{"id":6983,"date":"2021-10-20T14:53:00","date_gmt":"2021-10-20T14:53:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6983"},"modified":"2024-05-02T09:41:43","modified_gmt":"2024-05-02T07:41:43","slug":"complete-resolution-of-mucosal-neutrophils-associates-with-improved-long-term-clinical-outcomes-of-patients-with-ulcerative-colitis-2","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/complete-resolution-of-mucosal-neutrophils-associates-with-improved-long-term-clinical-outcomes-of-patients-with-ulcerative-colitis-2\/","title":{"rendered":"Complete Resolution of Mucosal Neutrophils Associates With Improved Long-Term Clinical Outcomes of Patients With Ulcerative Colitis"},"content":{"rendered":"
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Rish K Pai<\/a>\u00a01<\/a><\/sup>,\u00a0Douglas J Hartman<\/a>\u00a02<\/a><\/sup>,\u00a0Claudia Ramos Rivers<\/a>\u00a03<\/a><\/sup>,\u00a0Miguel Regueiro<\/a>\u00a04<\/a><\/sup>,\u00a0Marc Schwartz<\/a>\u00a03<\/a><\/sup>,\u00a0David G Binion<\/a>\u00a03<\/a><\/sup>,\u00a0Reetesh K Pai<\/a>\u00a0<\/sup>Clin Gastroenterol Hepatol <\/a>2020 Oct;18(11):2510-2517.e5.\u00a0doi: 10.1016\/j.cgh.2019.12.011.\u00a0Epub 2019 Dec 14.<\/p>\n<\/div>\n\n

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Background & aims:\u00a0<\/strong>We investigated correlations between histologic features of the colonic mucosa in patients with ulcerative colitis (UC) and clinical outcomes during a 3-year follow-up period. Methods:\u00a0<\/strong>We obtained baseline biopsies from all colorectal segments (n = 889) from 281 patients with UC enrolled in a prospective study at a single center from 2009 through 2013. Biopsies were assessed in a blinded manner using validated histologic scoring systems (the Geboes score, Nancy histopathologic index, and Robarts histopathologic index). Clinical, endoscopic, and histologic data were collected and tested for correlations with systemic corticosteroid use, hospitalization, and colectomy within 3 years of the index colonoscopy. Results:\u00a0<\/strong>We found histologic evidence of UC activity (Geboes score \u2265 2B.1) in biopsies from 182 patients (65%) and endoscopic evidence of UC activity in 149 patients (53%) (substantial agreement, \u03ba = 0.60). Histologic features of UC activity were associated with increased rates of systemic corticosteroid use, colectomy, and hospitalization in the entire cohort (P < .05 for all) and associated with increased rates of systemic corticosteroid use in an analysis limited to patients in endoscopic remission (P < .001). In patients in endoscopic remission, only histologic activity was independently associated with use of systemic corticosteroids (multivariate odds ratio, 6.34; 95% CI, 2.20-18.28; P = .001). Similar results were seen when the entire cohort was analyzed. Compared with patients without histologic evidence of UC activity, patients with only a small number of mucosal neutrophils still had higher rates of systemic corticosteroid use (P < .001). Conclusions:\u00a0<\/strong>Histologic evidence of UC activity, including small numbers of neutrophils in the colonic mucosa, is the only factor independently associated with use of systemic corticosteroids. Complete resolution of neutrophil-associated inflammation should be a target for treatment of UC.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/31843598\/<\/a><\/p>\n<\/div>\n\n

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https:\/\/www.cghjournal.org\/article\/S1542-3565(19)31438-7\/fulltext<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Rish K Pai\u00a01,\u00a0Douglas J Hartman\u00a02,\u00a0Claudia Ramos Rivers\u00a03,\u00a0Miguel Regueiro\u00a04,\u00a0Marc Schwartz\u00a03,\u00a0David G Binion\u00a03,\u00a0Reetesh K Pai\u00a0Clin Gastroenterol Hepatol 2020 Oct;18(11):2510-2517.e5.\u00a0doi: 10.1016\/j.cgh.2019.12.011.\u00a0Epub 2019 Dec 14. Background & aims:\u00a0We investigated correlations between histologic features of the colonic mucosa in patients with ulcerative colitis (UC) and clinical outcomes during a 3-year follow-up period. Methods:\u00a0We obtained baseline biopsies from all colorectal segments […]<\/p>\n","protected":false},"template":"","scientific_tags":[147,554,138,397,552,308,445,366,527,306],"class_list":["post-6983","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-colonic-mucosa","scientific_tags-corticosteroids","scientific_tags-endoscopic-remission","scientific_tags-histological-remission","scientific_tags-mucosal-healing","scientific_tags-neutrophil","scientific_tags-neutrophil-infiltration","scientific_tags-steroid","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/31843598\/<\/a>\r\n\r\nhttps:\/\/www.cghjournal.org\/article\/S1542-3565(19)31438-7\/fulltext<\/a>"},"yoast_head":"\nComplete Resolution of Mucosal Neutrophils Associates With Improved Long-Term Clinical Outcomes of Patients With Ulcerative Colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/complete-resolution-of-mucosal-neutrophils-associates-with-improved-long-term-clinical-outcomes-of-patients-with-ulcerative-colitis-2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Complete Resolution of Mucosal Neutrophils Associates With Improved Long-Term Clinical Outcomes of Patients With Ulcerative Colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Rish K Pai\u00a01,\u00a0Douglas J Hartman\u00a02,\u00a0Claudia Ramos Rivers\u00a03,\u00a0Miguel Regueiro\u00a04,\u00a0Marc Schwartz\u00a03,\u00a0David G Binion\u00a03,\u00a0Reetesh K Pai\u00a0Clin Gastroenterol Hepatol 2020 Oct;18(11):2510-2517.e5.\u00a0doi: 10.1016\/j.cgh.2019.12.011.\u00a0Epub 2019 Dec 14. Background & aims:\u00a0We investigated correlations between histologic features of the colonic mucosa in patients with ulcerative colitis (UC) and clinical outcomes during a 3-year follow-up period. 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