{"id":7152,"date":"2013-01-18T15:48:00","date_gmt":"2013-01-18T14:48:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=7152"},"modified":"2023-12-21T11:09:21","modified_gmt":"2023-12-21T10:09:21","slug":"multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/","title":{"rendered":"Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis"},"content":{"rendered":"
\n

Yusuke Okuyama<\/a>,Akira Andoh<\/a>,Masakazu Nishishita<\/a>,Ken Fukunaga<\/a>,Koji Kamikozuru<\/a>,Yoko Yokoyama<\/a>,Yoshitaka Ueno<\/a>,Shinji Tanaka<\/a>,Hiroyuki Kuge<\/a>,Syusaku Yoshikawa<\/a>,Atsushi Sugahara<\/a>,Emi Anami<\/a>,Yoshinori Munetomo<\/a>,Chiyuki Watanabe<\/a>,Yoshihide Fujiyama<\/a> &Takayuki Matsumot<\/a>o Scand. J. Gastro.<\/a> 2013, 48 (4)<\/a>, 412-418. https:\/\/doi.org\/10.3109\/00365521.2012.763175<\/a><\/p>\n<\/div>\n\n

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Objective.<\/em>\u00a0<\/strong>This study aimed to assess the efficacy and tolerability of leukocytapheresis (LCAP) and to investigate predictive factors for mucosal healing and a sustained clinical response in steroid-free and steroid-refractory patients with ulcerative colitis (UC).\u00a0Material and methods.\u00a0<\/strong>Thirty-one steroid-free or steroid-refractory patients with active UC were enrolled. Five or ten consecutive sessions of LCAP were performed in each patient. The efficacy and tolerability was then evaluated at weeks 3 and 6. Endoscopic examination was performed at week 6 to evaluate the mucosal healing, and the sustained cumulative response rate was evaluated at 12 months.\u00a0Results.\u00a0<\/strong>At week 6, the mean Mayo clinical activity score had decreased significantly from 8.0 to 4.6 in the steroid-free patients and from 8.3 to 3.9 in the steroid-refractory patients. Rachmilewitz’s endoscopic index had also decreased significantly from 9.1 to 6.1 in the steroid-free patients and from 10.0 to 5.7 in the steroid-refractory patients. Forty-seven percent of the steroid-free patients and 33% of the steroid-refractory patients achieved mucosal healing. The peripheral platelet counts had decreased significantly at weeks 3 and 6 in the mucosal healing group, compared with the non-mucosal healing group. The patients with a more than 15% platelet reduction had a significantly higher cumulative response rate, compared with the patients without a platelet reduction (p<\/em>\u00a0= 0.015).\u00a0Conclusions.\u00a0<\/strong>LCAP is beneficial for the induction of mucosal healing in steroid-free and steroid-refractory patients with UC. The degree of platelet reduction during LCAP might be a predictive marker for mucosal healing and a sustained clinical response.<\/p>\n<\/div>\n\n

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Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis – PubMed (nih.gov)<\/a><\/p>\n<\/div>\n\n

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Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis: Scandinavian Journal of Gastroenterology: Vol 48, No 4 (tandfonline.com)<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Yusuke Okuyama,Akira Andoh,Masakazu Nishishita,Ken Fukunaga,Koji Kamikozuru,Yoko Yokoyama,Yoshitaka Ueno,Shinji Tanaka,Hiroyuki Kuge,Syusaku Yoshikawa,Atsushi Sugahara,Emi Anami,Yoshinori Munetomo,Chiyuki Watanabe,Yoshihide Fujiyama &Takayuki Matsumoto Scand. J. Gastro. 2013, 48 (4), 412-418. https:\/\/doi.org\/10.3109\/00365521.2012.763175 Objective.\u00a0This study aimed to assess the efficacy and tolerability of leukocytapheresis (LCAP) and to investigate predictive factors for mucosal healing and a sustained clinical response in steroid-free and steroid-refractory patients […]<\/p>\n","protected":false},"template":"","scientific_tags":[588,157,601,424,74,308,100,427,204,97,156,309,605,271,616,615,306],"class_list":["post-7152","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-response","scientific_tags-efficacy","scientific_tags-endoscopic-response","scientific_tags-gma","scientific_tags-leukocytapheresis","scientific_tags-mucosal-healing","scientific_tags-multicenter","scientific_tags-platelet-count","scientific_tags-predictive-factors","scientific_tags-prospective","scientific_tags-safety","scientific_tags-steroid-free","scientific_tags-steroid-refractory-2","scientific_tags-study","scientific_tags-sustained-clinicla-reponse","scientific_tags-tolerability","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nMulticenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yusuke Okuyama,Akira Andoh,Masakazu Nishishita,Ken Fukunaga,Koji Kamikozuru,Yoko Yokoyama,Yoshitaka Ueno,Shinji Tanaka,Hiroyuki Kuge,Syusaku Yoshikawa,Atsushi Sugahara,Emi Anami,Yoshinori Munetomo,Chiyuki Watanabe,Yoshihide Fujiyama &Takayuki Matsumoto Scand. J. Gastro. 2013, 48 (4), 412-418. https:\/\/doi.org\/10.3109\/00365521.2012.763175 Objective.\u00a0This study aimed to assess the efficacy and tolerability of leukocytapheresis (LCAP) and to investigate predictive factors for mucosal healing and a sustained clinical response in steroid-free and steroid-refractory patients […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-21T10:09:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/\",\"name\":\"Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2013-01-18T14:48:00+00:00\",\"dateModified\":\"2023-12-21T10:09:21+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/multicenter-prospective-study-for-clinical-and-endoscopic-efficacies-of-leukocytapheresis-therapy-in-patients-with-ulcerative-colitis\/","og_locale":"de_DE","og_type":"article","og_title":"Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis - Adacyte","og_description":"Yusuke Okuyama,Akira Andoh,Masakazu Nishishita,Ken Fukunaga,Koji Kamikozuru,Yoko Yokoyama,Yoshitaka Ueno,Shinji Tanaka,Hiroyuki Kuge,Syusaku Yoshikawa,Atsushi Sugahara,Emi Anami,Yoshinori Munetomo,Chiyuki Watanabe,Yoshihide Fujiyama &Takayuki Matsumoto Scand. 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