{"id":6617,"date":"2008-02-06T15:41:00","date_gmt":"2008-02-06T15:41:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6617"},"modified":"2022-01-27T15:46:22","modified_gmt":"2022-01-27T15:46:22","slug":"reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/","title":{"rendered":"Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Waitz+G&amp;cauthor_id=18253828\">Grit Waitz<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18253828\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Petermann+S&amp;cauthor_id=18253828\">Sebastian Petermann<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Liebe+S&amp;cauthor_id=18253828\">Stefan Liebe<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Emmrich+J&amp;cauthor_id=18253828\">Joerg Emmrich<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ramlow+W&amp;cauthor_id=18253828\">Wolfgang Ramlow<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Dig Dis Sci. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Dig+Dis+Sci%22%5Bjour%5D\"><\/a>2008 Sep;53(9):2507-15.\u00a0doi: 10.1007\/s10620-007-0168-8.\u00a0Epub 2008 Feb 6.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>The influence of the granulocyte\/monocyte apheresis (GMCAP) on cell populations participating in mechanisms of tolerance, e.g. dendritic cells (DCs), is still not very clear. In a first step, we aimed to investigate changes in the DC population of patients suffering from ulcerative colitis (UC) (n = 13) compared to healthy subjects (n = 9). In a second step, we studied the changes in peripheral DCs in a small group of patients with active UC before and after Adacolumn apheresis (n = 7). For this purpose, plasmacytoid and myeloid DCs and their maturation markers CD40, CD80, and CD86 were measured using four-color flow cytometry in the peripheral blood. After apheresis, and in acute flare-ups, we identified a significantly lower number of lymphocytes, plasmacytoid, and myeloid DCs. In conclusion, the additional removal of peripheral DCs by GMCAP, which otherwise would contribute to the inflammatory process in the gut, may lead to a higher tolerogeneic status towards luminal antigens.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18253828\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18253828\/<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs10620-007-0168-8\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007%2Fs10620-007-0168-8<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Grit Waitz\u00a01,\u00a0Sebastian Petermann,\u00a0Stefan Liebe,\u00a0Joerg Emmrich,\u00a0Wolfgang Ramlow Dig Dis Sci. 2008 Sep;53(9):2507-15.\u00a0doi: 10.1007\/s10620-007-0168-8.\u00a0Epub 2008 Feb 6. The influence of the granulocyte\/monocyte apheresis (GMCAP) on cell populations participating in mechanisms of tolerance, e.g. dendritic cells (DCs), is still not very clear. In a first step, we aimed to investigate changes in the DC population of patients suffering [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[516,424,386,173,518,169,519,306],"class_list":["post-6617","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-dendritic-cells","scientific_tags-gma","scientific_tags-leukocyte","scientific_tags-moa","scientific_tags-plasmacytoid","scientific_tags-t-lymphocytes","scientific_tags-tolerogenic","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Grit Waitz\u00a01,\u00a0Sebastian Petermann,\u00a0Stefan Liebe,\u00a0Joerg Emmrich,\u00a0Wolfgang Ramlow Dig Dis Sci. 2008 Sep;53(9):2507-15.\u00a0doi: 10.1007\/s10620-007-0168-8.\u00a0Epub 2008 Feb 6. The influence of the granulocyte\/monocyte apheresis (GMCAP) on cell populations participating in mechanisms of tolerance, e.g. dendritic cells (DCs), is still not very clear. In a first step, we aimed to investigate changes in the DC population of patients suffering [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-27T15:46:22+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/\",\"name\":\"Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2008-02-06T15:41:00+00:00\",\"dateModified\":\"2022-01-27T15:46:22+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/reduction-of-dendritic-cells-by-granulocyte-and-monocyte-adsorption-apheresis-in-patients-with-ulcerative-colitis\/","og_locale":"de_DE","og_type":"article","og_title":"Reduction of Dendritic Cells by Granulocyte and Monocyte Adsorption Apheresis in Patients with Ulcerative Colitis - Adacyte","og_description":"Grit Waitz\u00a01,\u00a0Sebastian Petermann,\u00a0Stefan Liebe,\u00a0Joerg Emmrich,\u00a0Wolfgang Ramlow Dig Dis Sci. 2008 Sep;53(9):2507-15.\u00a0doi: 10.1007\/s10620-007-0168-8.\u00a0Epub 2008 Feb 6. The influence of the granulocyte\/monocyte apheresis (GMCAP) on cell populations participating in mechanisms of tolerance, e.g. dendritic cells (DCs), is still not very clear. 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