{"id":7032,"date":"2007-10-24T12:04:00","date_gmt":"2007-10-24T12:04:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=7032"},"modified":"2022-03-24T15:19:35","modified_gmt":"2022-03-24T15:19:35","slug":"demonstration-of-low-regulatory-cd25highcd4-and-high-pro-inflammatory-cd28-cd4-t-cell-subsets-in-patients-with-ulcerative-colitis-modified-by-selective-granulocyte-and-monocyte-adsorption-apheresi","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/demonstration-of-low-regulatory-cd25highcd4-and-high-pro-inflammatory-cd28-cd4-t-cell-subsets-in-patients-with-ulcerative-colitis-modified-by-selective-granulocyte-and-monocyte-adsorption-apheresi\/","title":{"rendered":"Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis"},"content":{"rendered":"
\n

Yoko Yokoyama<\/a>\u00a01<\/a><\/sup>,\u00a0Ken Fukunaga<\/a>,\u00a0Yoshihiro Fukuda<\/a>,\u00a0Katsuyuki Tozawa<\/a>,\u00a0Koji Kamikozuru<\/a>,\u00a0Kunio Ohnishi<\/a>,\u00a0Takeshi Kusaka<\/a>,\u00a0Tadashi Kosaka<\/a>,\u00a0Nobuyuki Hida<\/a>,\u00a0Yoshio Ohda<\/a>,\u00a0Hiroto Miwa<\/a>,\u00a0Takayuki Matsumoto<\/a> Dig Dis Sci<\/a>\u00a02007 Oct;52(10):2725-31.\u00a0doi: 10.1007\/s10620-006-9560-z.\u00a0Epub 2007 Apr 3.<\/p>\n<\/div>\n\n

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Low-CD25(High+)CD4(+), a subset of regulatory CD25(+)CD4(+) T cells and high-inflammatory CD28(-)CD4(+) T cells can exacerbate ulcerative colitis (UC). This study sought to investigate the frequency of CD25(High+)CD4(+) and CD28(-)CD4(+) T cells in patients with UC and the changes in these cells during Adacolumn granulocyte and monocyte adsorption apheresis (GMA). Subjects were 12 patients with active UC, 11 with quiescent UC, and 14 healthy volunteers (HVs). The mean clinical activity index was 15.7 +\/- 2.2 in active UC and 4.5 +\/- 1.1 in quiescent UC. Peripheral blood samples were stained with CD4, CD25, and CD28 antibodies for flow cytometry. Patients with active UC received GMA and blood samples were examined before and after the first GMA session. Patients with active UC (P < 0.04) or quiescent UC (P < 0.02) had a higher percentage of CD28(-)D4(+)T cells compared with HVs, while the percentage of CD28(+)CD4(+) T cells was lower in both UC groups compared with HVs (P = 0.03 and P < 0.02). Patients with active UC had a lower percentage of CD25(High+)CD4(+)T cells compared with quiescent UC patients (P < 0.001). A significant increase in CD25(High+)CD4(+) T cells was associated with GMA (P < 0.03). Low CD25(High+)CD4(+) and high CD28(-)CD4(+) are prominent features in UC. The increase in CD25(High+)CD4(+) T cells induced by GMA should contribute to improved immune function. Additional studies are warranted, since a low frequency of CD25(High+)CD4(+) (-) and a high frequency of CD28(-)CD4(+) (-) expressing T cells might be a predictor of clinical response to GMA.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/17404876\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Yoko Yokoyama\u00a01,\u00a0Ken Fukunaga,\u00a0Yoshihiro Fukuda,\u00a0Katsuyuki Tozawa,\u00a0Koji Kamikozuru,\u00a0Kunio Ohnishi,\u00a0Takeshi Kusaka,\u00a0Tadashi Kosaka,\u00a0Nobuyuki Hida,\u00a0Yoshio Ohda,\u00a0Hiroto Miwa,\u00a0Takayuki Matsumoto Dig Dis Sci\u00a02007 Oct;52(10):2725-31.\u00a0doi: 10.1007\/s10620-006-9560-z.\u00a0Epub 2007 Apr 3. Low-CD25(High+)CD4(+), a subset of regulatory CD25(+)CD4(+) T cells and high-inflammatory CD28(-)CD4(+) T cells can exacerbate ulcerative colitis (UC). This study sought to investigate the frequency of CD25(High+)CD4(+) and CD28(-)CD4(+) T cells in patients with […]<\/p>\n","protected":false},"template":"","scientific_tags":[561,589,590,178,424,173,591,169,256,306],"class_list":["post-7032","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-active","scientific_tags-cd25highcd4-tcell","scientific_tags-cd28-cd4-tcell","scientific_tags-cd4","scientific_tags-gma","scientific_tags-moa","scientific_tags-quiescent","scientific_tags-t-lymphocytes","scientific_tags-treg","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nDemonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/demonstration-of-low-regulatory-cd25highcd4-and-high-pro-inflammatory-cd28-cd4-t-cell-subsets-in-patients-with-ulcerative-colitis-modified-by-selective-granulocyte-and-monocyte-adsorption-apheresi\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yoko Yokoyama\u00a01,\u00a0Ken Fukunaga,\u00a0Yoshihiro Fukuda,\u00a0Katsuyuki Tozawa,\u00a0Koji Kamikozuru,\u00a0Kunio Ohnishi,\u00a0Takeshi Kusaka,\u00a0Tadashi Kosaka,\u00a0Nobuyuki Hida,\u00a0Yoshio Ohda,\u00a0Hiroto Miwa,\u00a0Takayuki Matsumoto Dig Dis Sci\u00a02007 Oct;52(10):2725-31.\u00a0doi: 10.1007\/s10620-006-9560-z.\u00a0Epub 2007 Apr 3. 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