{"id":6628,"date":"2009-08-03T14:33:00","date_gmt":"2009-08-03T14:33:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6628"},"modified":"2022-01-28T14:33:41","modified_gmt":"2022-01-28T14:33:41","slug":"treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/","title":{"rendered":"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hibi+T&amp;cauthor_id=19211314\">T Hibi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19211314\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sameshima+Y&amp;cauthor_id=19211314\">Y Sameshima<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sekiguchi+Y&amp;cauthor_id=19211314\">Y Sekiguchi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hisatome+Y&amp;cauthor_id=19211314\">Y Hisatome<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Maruyama+F&amp;cauthor_id=19211314\">F Maruyama<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Moriwaki+K&amp;cauthor_id=19211314\">K Moriwaki<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Shima+C&amp;cauthor_id=19211314\">C Shima<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Saniabadi+AR&amp;cauthor_id=19211314\">A R Saniabadi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Matsumoto+T&amp;cauthor_id=19211314\">T Matsumoto<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Dig Liver Dis. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Dig+Liver+Dis%22%5Bjour%5D\"><\/a>2009 Aug;41(8):570-7.\u00a0doi: 10.1016\/j.dld.2008.11.020.\u00a0Epub 2009 Feb 10.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background\/aim:\u00a0<\/strong>The Adacolumn selectively depletes granulocytes and monocytes\/macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis. This work aims at evaluating the safety and clinical efficacy of the Adacolumn in patients with ulcerative colitis in large population-based data sets. <strong>Methods:\u00a0<\/strong>The Adacolumn post marketing surveillance in Japan was undertaken on 697 patients in 53 medical institutions over 7 years from 29 October 1999 to 28 October 2006. Clinical efficacy and safety data were provided by patients&#8216; physicians in the participating institutes. <strong>Results:\u00a0<\/strong>Safety was evaluated in all the 697 patients and efficacy in 656 patients. At entry, 92% of the patients were on salicylates, 74% on prednisolone and only 9% on immunomodulators. Approximately 40% of patients had severe ulcerative colitis and over 70% had ulcerative colitis that was refractory to conventional medications. There was no serious adverse events; mild to moderate adverse events were seen in 7.7% of the patients. The overall response (remission or significantly improved) was 77.3%; the remission rate based on clinical activity index was 71.1%, while 17.1% remained unchanged and 5.6% worsened. Patients were subgrouped into severe, moderate and mild ulcerative colitis based on clinical activity index (n=578), the response rates were 63.2%, 65.7% and 80.4%, respectively (P&lt;0.001). Endoscopic assessment of efficacy showed very significant mucosal healing, Matts&#8216; endoscopic index improved from 3.2+\/-0.04 to 2.1+\/-0.7 (n=219, P&lt;0.001); reduction in prednisolone dose (P&lt;0.0001); leucocyte count (n=358, P&lt;0.0001) and C-reactive protein (n=314, P&lt;0.0001). Patients who received > or =6 Adacolumn sessions (n=319) did better than patients who received &lt; or =5 sessions (n=188, P=0.004) and multivariate logistic regression analysis revealed that baseline granulocyte count was the strongest predictor of clinical response to Adacolumn (P=0.0191, odds ratio 1.151). <strong>Conclusion:\u00a0<\/strong>This post marketing surveillance provides the largest ever efficacy and safety data on the Adacolumn therapeutic leucocytapheresis in patients with ulcerative colitis. As a non-pharmacologic treatment for patients with active ulcerative colitis most of whom were refractory to conventional drug therapy, the observed efficacy was very significant. Baseline granulocyte count was convincingly an independent predictor of clinical response.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19211314\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/19211314\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>T Hibi\u00a01,\u00a0Y Sameshima,\u00a0Y Sekiguchi,\u00a0Y Hisatome,\u00a0F Maruyama,\u00a0K Moriwaki,\u00a0C Shima,\u00a0A R Saniabadi,\u00a0T Matsumoto Dig Liver Dis. 2009 Aug;41(8):570-7.\u00a0doi: 10.1016\/j.dld.2008.11.020.\u00a0Epub 2009 Feb 10. Background\/aim:\u00a0The Adacolumn selectively depletes granulocytes and monocytes\/macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis. This work aims at evaluating the safety and clinical efficacy of the Adacolumn in patients with [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,157,424,105,426,74,308,445,204,53,156,354,523,306],"class_list":["post-6628","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-granulocyte","scientific_tags-ibd","scientific_tags-leukocytapheresis","scientific_tags-mucosal-healing","scientific_tags-neutrophil","scientific_tags-predictive-factors","scientific_tags-refractory-patients","scientific_tags-safety","scientific_tags-steroid-sparing","scientific_tags-steroid-tapering","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte\" \/>\n<meta property=\"og:description\" content=\"T Hibi\u00a01,\u00a0Y Sameshima,\u00a0Y Sekiguchi,\u00a0Y Hisatome,\u00a0F Maruyama,\u00a0K Moriwaki,\u00a0C Shima,\u00a0A R Saniabadi,\u00a0T Matsumoto Dig Liver Dis. 2009 Aug;41(8):570-7.\u00a0doi: 10.1016\/j.dld.2008.11.020.\u00a0Epub 2009 Feb 10. Background\/aim:\u00a0The Adacolumn selectively depletes granulocytes and monocytes\/macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis. This work aims at evaluating the safety and clinical efficacy of the Adacolumn in patients with [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-28T14:33:41+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/\",\"name\":\"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2009-08-03T14:33:00+00:00\",\"dateModified\":\"2022-01-28T14:33:41+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/","og_locale":"de_DE","og_type":"article","og_title":"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte","og_description":"T Hibi\u00a01,\u00a0Y Sameshima,\u00a0Y Sekiguchi,\u00a0Y Hisatome,\u00a0F Maruyama,\u00a0K Moriwaki,\u00a0C Shima,\u00a0A R Saniabadi,\u00a0T Matsumoto Dig Liver Dis. 2009 Aug;41(8):570-7.\u00a0doi: 10.1016\/j.dld.2008.11.020.\u00a0Epub 2009 Feb 10. Background\/aim:\u00a0The Adacolumn selectively depletes granulocytes and monocytes\/macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis. This work aims at evaluating the safety and clinical efficacy of the Adacolumn in patients with [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/","og_site_name":"Adacyte","article_modified_time":"2022-01-28T14:33:41+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"2\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/","name":"Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2009-08-03T14:33:00+00:00","dateModified":"2022-01-28T14:33:41+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/treating-ulcerative-colitis-by-adacolumn-therapeutic-leucocytapheresis-clinical-efficacy-and-safety-based-on-surveillance-of-656-patients-in-53-centres-in-japan\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/6628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=6628"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=6628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}