazu Yoshikawa<\/a>,\u00a0Takayuki Matsumoto<\/a>,\u00a0Nobuo Aoyama<\/a>,\u00a0Toshiyuki Matsui<\/a>,\u00a0Keiichi Mitsuyama<\/a>,\u00a0Toshifumi Hibi<\/a><\/p>\n<\/div>\n\n

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Transfus Apher Sci<\/a>\u00a02011 Apr;44(2):113-7.\u00a0doi: 10.1016\/j.transci.2011.01.001.<\/p>\n<\/div>\n\n

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We conducted a multicenter study to investigate the efficacy of leukocytapheresis (LCAP) without concomitant steroid therapy in active ulcerative colitis (UC) patients. Twenty patients were enrolled. LCAP was performed twice a week for 3 weeks. The results revealed a significant decrease of the Lichtiger’s clinical activity index (CAI) from 11.7\u00b12.6 at baseline to 6.6\u00b14.1 after the therapy. The endoscopic index and serum C-reactive protein levels also decreased significantly after the therapy. Of the 20 patients, 15 (75%) were assessed as responders (CAI\u22644 or \u0394CAI\u22653), and 7 (35%) achieved complete remission (CAI\u22644). No serious adverse reactions were encountered. The results suggest that LCAP is an effective and safe option for patients with active UC who had not received systemic steroid treatment.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/21402309\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Toshifumi Ashida\u00a01,\u00a0Yutaka Kohgo,\u00a0Akihiro Munakata,\u00a0Mitsunori Noguchi,\u00a0Bunei Iizuka,\u00a0Yutaka Endo,\u00a0Hiroyuki Hanai,\u00a0Toshikazu Yoshikawa,\u00a0Takayuki Matsumoto,\u00a0Nobuo Aoyama,\u00a0Toshiyuki Matsui,\u00a0Keiichi Mitsuyama,\u00a0Toshifumi Hibi Transfus Apher Sci\u00a02011 Apr;44(2):113-7.\u00a0doi: 10.1016\/j.transci.2011.01.001. We conducted a multicenter study to investigate the efficacy of leukocytapheresis (LCAP) without concomitant steroid therapy in active ulcerative colitis (UC) patients. Twenty patients were enrolled. LCAP was performed twice a week for 3 weeks. The […]<\/p>\n","protected":false},"template":"","scientific_tags":[147,157,601,424,74,100,156,309,271,306],"class_list":["post-8498","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-efficacy","scientific_tags-endoscopic-response","scientific_tags-gma","scientific_tags-leukocytapheresis","scientific_tags-multicenter","scientific_tags-safety","scientific_tags-steroid-free","scientific_tags-study","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nA multicenter study of the efficacy and safety of leukocytapheresis therapy without concomitant systemic steroid treatment in patients with active ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-multicenter-study-of-the-efficacy-and-safety-of-leukocytapheresis-therapy-without-concomitant-systemic-steroid-treatment-in-patients-with-active-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A multicenter study of the efficacy and safety of leukocytapheresis therapy without concomitant systemic steroid treatment in patients with active ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Toshifumi Ashida\u00a01,\u00a0Yutaka Kohgo,\u00a0Akihiro Munakata,\u00a0Mitsunori Noguchi,\u00a0Bunei Iizuka,\u00a0Yutaka Endo,\u00a0Hiroyuki Hanai,\u00a0Toshikazu Yoshikawa,\u00a0Takayuki Matsumoto,\u00a0Nobuo Aoyama,\u00a0Toshiyuki Matsui,\u00a0Keiichi Mitsuyama,\u00a0Toshifumi Hibi Transfus Apher Sci\u00a02011 Apr;44(2):113-7.\u00a0doi: 10.1016\/j.transci.2011.01.001. 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