{"id":8059,"date":"2009-05-04T09:51:00","date_gmt":"2009-05-04T09:51:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=8059"},"modified":"2022-05-04T09:57:14","modified_gmt":"2022-05-04T09:57:14","slug":"the-expression-profile-of-functional-regulatory-t-cells-cd4cd25high-forkhead-box-protein-p3-in-patients-with-ulcerative-colitis-during-active-and-quiescent-disease","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/the-expression-profile-of-functional-regulatory-t-cells-cd4cd25high-forkhead-box-protein-p3-in-patients-with-ulcerative-colitis-during-active-and-quiescent-disease\/","title":{"rendered":"The expression profile of functional regulatory T cells, CD4+CD25high+\/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease"},"content":{"rendered":"
\n

K Kamikozuru<\/a>\u00a01<\/a><\/sup>,\u00a0K Fukunaga<\/a>,\u00a0S Hirota<\/a>,\u00a0N Hida<\/a>,\u00a0Y Ohda<\/a>,\u00a0K Yoshida<\/a>,\u00a0Y Yokoyama<\/a>,\u00a0K Tozawa<\/a>,\u00a0K Kawa<\/a>,\u00a0M Iimuro<\/a>,\u00a0K Nagase<\/a>,\u00a0A R Saniabadi<\/a>,\u00a0S Nakamura<\/a>,\u00a0H Miwa<\/a>,\u00a0T Matsumoto<\/a> Clin Exp Immunol <\/a>2009 May;156(2):320-7.\u00a0doi: 10.1111\/j.1365-2249.2009.03904.x.\u00a0Epub 2009 Mar 9.<\/p>\n<\/div>\n\n

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Regulatory T cells (T(reg)) have an essential role in maintaining immune tolerance in the gut. The functional CD4(+) T(reg) express the transcription factor forkhead box protein 3 (FoxP3) or a CD25(high) in humans. Further, depletion of elevated granulocytes\/monocytes by extracorporeal adsorption (GMA) induces immunomodulation in patients with ulcerative colitis (UC). We investigated the impact of GMA on T(reg). Thirty-one UC patients, clinical activity index (CAI) 12.1 +\/- 2.97, refractory to conventional medications including intravenous corticosteroid and 13 healthy controls (HC), were included. Patients received five GMA sessions over 5 weeks. Biopsies from the rectal mucosa and blood samples at baseline and post-GMA were immunostained with anti-CD4\/FoxP3 and anti-CD4\/CD25 antibodies for immunohistochemistry and flow cytometry. Following GMA, 22 of 31 patients achieved remission (CAI <or= 4, P < 0.01) and their endoscopic activity index decreased from 10.6 +\/- 2.32 to 4.75 +\/- 1.48 (P = 0.003). The circulating CD4(+)CD25(high+) T(reg) level was low and increased markedly in responders (P < 0.02). In the nine non-responders, the baseline CD4(+)CD25(high+) T(reg) level was about 50% of the level in the responders (P < 0.03) or in the HC (P < 0.01), and all nine had to undergo colectomy. Conversely, the number of CD4(+)\/FoxP3(+) mucosal T(reg) in GMA responders decreased significantly after the fifth GMA session compared with the baseline level (P < 0.05). It is believed that the CD4(+) T(reg) has an essential role in the control of immune pathology in UC patients and a net influx of these cells from the circulation into the mucosa may proceed to suppress inflammation. GMA can impact the circulating as well as the mucosal levels of T(reg).<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/19292766\/<\/a><\/p>\n<\/div>\n\n

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https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2759481\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

K Kamikozuru\u00a01,\u00a0K Fukunaga,\u00a0S Hirota,\u00a0N Hida,\u00a0Y Ohda,\u00a0K Yoshida,\u00a0Y Yokoyama,\u00a0K Tozawa,\u00a0K Kawa,\u00a0M Iimuro,\u00a0K Nagase,\u00a0A R Saniabadi,\u00a0S Nakamura,\u00a0H Miwa,\u00a0T Matsumoto Clin Exp Immunol 2009 May;156(2):320-7.\u00a0doi: 10.1111\/j.1365-2249.2009.03904.x.\u00a0Epub 2009 Mar 9. Regulatory T cells (T(reg)) have an essential role in maintaining immune tolerance in the gut. The functional CD4(+) T(reg) express the transcription factor forkhead box protein 3 (FoxP3) or […]<\/p>\n","protected":false},"template":"","scientific_tags":[589,178,147,397,179,424,312,536,365,493,155,90,306],"class_list":["post-8059","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cd25highcd4-tcell","scientific_tags-cd4","scientific_tags-clinical-remission","scientific_tags-endoscopic-remission","scientific_tags-foxp3-t-cells","scientific_tags-gma","scientific_tags-immunology","scientific_tags-mucosa","scientific_tags-mucosal-biopsy","scientific_tags-peripheral","scientific_tags-serum","scientific_tags-tregs","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nThe expression profile of functional regulatory T cells, CD4+CD25high+\/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/the-expression-profile-of-functional-regulatory-t-cells-cd4cd25high-forkhead-box-protein-p3-in-patients-with-ulcerative-colitis-during-active-and-quiescent-disease\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The expression profile of functional regulatory T cells, CD4+CD25high+\/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease - Adacyte\" \/>\n<meta property=\"og:description\" content=\"K Kamikozuru\u00a01,\u00a0K Fukunaga,\u00a0S Hirota,\u00a0N Hida,\u00a0Y Ohda,\u00a0K Yoshida,\u00a0Y Yokoyama,\u00a0K Tozawa,\u00a0K Kawa,\u00a0M Iimuro,\u00a0K Nagase,\u00a0A R Saniabadi,\u00a0S Nakamura,\u00a0H Miwa,\u00a0T Matsumoto Clin Exp Immunol 2009 May;156(2):320-7.\u00a0doi: 10.1111\/j.1365-2249.2009.03904.x.\u00a0Epub 2009 Mar 9. 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