{"id":6596,"date":"2020-12-01T17:05:00","date_gmt":"2020-12-01T17:05:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6596"},"modified":"2024-05-02T10:11:01","modified_gmt":"2024-05-02T08:11:01","slug":"refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/","title":{"rendered":"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis"},"content":{"rendered":"
\n

Masanao Nakamura<\/a> 1<\/a><\/sup>, Takeshi Yamamura<\/a> 1<\/a><\/sup>, Keiko Maeda<\/a> 2<\/a><\/sup>, Tsunaki Sawada<\/a> 2<\/a><\/sup>, Yasuyuki Mizutani<\/a> 1<\/a><\/sup>, Eri Ishikawa<\/a> 1<\/a><\/sup>, Ayako Ohashi<\/a> 1<\/a><\/sup>, Go Kajikawa<\/a> 1<\/a><\/sup>, Kazuhiro Furukawa<\/a> 1<\/a><\/sup>, Eizaburo Ohno<\/a> 1<\/a><\/sup>, Takashi Honda<\/a> 1<\/a><\/sup>, Hiroki Kawashima<\/a> 1<\/a><\/sup>, Masatoshi Ishigami<\/a> 1<\/a><\/sup>, Mitsuhiro Fujishiro<\/a> 1<\/a><\/sup><\/p>\n<\/div>\n\n

\n

Intern Med. 2020 Dec 1;59(23):3009-3014. doi: 10.2169\/internalmedicine.5302-20.\u00a0Epub 2020 Jul 28.<\/p>\n<\/div>\n\n

\n

Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no reports of the concomitant use of vedolizumab (VDZ) and GMA for the initial induction of UC. A 20-year-old man with refractory UC was admitted for recrudescence. VDZ monotherapy had previously been introduced but was ineffective. Therefore, he received scheduled combination of VDZ and GMA and achieved clinical remission. The combination of two different approaches to inhibit the migration of leukocytes into the inflamed tissue led to satisfactory clinical outcomes.<\/p>\n<\/div>\n\n

\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/32727993\/<\/a><\/p>\n<\/div>\n\n

\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7759717\/<\/a><\/p>\n<\/div>\n\n

\n

<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Masanao Nakamura 1, Takeshi Yamamura 1, Keiko Maeda 2, Tsunaki Sawada 2, Yasuyuki Mizutani 1, Eri Ishikawa 1, Ayako Ohashi 1, Go Kajikawa 1, Kazuhiro Furukawa 1, Eizaburo Ohno 1, Takashi Honda 1, Hiroki Kawashima 1, Masatoshi Ishigami 1, Mitsuhiro Fujishiro 1 Intern Med. 2020 Dec 1;59(23):3009-3014. doi: 10.2169\/internalmedicine.5302-20.\u00a0Epub 2020 Jul 28. Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no […]<\/p>\n","protected":false},"template":"","scientific_tags":[353,303,157,424,451,308,505,53,306,66],"class_list":["post-6596","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-biologic-refractory","scientific_tags-combination","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-induction","scientific_tags-mucosal-healing","scientific_tags-partial-response","scientific_tags-refractory-patients","scientific_tags-ulcerative-colitis","scientific_tags-vedolizumab"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32727993\/<\/a>\r\n\r\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7759717\/<\/a>"},"yoast_head":"\nRefractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Masanao Nakamura 1, Takeshi Yamamura 1, Keiko Maeda 2, Tsunaki Sawada 2, Yasuyuki Mizutani 1, Eri Ishikawa 1, Ayako Ohashi 1, Go Kajikawa 1, Kazuhiro Furukawa 1, Eizaburo Ohno 1, Takashi Honda 1, Hiroki Kawashima 1, Masatoshi Ishigami 1, Mitsuhiro Fujishiro 1 Intern Med. 2020 Dec 1;59(23):3009-3014. doi: 10.2169\/internalmedicine.5302-20.\u00a0Epub 2020 Jul 28. Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-02T08:11:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/\",\"name\":\"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2020-12-01T17:05:00+00:00\",\"dateModified\":\"2024-05-02T08:11:01+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/","og_locale":"de_DE","og_type":"article","og_title":"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte","og_description":"Masanao Nakamura 1, Takeshi Yamamura 1, Keiko Maeda 2, Tsunaki Sawada 2, Yasuyuki Mizutani 1, Eri Ishikawa 1, Ayako Ohashi 1, Go Kajikawa 1, Kazuhiro Furukawa 1, Eizaburo Ohno 1, Takashi Honda 1, Hiroki Kawashima 1, Masatoshi Ishigami 1, Mitsuhiro Fujishiro 1 Intern Med. 2020 Dec 1;59(23):3009-3014. doi: 10.2169\/internalmedicine.5302-20.\u00a0Epub 2020 Jul 28. Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no […]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/","og_site_name":"Adacyte","article_modified_time":"2024-05-02T08:11:01+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/","name":"Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2020-12-01T17:05:00+00:00","dateModified":"2024-05-02T08:11:01+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/refractory-ulcerative-colitis-improved-by-scheduled-combination-therapy-of-vedolizumab-and-granulocyte-and-monocyte-adsorptive-apheresis\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/6596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=6596"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=6596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}