{"id":7017,"date":"2007-11-14T09:57:00","date_gmt":"2007-11-14T09:57:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=7017"},"modified":"2022-03-24T10:31:43","modified_gmt":"2022-03-24T10:31:43","slug":"granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect-2","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect-2\/","title":{"rendered":"Granulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect"},"content":{"rendered":"
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B.J. Rembacken<\/a>,H.E. Newbould<\/a>,S.J. Richards<\/a>,S.A. Misbah<\/a>,M.E. Dixon<\/a>,D.M. Chalmers<\/a>,A.T.R. Axon<\/a> THERAP APHERE DIAL (2007) 2 (2) 93-96<\/a>  https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x<\/a><\/p>\n<\/div>\n\n

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We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column. We found a mean reduction in circulating granulocytes of 1.29 \u00d7 109<\/sup>\u00a0cells\/L with no significant alterations in red blood cell monocyte, total lymphocyte, absolute T-helper, or T-cytotoxic lymphocyte counts. There were no significant changes in complement levels or immunoglobulin subclasses. There was a signifycant increase in granulocyte adhesion and a reduction in L-selectin expression. The removal of granulocytes is unlikely to explain the effect of granulocytapheresis. The markedly increased expression of \u03b1m<\/sub>\u00a0integrin\/Mac-1 and low L-selectin expression alter the capability of granulocytes to migrate to sites of inflammation and may be responsible for the improvement observed in patients treated with granulocyte apheresis.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/10225706\/<\/p>\n<\/div>\n\n

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https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/j.1744-9987.1998.tb00082.x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

B.J. Rembacken,H.E. Newbould,S.J. Richards,S.A. Misbah,M.E. Dixon,D.M. Chalmers,A.T.R. Axon THERAP APHERE DIAL (2007) 2 (2) 93-96  https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column. We […]<\/p>\n","protected":false},"template":"","scientific_tags":[424,105,426,571,230,194,173,107,169],"class_list":["post-7017","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-gma","scientific_tags-granulocyte","scientific_tags-ibd","scientific_tags-integrin","scientific_tags-lecam-1l-selectin","scientific_tags-mac-1","scientific_tags-moa","scientific_tags-monocyte","scientific_tags-t-lymphocytes"],"acf":{"sc_authors":""},"yoast_head":"\nGranulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-apheresis-in-inflammatory-bowel-disease-possible-mechanisms-of-effect-2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte Apheresis in Inflammatory Bowel Disease: Possible Mechanisms of Effect - Adacyte\" \/>\n<meta property=\"og:description\" content=\"B.J. Rembacken,H.E. Newbould,S.J. Richards,S.A. Misbah,M.E. Dixon,D.M. Chalmers,A.T.R. Axon THERAP APHERE DIAL (2007) 2 (2) 93-96  https:\/\/doi.org\/10.1111\/j.1744-9987.1998.tb00082.x We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis and 6 with Crohn’s disease who had failed to respond to conventional therapy. Patients were treated with weekly apheresis using a granulocyte removal column. 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