{"id":7142,"date":"2007-04-21T12:14:00","date_gmt":"2007-04-21T12:14:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=7142"},"modified":"2022-04-01T12:19:39","modified_gmt":"2022-04-01T12:19:39","slug":"evaluation-of-5-versus-10-granulocyteaphaeresis-sessions-in-steroid-dependent-ulcerative-colitis-a-pilot-prospective-multicenter-randomized-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/evaluation-of-5-versus-10-granulocyteaphaeresis-sessions-in-steroid-dependent-ulcerative-colitis-a-pilot-prospective-multicenter-randomized-study\/","title":{"rendered":"Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ricart%20E%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Elena Ricart<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Esteve%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Maria Esteve<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Andreu%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Montserrat Andreu<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Casellas%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Francesc Casellas<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Monfort%20D%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">David Monfort<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Sans%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Miquel Sans<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Oudovenko%20N%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Natalia Oudovenko<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Lafuente%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Ra\u00fal Lafuente<\/a>, and\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Pan%26%23x000e9%3Bs%20J%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=17465500\">Juli\u00e1n Pan\u00e9s<\/a>  <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4146843\/#\">World J Gastroenterol.<\/a>\u00a02007 Apr 21; 13(15): 2193\u20132197.Published online 2007 Apr 21.\u00a0doi:\u00a0<a href=\"https:\/\/dx.doi.org\/10.3748%2Fwjg.v13.i15.2193\" target=\"_blank\" rel=\"noreferrer noopener\">10.3748\/wjg.v13.i15.2193<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p id=\"__p4\">AIM: To evaluate the efficacy of 5 compared to 10 granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis. METHODS: In this pilot, prospective, multicenter randomized trial, 20 patients with moderately active steroid-dependent ulcerative colitis were randomized to 5 or 10 granulocyteaphaeresis sessions. The primary objective was clinical remission at wk 17. Secondary measures included endoscopic remission and steroid consumption. RESULTS: Nine patients were randomized to 5 granulocyteaphaeresis sessions (group 1) and 11 patients to 10 granulocyteaphaeresis sessions (group 2). At wk 17, 37.5% of patients in group 1 and 45.45% of patients in group 2 were in clinical remission. Clinical remission was accompanied by endoscopic remission in all cases. Eighty-six percent of patients achieving remission were steroid-free at wk 17. Daily steroid requirements were significantly lower in group 2. Eighty-nine per cent of patients remained in remission during a one year follow-up. One serious adverse event, not related to the study therapy, was reported. CONCLUSION: Granulocyteaphaeresis is safe and effective for the treatment of steroid-dependent ulcerative colitis. In this population, increasing the number of aphaeresis sessions is not associated with higher remission rates, but affords a significant steroid-sparing effect.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4146843\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4146843\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Elena Ricart,\u00a0Maria Esteve,\u00a0Montserrat Andreu,\u00a0Francesc Casellas,\u00a0David Monfort,\u00a0Miquel Sans,\u00a0Natalia Oudovenko,\u00a0Ra\u00fal Lafuente, and\u00a0Juli\u00e1n Pan\u00e9s World J Gastroenterol.\u00a02007 Apr 21; 13(15): 2193\u20132197.Published online 2007 Apr 21.\u00a0doi:\u00a010.3748\/wjg.v13.i15.2193 AIM: To evaluate the efficacy of 5 compared to 10 granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis. METHODS: In this pilot, prospective, multicenter randomized trial, 20 patients with moderately active steroid-dependent [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,397,424,81,606,156,523,55,334,306],"class_list":["post-7142","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-endoscopic-remission","scientific_tags-gma","scientific_tags-long-term-outcome","scientific_tags-procedure","scientific_tags-safety","scientific_tags-steroid-tapering","scientific_tags-steroid-dependent","scientific_tags-steroid-free-remission","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/evaluation-of-5-versus-10-granulocyteaphaeresis-sessions-in-steroid-dependent-ulcerative-colitis-a-pilot-prospective-multicenter-randomized-study\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Elena Ricart,\u00a0Maria Esteve,\u00a0Montserrat Andreu,\u00a0Francesc Casellas,\u00a0David Monfort,\u00a0Miquel Sans,\u00a0Natalia Oudovenko,\u00a0Ra\u00fal Lafuente, and\u00a0Juli\u00e1n Pan\u00e9s World J Gastroenterol.\u00a02007 Apr 21; 13(15): 2193\u20132197.Published online 2007 Apr 21.\u00a0doi:\u00a010.3748\/wjg.v13.i15.2193 AIM: To evaluate the efficacy of 5 compared to 10 granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis. 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