{"id":6986,"date":"2004-09-01T14:36:00","date_gmt":"2004-09-01T14:36:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6986"},"modified":"2022-03-01T14:39:45","modified_gmt":"2022-03-01T14:39:45","slug":"granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/","title":{"rendered":"Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Premchand+P&amp;cauthor_id=15316424\">Purushothaman Premchand<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15316424\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takeuchi+K&amp;cauthor_id=15316424\">Ken Takeuchi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bjarnason+I&amp;cauthor_id=15316424\">Ingvar Bjarnason<\/a> Eur J Gastroenterol Hepatol <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Eur+J+Gastroenterol+Hepatol%22%5Bjour%5D\"><\/a>2004 Sep;16(9):943-5.\u00a0doi: 10.1097\/00042737-200409000-00023.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Refractory ulcerative colitis that fails conventional intense medical treatment often leads to colectomy. Although ciclosporin and infliximab may avert colectomy in certain cases, these treatments come with substantial toxicity and may only act as a bridge to avert emergency surgery. Granulocyte monocyte\/macrophage adsorption apheresis is a new treatment and has shown efficacy for refractory colitis in up to 80% of cases in a Japanese study and is apparently only associated with negligible side effects. We report a case of severe refractory proctitis destined for colectomy effectively treated with granulocyte monocyte\/macrophage adsorption apheresis. After two of five sessions the patient achieved full clinical remission, which has been sustained with the addition of azathioprine for more than 1 year.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15316424\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15316424\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Purushothaman Premchand\u00a01,\u00a0Ken Takeuchi,\u00a0Ingvar Bjarnason Eur J Gastroenterol Hepatol 2004 Sep;16(9):943-5.\u00a0doi: 10.1097\/00042737-200409000-00023. Refractory ulcerative colitis that fails conventional intense medical treatment often leads to colectomy. Although ciclosporin and infliximab may avert colectomy in certain cases, these treatments come with substantial toxicity and may only act as a bridge to avert emergency surgery. Granulocyte monocyte\/macrophage adsorption apheresis [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[99,147,303,424,339,461,184,306],"class_list":["post-6986","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-azathioprine","scientific_tags-clinical-remission","scientific_tags-combination","scientific_tags-gma","scientific_tags-proctitis","scientific_tags-refractory","scientific_tags-thiopurines","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Purushothaman Premchand\u00a01,\u00a0Ken Takeuchi,\u00a0Ingvar Bjarnason Eur J Gastroenterol Hepatol 2004 Sep;16(9):943-5.\u00a0doi: 10.1097\/00042737-200409000-00023. Refractory ulcerative colitis that fails conventional intense medical treatment often leads to colectomy. Although ciclosporin and infliximab may avert colectomy in certain cases, these treatments come with substantial toxicity and may only act as a bridge to avert emergency surgery. Granulocyte monocyte\/macrophage adsorption apheresis [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-03-01T14:39:45+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/\",\"name\":\"Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2004-09-01T14:36:00+00:00\",\"dateModified\":\"2022-03-01T14:39:45+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-macrophage-monocyte-apheresis-for-refractory-ulcerative-proctitis\/","og_locale":"de_DE","og_type":"article","og_title":"Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis - Adacyte","og_description":"Purushothaman Premchand\u00a01,\u00a0Ken Takeuchi,\u00a0Ingvar Bjarnason Eur J Gastroenterol Hepatol 2004 Sep;16(9):943-5.\u00a0doi: 10.1097\/00042737-200409000-00023. Refractory ulcerative colitis that fails conventional intense medical treatment often leads to colectomy. Although ciclosporin and infliximab may avert colectomy in certain cases, these treatments come with substantial toxicity and may only act as a bridge to avert emergency surgery. 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